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Protein Overview: eri-1

General Information:
Name(s) found: eri-1 / CE30163 [WormBase]
Description(s) found:
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  • WBGene00001332 locus:eri-1 3'-5' exonuclease eri-1 status:Partially_confirmed UniProt:O44406 protein_id:CCD73976.1 [WormBase]
  • gi|45476772|sp|O44406.2|ERI1_CAEEL RecName: Full=3'-5' exonuclease eri-1; AltName: Full=Enhanced RNAi protein [NCBI NR]
  • gi|25148199|ref|NP_741292.1| Enhanced RNAI (RNA interference) family member (eri-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|18030164|gb|AAK39277.2| Enhanced rnai (rna interference) protein 1, isoform b [Caenorhabditis elegans] [NCBI NR]
  • 3'-5' exonuclease eri-1 OS=Caenorhabditis elegans GN=eri-1 PE=1 SV=2 [Swiss-Prot]
  • [wormpep79.fasta]
  • CE30163 WBGene00001332 locus:eri-1 status:Partially_confirmed SW:O44406 protein_id:AAK39277.2 [wormpep150.fasta]
  • 30163 WBGene00001332 locus:eri-1 status:Partially_confirmed SW:O44406 protein_id:AAK39277.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • prion protein interacting 1 like (67.2 kD) (4B170) [Caenorhabditis elegans]gi|18030164|gb|AAK39277.2| Enhanced rnai (rna interference) protein 1, isoform b [Caenorhabditis elegans]gi|45476772|sp|O44406|ERI1_CAEEL 3'-5' exonuclease eri-1 (Enhanced RNAi p [nrdb_11152004_Chlamydomonas]
  • status:Partially_confirmed TR:O44407 protein_id:AAK39277.2 [wormpep115.fasta.reversed]
  • CE30163 status:Partially_confirmed TR:O44407 protein_id:AAK39277.2 [wormpep80.hongbin]
  • CE30163 WBGene00001332 locus:eri-1 status:Partially_confirmed UniProt:O44406 protein_id:AAK39277.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE30163 WBGene00001332 locus:eri-1 status:Partially_confirmed UniProt:O44406 protein_id:AAK39277.2| [wormORF-contam.fasta]
  • 3'-5' exonuclease eri-1 (Enhanced RNAi protein) [nr-271106-contam.fasta]
  • Enhanced RNAI (RNA interference) family member (eri-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Enhanced rnai (rna interference) protein 1, isoform b [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE30163 WBGene00001332 locus:eri-1 status:Partially_confirmed UniProt:O44406 protein_id:CCD73976.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE30163 WBGene00001332 locus:eri-1 status:Partially_confirmed UniProt:O44406 protein_id:CCD73976.1 3'-5' exonuclease eri-1 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 582 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    intracellular [IEALink to PubMed article]
    Biological Process: reproductive process in a multicellular organism [IMPLink to PubMed article]
    meiotic chromosome segregation [IMPLink to PubMed article]
    RNA interference [IMPLink to PubMed article]
    RNA catabolic process [IDALink to PubMed article]
    Molecular Function: nucleic acid binding [IEALink to PubMed article][ISSLink to PubMed article]
    3'-5'-exoribonuclease activity [IDALink to PubMed article]
    exonuclease activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSADEPSPED EKYLESLRDL LKISQEFDAS NAKQNDEPEK TAVEVESAET RTDESEKSID  60
   61 IPREQQLLPS ERVEPLKSMV EPEYVKKVIR QMDTMTAEQL KQALMKIKVS TGGNKKTLRK 120
  121 RVAQYYRKEN ALLNRKMEPN ADKTARFFDY LIAIDFECTC VEIIYDYPHE IIELPAVLID 180
  181 VREMKIISEF RTYVRPVRNP KLSEFCMQFT KIAQETVDAA PYFREALQRL YTWMRKFNLG 240
  241 QKNSRFAFVT DGPHDMWKFM QFQCLLSNIR MPHMFRSFIN IKKTFKEKFN GLIKGNGKSG 300
  301 IENMLERLDL SFVGNKHSGL DDATNIAAIA IQMMKLKIEL RINQKCSYKE NQRSAARKDE 360
  361 ERELEDAANV DLTSVDISRR DFQLWMRRLP LKLSSVTRRE FINEEYLDCD SCDDLTDDKN 420
  421 DEAAFQEKMA IREYLENKQT EDFAKIAAER GIFKIGEIKS YQTARPIIED DDVDVESEEE 480
  481 DYGTEFEMLE VVERMPPVSS TLHTEVDLDA VWERDGGSDS ERENLSNAPS LHEFPSSSTS 540
  541 SPHATSEHVT SSSPLHIDDD VDRVLNAPPK NSLASSSNRS SF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..147] PSI-BLAST 43.221849 No description for 1zbuA was found.
    2 View Details [148..495] PSI-BLAST 23.0 Exonuclease I
    3 View Details [496..582] PSI-BLAST 34.09691 No description for 2hnhA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • hydrolase activity, acting on ester bonds
    		•  2.70794511869438 bayes_pls_golite062009
  • hydrolase activity
    		•  2.41899414621161 bayes_pls_golite062009
  • exonuclease activity
    		•  2.2254764376369 bayes_pls_golite062009
  • nuclease activity
    		•  2.17358374135419 bayes_pls_golite062009
  • endonuclease activity
    		•  2.16624569270454 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.46350199863273 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.27214452726777 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.19309748194103 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.16832482049746 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.1219517187744 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.03744130737493 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.989567747245467 bayes_pls_golite062009
  • DNA binding
    		•  0.905114452869468 bayes_pls_golite062009
  • ribonuclease H activity
    		•  0.869940880547909 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.830848153280868 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.717600245625866 bayes_pls_golite062009
  • binding
    		•  0.715089866064182 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.686787036410342 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.681014317532767 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  0.568273228950698 bayes_pls_golite062009
    		• 0.29136121058876 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.278838342302102 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.261428436029202 bayes_pls_golite062009
  • RNA binding
    		•  0.239100354404122 bayes_pls_golite062009
  • double-stranded RNA-specific ribonuclease activity
    		•  0.222737597484808 bayes_pls_golite062009
  • transcription factor activity
    		•  0.2075295274818 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.115254148049348 bayes_pls_golite062009
  • protein binding
    		•  0.035326007863533 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.016619833072142 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle