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Protein Overview: wwp-1

General Information:
Name(s) found: wwp-1 / CE31384 [WormBase]
Description(s) found:
Found 17 descriptions.
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  • WBGene00007009 locus:wwp-1 E3 ubiquitin-protein ligase status:Confirmed UniProt:Q9N2Z7 protein_id:CCD71931.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 794 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEALink to PubMed article]
    Biological Process: embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    protein modification process [IEALink to PubMed article]
    ubiquitin cycle [IEALink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IEALink to PubMed article]
    protein binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MARNEPSSQQ PSSSGSNGTP AQQNGSAKPS KVTVKVVNAS FTKAADCYVE ITSDTSSAAP  60
   61 KKTTVKKKTM APEWNEHLNV HANESSTISF RLLQKAKLFD DTCLGMAKLK LSSLTRNENG 120
  121 EFKNDINNIS LLAKDSSKIG TLNIIFSGYP ERKRRSAGVR AETAASASSE ASTSNGVATS 180
  181 SSARRPATAK RDTLAAPTST AAAAAAATAG GTPAAGAEEQ LPDGWEMRFD QYGRKYYVDH 240
  241 TTKSTTWERP STQPLPQGWE MRRDPRGRVY YVDHNTRTTT WQRPTADMLE AHEQWQSGRD 300
  301 QAMLQWEQRF LLQQNNFSAD DPLGPLPEGW EKRQDPNTSR MYFVNHVNRT TQWEDPRTQG 360
  361 FRGSDQPLPD GWEMRFTEQG VPFFIDHQSK TTTYNDPRTG KPVGPLGVVG VQMAMEKSFR 420
  421 WKIAQFRYLC LSNSVPNHVK ITVSRNNVFE DSFQEIMRKN AVDLRRRLYI QFRGEEGLDY 480
  481 GGVAREWFFL LSHEVLNPMY CLFMYAGNNN YSLQINPASF VNPDHLKYFE YIGRFIAMAL 540
  541 FHGKFIYSGF TMPFYKKMLN KKIVLKDIEQ VDSEIYNSLM WIKDNNIDEC DMELYFVADY 600
  601 ELLGELKTYE LKEGGTEIAV TEENKLEYIE LLVEWRFNRG VEQQTKAFFT GFNSVFPLEW 660
  661 MQYFDERELE LLLCGMQDVD VDDWQRNTVY RHYAPQSKQV TWFWQWVRSL DQEKRARLLQ 720
  721 FVTGTCRVPV GGFSELMGST GPQLFCIERV GKENWLPRSH TCFNRLDLPP YRSYDQLVEK 780
  781 LSMAIEMTEG FGNE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..218] PSI-BLAST 24.39794 Synaptogamin I
    2 View Details [219..399] FFAS03 3.32 NMR structure of WW domains (WW3-4) from Suppressor of Deltex
    3 View Details [400..794] PSI-BLAST 119.0 Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT domain E3 Ligase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  3.13196227814032 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  2.50663692075518 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.38996385458463 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  2.33627990300135 bayes_pls_golite062009
  • transcription activator activity
    		•  1.7271283334564 bayes_pls_golite062009
  • transcription factor binding
    		•  1.70374758907671 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  1.67021314973391 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  1.64250861692227 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.5022756775252 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.33590567799099 bayes_pls_golite062009
  • protein binding
    		•  1.27041711914941 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  0.9455445085372 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  0.863094487787088 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  0.863094487787088 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  0.863094487787088 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.539489048525578 bayes_pls_golite062009
  • catalytic activity
    		•  0.231344568578849 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.179456065780754 bayes_pls_golite062009
    3
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  7.14616396317218 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  6.99796579811325 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  6.03005793772151 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  4.50502148129705 bayes_pls_golite062009
  • sodium channel inhibitor activity
    		•  3.64966529121446 bayes_pls_golite062009
  • binding
    		•  3.09019421479054 bayes_pls_golite062009
  • ion channel inhibitor activity
    		•  2.14402963004533 bayes_pls_golite062009
  • channel inhibitor activity
    		•  2.14402963004533 bayes_pls_golite062009
  • ligase activity
    		•  1.85936914071714 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.53041428769512 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.45373137371678 bayes_pls_golite062009
  • DNA binding
    		•  1.32990029553036 bayes_pls_golite062009
  • protein binding
    		•  1.29390544644063 bayes_pls_golite062009
  • sodium channel regulator activity
    		•  1.19047973745862 bayes_pls_golite062009
  • catalytic activity
    		•  1.15152367676155 bayes_pls_golite062009
  • transcription factor binding
    		•  0.558655949211634 bayes_pls_golite062009
  • ubiquitin-ubiquitin ligase activity
    		•  0.373649200425601 bayes_pls_golite062009
  • channel regulator activity
    		•  0.072778668515899 bayes_pls_golite062009
    		• 0.051942165438844 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle