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View Structure Prediction Details

Protein: eri-1
Organism: Caenorhabditis elegans
Length: 582 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for eri-1.

Description E-value Query
Range		 Subject
Range
gi|152976184, gi... - gi|89203212|ref|ZP_01181903.1| DNA polymerase III, epsilon subunit:DNA polymerase III, alpha subunit...
 406.0 [0..2] [581..273]

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Predicted Domain #1
Region A:
Residues: [1-147] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSADEPSPED EKYLESLRDL LKISQEFDAS NAKQNDEPEK TAVEVESAET RTDESEKSID  60
   61 IPREQQLLPS ERVEPLKSMV EPEYVKKVIR QMDTMTAEQL KQALMKIKVS TGGNKKTLRK 120
  121 RVAQYYRKEN ALLNRKMEPN ADKTARF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 43.221849
Match: 1zbuA
Description: No description for 1zbuA was found.

Predicted Domain #2
Region A:
Residues: [148-495] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FDYLIAIDFE CTCVEIIYDY PHEIIELPAV LIDVREMKII SEFRTYVRPV RNPKLSEFCM  60
   61 QFTKIAQETV DAAPYFREAL QRLYTWMRKF NLGQKNSRFA FVTDGPHDMW KFMQFQCLLS 120
  121 NIRMPHMFRS FINIKKTFKE KFNGLIKGNG KSGIENMLER LDLSFVGNKH SGLDDATNIA 180
  181 AIAIQMMKLK IELRINQKCS YKENQRSAAR KDEERELEDA ANVDLTSVDI SRRDFQLWMR 240
  241 RLPLKLSSVT RREFINEEYL DCDSCDDLTD DKNDEAAFQE KMAIREYLEN KQTEDFAKIA 300
  301 AERGIFKIGE IKSYQTARPI IEDDDVDVES EEEDYGTEFE MLEVVERM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.0
Match: 1fxxA
Description: Exonuclease I
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity, acting on ester bonds 2.70794511869438 bayes_pls_golite062009
hydrolase activity 2.41899414621161 bayes_pls_golite062009
exonuclease activity 2.2254764376369 bayes_pls_golite062009
nuclease activity 2.17358374135419 bayes_pls_golite062009
endonuclease activity 2.16624569270454 bayes_pls_golite062009
ribonuclease activity 1.46350199863273 bayes_pls_golite062009
nucleic acid binding 1.27214452726777 bayes_pls_golite062009
catalytic activity 1.25233849524628 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 1.19309748194103 bayes_pls_golite062009
transcription regulator activity 1.16832482049746 bayes_pls_golite062009
deoxyribonuclease activity 1.1219517187744 bayes_pls_golite062009
exoribonuclease activity 1.03744130737493 bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters 0.989567747245467 bayes_pls_golite062009
DNA binding 0.905114452869468 bayes_pls_golite062009
ribonuclease H activity 0.869940880547909 bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters 0.830848153280868 bayes_pls_golite062009
DNA polymerase activity 0.717600245625866 bayes_pls_golite062009
binding 0.715089866064182 bayes_pls_golite062009
3'-5'-exoribonuclease activity 0.686787036410342 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.681014317532767 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.568273228950698 bayes_pls_golite062009
0.29136121058876 bayes_pls_golite062009
exodeoxyribonuclease activity 0.278838342302102 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.261428436029202 bayes_pls_golite062009
RNA binding 0.239100354404122 bayes_pls_golite062009
double-stranded RNA-specific ribonuclease activity 0.222737597484808 bayes_pls_golite062009
transcription factor activity 0.2075295274818 bayes_pls_golite062009
3'-5' exonuclease activity 0.115254148049348 bayes_pls_golite062009
protein binding 0.035326007863533 bayes_pls_golite062009
endoribonuclease activity 0.016619833072142 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [496-582] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPVSSTLHTE VDLDAVWERD GGSDSERENL SNAPSLHEFP SSSTSSPHAT SEHVTSSSPL  60
   61 HIDDDVDRVL NAPPKNSLAS SSNRSSF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.09691
Match: 2hnhA
Description: No description for 2hnhA was found.
YRC Informatics Platform - Version 3.0
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