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Protein Overview: cep-1

General Information:
Name(s) found: cep-1 / CE29805 [WormBase]
Description(s) found:
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  • WBGene00000467 locus:cep-1 Transcription factor cep-1 status:Confirmed UniProt:Q20646 protein_id:CAA99857.2 [WormBase]
  • gi|74964744|sp|Q20646.2|CEP1_CAEEL RecName: Full=Transcription factor cep-1; AltName: Full=C.elegans p53-like protein 1 [NCBI NR]
  • gi|71986660|ref|NP_001021478.1| P-53-like protein family member (cep-1) [Caenorhabditis elegans] [NCBI NR]
  • ref|NP_492262.2| C.Elegans p53 tumor suppressor-like transcription factor, necessary for DNA damage induced germline apoptosis (74.6 kD) (cep-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|18376520|emb|CAA99857.2| C. elegans protein F52B5.5a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|16755902|gb|AAL28139.1|AF440800_1 transcription factor CEP-1 [Caenorhabditis elegans] [NCBI NR]
  • Transcription factor cep-1 OS=Caenorhabditis elegans GN=cep-1 PE=1 SV=2 [Swiss-Prot]
  • [wormpep79.fasta]
  • CE29805 WBGene00000467 locus:cep-1 status:Confirmed TR:Q20646 protein_id:CAA99857.2 [wormpep150.fasta]
  • 29805 WBGene00000467 locus:cep-1 status:Confirmed TR:Q20646 protein_id:CAA99857.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • C.Elegans p53 tumor suppressor-like transcription factor, necessary for DNA damage induced germline apoptosis (74.6 kD) (cep-1) [Caenorhabditis elegans]gi|16755902|gb|AAL28139.1| transcription factor CEP-1 [Caenorhabditis elegans]gi|18376520|emb|CAA9985 [nrdb_11152004_Chlamydomonas]
  • locus:cep-1 status:Confirmed TR:Q20646 protein_id:CAA99857.2 [wormpep115.fasta.reversed]
  • CE29805 locus:cep-1 status:Confirmed TR:Q20646 protein_id:CAA99857.2 [wormpep80.hongbin]
  • CE29805 WBGene00000467 locus:cep-1 status:Confirmed UniProt:Q20646_CAEEL protein_id:CAA99857.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE29805 WBGene00000467 locus:cep-1 status:Confirmed UniProt:Q20646_CAEEL protein_id:CAA99857.2| [wormORF-contam.fasta]
  • transcription factor CEP-1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • C.Elegans P-53-like protein family member (cep-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein F52B5.5a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE29805 WBGene00000467 locus:cep-1 status:Confirmed UniProt:Q20646 protein_id:CAA99857.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE29805 WBGene00000467 locus:cep-1 status:Confirmed UniProt:Q20646 protein_id:CAA99857.2 Transcription factor cep-1 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 644 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    nucleoplasm [IDALink to PubMed article]
    Biological Process: embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    meiotic chromosome segregation [IMPLink to PubMed article]
    DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis [IGILink to PubMed article][IMPLink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    regulation of transcription [IDALink to PubMed article]
    response to stress [IMPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    transcription factor activity [IDALink to PubMed article]
    zinc ion binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPDDSQLSD ILKDARIPDS QDIGVNLTQN LSFDTVQKMI DGVFTPIFSQ GTEDSLEKDI  60
   61 LKTPGISTIY NGILGNGEET KKRTPKISDA FEPDLNTSGD VFDSDKSEDG LMNDESYLSN 120
  121 TTLSQVVLDS QKYEYLRVRT EEEQQLVIEK RARERFIRKS MKIAEETALS YENDGSRELS 180
  181 ETMTQKVTQM DFTETNVPFD GNDESSNLAV RVQSDMNLNE DCEKWMEIDV LKQKVAKSSD 240
  241 MAFAISSEHE KYLWTKMGCL VPIQVKWKLD KRHFNSNLSL RIRFVKYDKK ENVEYAIRNP 300
  301 RSDVMKCRSH TEREQHFPFD SFFYIRNSEH EFSYSAEKGS TFTLIMYPGA VQANFDIIFM 360
  361 CQEKCLDLDD RRKTMCLAVF LDDENGNEIL HAYIKQVRIV AYPRRDWKNF CEREDAKQKD 420
  421 FRFPELPAYK KASLESINIK QEVNLENMFN VTNTTAQMEP STSYSSPSNS NNRKRFLNEC 480
  481 DSPNNDYTMM HRTPPVTGYA SRLHGCVPPI ETEHENCQSP SMKRSRCTNY SFRTLTLSTA 540
  541 EYTKVVEFLA REAKVPRYTW VPTQVVSHIL PTEGLERFLT AIKAGHDSVL FNANGIYTMG 600
  601 DMIREFEKHN DIFERIGIDS SKLSKYYEAF LSFYRIQEAM KLPK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..216] deduced N/A No confident structure predictions are available.
    2 View Details [217..432] PSI-BLAST 111.0 Structural Differences in the DNA Binding Domains of Human p53 and its C. elegans Ortholog Cep-1: Structure of C. elegans Cep-1
    3 View Details [433..644] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.48951024516114 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.08461887975954 bayes_pls_golite062009
  • DNA binding
    		•  2.00590712396281 bayes_pls_golite062009
  • protein binding
    		•  1.89777739609026 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.81190570165535 bayes_pls_golite062009
  • transcription factor activity
    		•  1.47792643319772 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.83908184260106 bayes_pls_golite062009
  • transcription activator activity
    		•  0.70688258731336 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.67114633230283 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.60405934196774 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  0.59003565500643 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.41353824553911 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle