Protein Overview: lin-45

General Information:
Name(s) found:	lin-45 / CE31742 [WormBase]
Description(s) found: Found 15 descriptions. SHOW ALL	WBGene00003030 locus:lin-45 status:Partially_confirmed UniProt:Q07292 protein_id:CCD62344.1 [WormBase]
Organism:	Caenorhabditis elegans
Length:	614 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IEA]
Biological Process:	vulval development [IGI][IMP] nematode larval development [IGI][IMP] signal transduction [IEA] embryonic development ending in birth or egg hatching [IMP] Ras protein signal transduction [IGI] cell fate specification [IMP] protein amino acid phosphorylation [IEA] reproduction [IGI][IMP ]
Molecular Function:	ATP binding [IEA] protein tyrosine kinase activity [IEA] zinc ion binding [IEA] non-membrane spanning protein tyrosine kinase activity [IEA] protein kinase activity [IEA] receptor signaling protein activity [IEA] protein serine/threonine kinase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAMAVLYSV CHFHGGWNRR KSAPKSPVTS SQTPSSSSTR RRMSRINFKK SSASTTPTSP  60
   61 HCPSPRLISL PRCASSSIDR KDQASPMASP STPLYPKHSD SLHSLSGHHS AGGAGTSDKE 120
  121 PPKFKYKMIM VHLPFDQHSR VEVRPGETAR DAISKLLKKR NITPQLCHVN ASSDPKQESI 180
  181 ELSLTMEEIA SRLPGNELWV HSEYLNTVSS IKHAIVRRTF IPPKSCDVCN NPIWMMGFRC 240
  241 EFCQFKFHQR CSSFAPLYCD LLQSVPKNED LVKELFGIAS QVEGPDRSVA EIVLANLAPT 300
  301 SGQSPAATPD SSHPDLTSIK RTGGVKRHPM AVSPQNETSQ LSPSGPYPRD RSSSAPNINA 360
  361 INDEATVQHN QRILDALEAQ RLEEESRDKT GSLLSTQARH RPHFQSGHIL SGARMNRLHP 420
  421 LVDCTPLGSN SPSSTCSSPP GGLIGQPTLG QSPNVSGSTT SSLVAAHLHT LPLTPPQSAP 480
  481 PQKISPGFFR NRSRSPGERL DAQRPRPPQK PHHEDWEILP NEFIIQYKVG SGSFGTVYRG 540
  541 EFFGTVAIKK LNVVDPTPSQ MAAFKNEVAV LKKTRHLNVL LFMGWVREPE IAIITQWCEG 600
  601 SSLYRHIHVQ GDLN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

No microscopy data found in the PDR for this protein.

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..90]	deduced	N/A	No confident structure predictions are available.
2	View Details	[91..184]	PSI-BLAST	16.69897	THE RAS-BINDING DOMAIN OF RAF-1 FROM RAT, NMR, 1 STRUCTURE
3	View Details	[185..285]	PSI-BLAST	9.045757	Crystal Structure of the Human Beta2-Chimaerin
4	View Details	[286..477]	deduced	N/A	No confident structure predictions are available.
5	View Details	[478..614]	PSI-BLAST	22.69897	No description for 2fb8A was found.

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

Term	Confidence	Notes
binding	2.35732272412639	bayes_pls_golite062009
protein binding	1.86841453215444	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.63853240069891	bayes_pls_golite062009
kinase activity	1.62384132584197	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.51475136357956	bayes_pls_golite062009
transferase activity	1.25776281736571	bayes_pls_golite062009
protein kinase activity	1.13077363367159	bayes_pls_golite062009
protein serine/threonine kinase activity	0.673589832597734	bayes_pls_golite062009
GTPase regulator activity	0.334601927012824	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	0.315664702789604	bayes_pls_golite062009
enzyme regulator activity	0.162163146322721	bayes_pls_golite062009
protein tag	0.00311613478935058	bayes_pls_golite062009

3

Term	Confidence	Notes
binding	2.36195429973813	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.10625597744594	bayes_pls_golite062009
kinase activity	2.03632850156074	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.8531437045627	bayes_pls_golite062009
transferase activity	1.4550521488922	bayes_pls_golite062009
GTPase regulator activity	1.39167263636091	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	1.37139209958305	bayes_pls_golite062009
protein kinase activity	1.34251805835141	bayes_pls_golite062009
protein binding	1.29100556128076	bayes_pls_golite062009
protein serine/threonine kinase activity	0.956859696337723	bayes_pls_golite062009
enzyme regulator activity	0.911061212692491	bayes_pls_golite062009
guanyl-nucleotide exchange factor activity	0.907368864863833	bayes_pls_golite062009
small GTPase regulator activity	0.661240850692236	bayes_pls_golite062009
transcription regulator activity	0.487499907025216	bayes_pls_golite062009
catalytic activity	0.194464246602439	bayes_pls_golite062009
nucleic acid binding	0.0210137897362572	bayes_pls_golite062009

4

No functions predicted.

5

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.96

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle