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Protein Overview: mek-1

General Information:
Name(s) found: mek-1 / CE30816 [WormBase]
Description(s) found:
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  • WBGene00003185 locus:mek-1 status:Confirmed UniProt:Q21307 protein_id:CCD62387.1 [WormBase]
  • gi|71993310|ref|NP_001024771.1| MAP kinase kinase or Erk Kinase family member (mek-1) [Caenorhabditis elegans] [NCBI NR]
  • ref|NP_509263.2| MAP kinase kinase or Erk Kinase (39.4 kD) (mek-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|21106013|gb|AAA79746.2| Map kinase kinase or erk kinase protein 1, isoform a [Caenorhabditis elegans] [NCBI NR]
  • Dual specificity mitogen-activated protein kinase kinase mek-1 OS=Caenorhabditis elegans GN=mek-1 PE=1 SV=2 [Swiss-Prot]
  • [wormpep88.fasta]
  • CE30816 WBGene00003185 locus:mek-1 Map kinase kinase status:Confirmed TR:Q21307 protein_id:AAA79746.2 [wormpep150.fasta]
  • 30816 WBGene00003185 locus:mek-1 Map kinase kinase status:Confirmed TR:Q21307 protein_id:AAA79746.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • MAP kinase kinase or Erk Kinase (39.4 kD) (mek-1) [Caenorhabditis elegans]gi|21106013|gb|AAA79746.2| Map kinase kinase or erk kinase protein 1, isoform a [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • locus:mek-1 Map kinase kinase status:Confirmed TR:Q21307 protein_id:AAA79746.2 [wormpep115.fasta.reversed]
  • CE30816 locus:mek-1 Map kinase kinase status:Confirmed [wormpep80.hongbin]
  • CE30816 WBGene00003185 locus:mek-1 Map kinase kinase status:Confirmed UniProt:Q21307_CAEEL protein_id:AAA79746.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE30816 WBGene00003185 locus:mek-1 Map kinase kinase status:Confirmed UniProt:Q21307_CAEEL protein_id:AAA79746.2| [wormORF-contam.fasta]
  • Map kinase kinase or erk kinase protein 1, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • MAP kinase kinase or Erk Kinase family member (mek-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE30816 WBGene00003185 locus:mek-1 Map kinase kinase status:Confirmed UniProt:Q21307 protein_id:AAA79746.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE30816 WBGene00003185 locus:mek-1 Map kinase kinase status:Confirmed UniProt:Q21307 protein_id:CCD62387.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE30816 WBGene00003185 locus:mek-1 status:Confirmed UniProt:Q21307 protein_id:CCD62387.1 [wormpep246-ecoli-contam.fasta]
  • CE30816 WBGene00003185 locus:mek-1 status:Confirmed UniProt:Q21307 protein_id:CCD62387.1 Dual specificity mitogen-activated protein kinase kinase mek-1 [c_elegans-PRJNA13758-WS250-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 347 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ICLink to PubMed article]
    Biological Process: response to temperature stimulus [IMPLink to PubMed article]
    female meiosis [IMPLink to PubMed article]
    male meiosis [IMPLink to PubMed article]
    response to copper ion [IMPLink to PubMed articleLink to PubMed article]
    response to starvation [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    activation of JUN kinase activity [IDALink to PubMed article]
    response to cadmium ion [IMPLink to PubMed articleLink to PubMed article]
    oocyte differentiation [IMPLink to PubMed article]
    regulation of growth rate [IGILink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    MAPKKK cascade [IDALink to PubMed article][IMPLink to PubMed article]
    activation of MAPK activity [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    serine-type endopeptidase inhibitor activity [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    MAP kinase kinase activity [IDALink to PubMed article][IMPLink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]
    JUN kinase kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERDFDLGMG RPGGLGGLGG EPIMQQMPQP APHHPSRSSN DHNVKNLMKQ AEENSGYLTL  60
   61 QGNRRKADLK ELQFVEDIGH GSCGTVTKCR YKSVIMAVKT MPRTSNSYEM SRILMDLDVI 120
  121 CLSFDCPYIV RCFGYFITNF DVRVCMECMA TCLDRLLIRI KQPIPERIIG KLSVSIIKAL 180
  181 HYLKTKHQIM HRDVKPSNIL LDWSGVIKLC DFGIAGRLIE SRAHSKQAGC PLYMGPERLD 240
  241 PNNFDSYDIR SDVWSFGVTL VELATGQYPY AGTEFDMMSK ILNDEPPRLD PAKFSPDFCQ 300
  301 LVESCLQRDP TMRPNYDMLL QHPFVVHHEK IETDVEEWFA DVMGECG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..347] PSI-BLAST 52.522879 No description for 2dylA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle