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View Structure Prediction Details

Protein: hrs-1
Organism: Caenorhabditis elegans
Length: 521 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hrs-1.

Description E-value Query
Range
Subject
Range
hrs-1 - histidyl-tRNA synthetase (cytoplasmic) status:Confirmed UniProt:P34183 protein_id:CAA93416.1
337.0 [0..14] [521..14]

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Predicted Domain #1
Region A:
Residues: [1-60]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRTITSRLA FSVRQAEETV KPRIAYAQRS GRRIKEKVAL MQAKRKEAGE TGAPEKPGKF  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.09691
Match: 1wleA
Description: Crystal Structure of mammalian mitochondrial seryl-tRNA synthetase complexed with seryl-adenylate
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [61-521]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLKTGKGTRD YGPAQSALRN SVLQTVTETF NRYGAETIDT PVFELRDVLM GKYGEEGGKL  60
   61 VYDLQDQGGE LLSLRYDLTV PFARYLAMNK ITNITRYQIA KVYRRDQPVM SRGRYREFYQ 120
  121 CDFDIAGQYD LMLPEAECLG IVDELLTKLE IGEFFINLNH RLILEGMFAV SGIPAKDFKT 180
  181 ICSSVDKLDK TPWEDVEQEM INEKFLTKEQ TGKLGELVRF RELNSDLNNL ELLEKMSQLP 240
  241 DLGQNDKFKK GAEELKVLIE YLNVDGVTTV RYEPSLARGL DYYTGAIYEA VAPKALEGTA 300
  301 VENSEDTAGQ PVGVGSVAAG GRYDGLVKMF DSKANVPCCG VSFGIERLFA IMEARQKVAI 360
  361 RTTQTEVYVA SAQKNLVRDR KKLVKMLRSA GIKTEMALKA NPKLLTQFQY AEERRIPLAI 420
  421 VIGEQELKDG VVKLRNVVTR DEQTIKLDQL ITAVRDTLAA L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 81.69897
Match: 1httA
Description: Histidyl-tRNA synthetase (HisRS), C-terminal domain; Histidyl-tRNA synthetase (HisRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
ligase activity, forming aminoacyl-tRNA and related compounds 6.0520403280225 bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds 6.0520403280225 bayes_pls_golite062009
aminoacyl-tRNA ligase activity 6.04138870254626 bayes_pls_golite062009
histidine-tRNA ligase activity 5.91343220471745 bayes_pls_golite062009
ligase activity 4.85905957427768 bayes_pls_golite062009
proline-tRNA ligase activity 3.10945929267718 bayes_pls_golite062009
phenylalanine-tRNA ligase activity 2.99105702052936 bayes_pls_golite062009
serine-tRNA ligase activity 2.46505535069103 bayes_pls_golite062009
glycine-tRNA ligase activity 2.29229136935761 bayes_pls_golite062009
threonine-tRNA ligase activity 2.18642354927 bayes_pls_golite062009
alanine-tRNA ligase activity 1.82594054955281 bayes_pls_golite062009
lysine-tRNA ligase activity 1.72324031407565 bayes_pls_golite062009
binding 1.30923742450698 bayes_pls_golite062009
asparagine-tRNA ligase activity 0.921492123574877 bayes_pls_golite062009
catalytic activity 0.902495165806215 bayes_pls_golite062009
transcription regulator activity 0.375542987753806 bayes_pls_golite062009
protein binding 0.358563180490135 bayes_pls_golite062009
nucleic acid binding 0.281662799812287 bayes_pls_golite062009
DNA binding 0.0309732052586011 bayes_pls_golite062009
aspartate-tRNA ligase activity 0.00572514744734753 bayes_pls_golite062009

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