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Protein Overview: mtm-1

General Information:
Name(s) found: mtm-1 / CE30707 [WormBase]
Description(s) found:
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  • WBGene00003475 locus:mtm-1 status:Partially_confirmed UniProt:Q9N589 protein_id:CCD66194.1 [WormBase]
  • gi|25144028|ref|NP_491531.2| MTM (myotubularin) family member (mtm-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|20451267|gb|AAF60423.3| Mtm (myotubularin) family protein 1 [Caenorhabditis elegans] [NCBI NR]
  • Myotubularin-related protein 1 OS=Caenorhabditis elegans GN=mtm-1 PE=1 SV=2 [Swiss-Prot]
  • [wormpep79.fasta]
  • CE30707 WBGene00003475 locus:mtm-1 myotubularin-like protein status:Partially_confirmed TR:Q9N589 protein_id:AAF60423.3 [wormpep150.fasta]
  • 30707 WBGene00003475 locus:mtm-1 myotubularin-like protein status:Partially_confirmed TR:Q9N589 protein_id:AAF60423.3 [wormpep130-phg-ecoli-orf-rand.fasta]
  • myotubularin (1F705) [Caenorhabditis elegans]gi|20451267|gb|AAF60423.3| Mtm (myotubularin) family protein 1 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • locus:mtm-1 myotubularin-like protein status:Partially_confirmed TR:Q9N589 protein_id:AAF60423.3 [wormpep115.fasta.reversed]
  • CE30707 myotubularin-like protein status:Partially_confirmed TR:Q9N589 protein_id:AAF60423.3 [wormpep80.hongbin]
  • CE30707 WBGene00003475 locus:mtm-1 myotubularin-like protein status:Partially_confirmed UniProt:Q9N589_CAEEL protein_id:AAF60423.3 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE30707 WBGene00003475 locus:mtm-1 myotubularin-like protein status:Partially_confirmed UniProt:Q9N589_CAEEL protein_id:AAF60423.3| [wormORF-contam.fasta]
  • MTM (myotubularin) family member (mtm-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Mtm (myotubularin) family protein 1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE30707 WBGene00003475 locus:mtm-1 myotubularin-like protein status:Partially_confirmed UniProt:Q9N589 protein_id:AAF60423.3 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE30707 WBGene00003475 locus:mtm-1 myotubularin-like protein status:Partially_confirmed UniProt:Q9N589 protein_id:CCD66194.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE30707 WBGene00003475 locus:mtm-1 status:Partially_confirmed UniProt:Q9N589 protein_id:CCD66194.1 [wormpep246-ecoli-contam.fasta]
  • MTM (Myotubularin) family OS=Caenorhabditis elegans GN=mtm-1 PE=1 SV=2 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 588 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDA]
    Biological Process: phospholipid dephosphorylation [IEALink to PubMed article]
    protein amino acid dephosphorylation [IEALink to PubMed article]
    dephosphorylation [IEALink to PubMed article]
    Molecular Function: inositol or phosphatidylinositol phosphatase activity [IEALink to PubMed article]
    protein tyrosine phosphatase activity [IEALink to PubMed article]
    phosphatase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDRGNNSGE VGEFASSSMI QESIDLKLLA AESLIWTEKN VTYFGPLGKF PGKIVITRYR  60
   61 MVFLVGDGGK MYEQWKLDIP LGQVSRIEKV GRKTTSVAKR GDDNYGFTIY CKDYRVYRFT 120
  121 CNPASSDRKN VCDSLNRYAF PLSHNLPMFA SVHAAETPRL MKDGWKIYSA EKEYERLGIP 180
  181 NSRLWKEVDI NKDYKFSETY PRTFVIPTVS WEEGKPFVKK LGEFRSKERI PVLSWINQTT 240
  241 LASISRCSQP MTGISGKRSA EDERHLTNIM NANANCRELL ILDARPAVNA KLNKAKGGGY 300
  301 EENYVNAPLT FLNIHNIHVV RDSLKRLLAA LIPRVDEKGY YKALDESKWL NHVQSILEGA 360
  361 VKAVFNVDTE KQSVLIHCSD GWDRTAQLTS LAMIQLDSYY RTIEGFIVLI EKEWCSFGHK 420
  421 FGERIGHGDD NYSDGERSPV FVQFCDCLWQ IMRQFPWAFE FTQELLICML DELYACRYGT 480
  481 FLYNSEKIRL KDKKCDETTI SFWSYVLENK KKFRNPMFKH GKSNKVINVN PSLCGLHVWI 540
  541 DYYARSNPYV VTPNHEDVQQ PGAQFVDEKK QLLDEIMALD DAAQKLTA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..588] PSI-BLAST 1000.0 Crystal Structure of Myotubularin-related protein 2 complexed with phosphate

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.30669036331612 bayes_pls_golite062009
  • phosphatase activity
    		•  7.03758345564381 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.82821455971597 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  6.07449851643404 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.83769298632658 bayes_pls_golite062009
  • transmembrane receptor protein phosphatase activity
    		•  4.57221148210263 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine phosphatase activity
    		•  4.57221148210263 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  4.03975183132282 bayes_pls_golite062009
  • protein tyrosine/serine/threonine phosphatase activity
    		•  2.77531895423367 bayes_pls_golite062009
  • phosphatidylinositol-3-phosphatase activity
    		•  2.60529675907066 bayes_pls_golite062009
  • phosphatidylinositol trisphosphate phosphatase activity
    		•  2.05577133553311 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.9728915436342 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  1.95004535887255 bayes_pls_golite062009
  • signal transducer activity
    		•  1.82459113680471 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.82459113680471 bayes_pls_golite062009
  • receptor activity
    		•  1.80988489233673 bayes_pls_golite062009
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
    		•  1.72084618199574 bayes_pls_golite062009
  • hydrolase activity
    		•  1.69828702692962 bayes_pls_golite062009
  • phosphatidylinositol bisphosphate phosphatase activity
    		•  1.51576958903553 bayes_pls_golite062009
  • binding
    		•  1.42026750513729 bayes_pls_golite062009
  • transporter activity
    		•  1.21792561830727 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  1.1200449509328 bayes_pls_golite062009
  • protein binding
    		•  1.07441758584517 bayes_pls_golite062009
  • catalytic activity
    		•  1.06283028154109 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.00030784939308 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine phosphatase activity
    		•  0.724257798127697 bayes_pls_golite062009
  • receptor binding
    		•  0.576374232132305 bayes_pls_golite062009
  • kinase activity
    		•  0.541255358115631 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.532875179381704 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.48365008254428 bayes_pls_golite062009
  • protein kinase activity
    		•  0.44918511259618 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.359793029026564 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.355387992614734 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.335498703113274 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.24539676571154 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase signaling protein activity
    		•  0.13700176999256 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle