Protein Overview: pde-4

General Information:
Name(s) found:	pde-4 / CE33438 [WormBase]
Description(s) found: Found 20 descriptions. SHOW ALL	WBGene00020114 locus:pde-4 Probable 3',5'-cyclic phosphodiesterase pde-4 status:Confirmed UniProt:Q22000 protein_id:CCD69644.1 [WormBase]
Organism:	Caenorhabditis elegans
Length:	674 amino acids
Gene Ontology:
Cellular Component:	integral to membrane [IEA] synapse [IDA]
Biological Process:	signal transduction [IEA]
Molecular Function:	catalytic activity [IEA] 3',5'-cyclic-nucleotide phosphodiesterase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRRRGSSSS SSAAGGSGGG GGFGFSSLRR ELHLHNFFRT SSPSASSTSR TPPAALPPRT  60
   61 SAVTIPGSNH KLTSSASSYH PPRELTVSTF SAGSATAADG LGGAHLTPSL SSSVHARRES 120
  121 FLYRASDDLR EASSLRPVSR ASSIASNEHG HGDDLIVTPF AQLLASLRNV RSNLISITNI 180
  181 QNSDDSRHAN RSAKRPPLHN IELPDDVVHC AHDTLEELDW CLDQLETIQT HRSVSEMASS 240
  241 KFRKMLNKEL SHFAESSKSG TQVSKFLITT YMDKEEDEPS IEIEVPTEVQ GPSTSGPMTL 300
  301 SILKKAQTAA MNKISGVRKL RAPSHDGHVP EYGVNCAREI AVHMQRLDDW GPDVFKIDEL 360
  361 SKNHSLTVVT FSLLRQRNLF KTFEIHQSTL VTYLLNLEHH YRNNHYHNFI HAADVAQSMH 420
  421 VLLMSPVLTE VFTDLEVLAA IFAGAVHDVD HPGFTNQYLI NSNNELAIMY NDESVLEQHH 480
  481 LAVAFKLLQD SNCDFLANLS RKQRLQFRKI VIDMVLATDM SKHMSLLADL KTMVEAKKVA 540
  541 GNNVIVLDKY NDKIQVLQSM IHLADLSNPT KPIELYQQWN QRIMEEYWRQ GDKEKELGLE 600
  601 ISPMCDRGNV TIEKSQVGFI DYIVHPLYET WADLVYPDAQ NILDQLEENR EWYQSRIPEE 660
  661 PDTARTVTED DEHK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
cyclic-nucleotide phosphodiesterase activity	3.86434485322172	bayes_pls_golite062009
3',5'-cyclic-nucleotide phosphodiesterase activity	3.8566356686502	bayes_pls_golite062009
phosphoric diester hydrolase activity	3.16734214417311	bayes_pls_golite062009
3',5'-cyclic-AMP phosphodiesterase activity	2.29938697204184	bayes_pls_golite062009
3',5'-cyclic-GMP phosphodiesterase activity	2.29281173183086	bayes_pls_golite062009
catalytic activity	1.44092158711463	bayes_pls_golite062009
hydrolase activity	1.06080266556153	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.815214868148798	bayes_pls_golite062009
phosphoric ester hydrolase activity	0.196287846714023	bayes_pls_golite062009
binding	0.0840884387362641	bayes_pls_golite062009

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..201]	MSA	4.149994	View MSA. No confident structure predictions are available.
2	View Details	[202..296]	deduced	N/A	No confident structure predictions are available.
3	View Details	[297..674]	PSI-BLAST	127.0	Catalytic domain of cyclic nucleotide phosphodiesterase pde4d

Protein Overview: pde-4

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: