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Protein Overview: pef-1

General Information:
Name(s) found: pef-1 / CE30662 [WormBase]
Description(s) found:
Found 17 descriptions.
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  • WBGene00003969 locus:pef-1 Serine\/threonine-protein phosphatase status:Confirmed UniProt:Q8MYR2 protein_id:CCD69950.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 572 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    cytoplasm [IEALink to PubMed article]
    neuronal cell body [IDALink to PubMed article]
    Biological Process: detection of stimulus involved in sensory perception [IEALink to PubMed article]
    protein amino acid dephosphorylation [IEALink to PubMed article]
    Molecular Function: phosphoprotein phosphatase activity [IEALink to PubMed article]
    bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity [IEALink to PubMed article]
    iron ion binding [IEALink to PubMed article]
    calcium ion binding [IEALink to PubMed article]
    manganese ion binding [IEALink to PubMed article]
    hydrolase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEENGKGGV ENGRNSPLMS ALSHYAKPSL MDSEGETVKK MLEDTSPTNV DIDRNYKGPT  60
   61 LSLPLDKPQV AKMIEAFKVN KVLHPKYVLM ILHEARKIFK AMPSVSRIST SISNQVTICG 120
  121 DLHGKFDDLC IILYKNGYPS VDNPYIFNGD FVDRGGQSIE VLCVLFALVI VDPMSIYLNR 180
  181 GNHEDHIMNL RYGFIKELST KYKDLSTPIT RLLEDVFSWL PIATIIDRDI FVVHGGISDQ 240
  241 TEVSKLDKIP RHRFQSVLRP PVNKGMESEK ENSAVNVDEW KQMLDIMWSD PKQNKGCWPN 300
  301 VFRGGGSYFG ADITASFLEK HGFRLLVRSH ECKFEGYEFS HNNTCLTVFS ASNYYETGSN 360
  361 RGAYVKFIGK SKQPHFVQYM ASKTHRKSTL RERLGVVEES AVKELKEKLS SFHTDLQKEF 420
  421 EIMDIEKSGK LPILKWSDCV ERITGLNLPW IALAPKVATL SEDGKYVMYK EDRRIAQVGG 480
  481 THAQEKDIVE SLYRHKSTLE TLFRFMDKDN SGQVSMKEFI DACEVLGKYT KRPLQTDYIS 540
  541 QIAESIDFNK DGFIDLNELL EAFRLVDRPL LR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..392] PSI-BLAST 92.69897 PP5 structure
    2 View Details [393..572] PSI-BLAST 29.69897 Crystal structure of anthrax edema factor (EF) in complex with calmodulin and pyrophosphate

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  11.6417995308386 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  10.6440947462013 bayes_pls_golite062009
  • phosphatase activity
    		•  10.5525832502704 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  10.3702645338723 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  9.02791306892273 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  6.04386346716682 bayes_pls_golite062009
  • myosin phosphatase activity
    		•  5.31703100176823 bayes_pls_golite062009
  • hydrolase activity
    		•  3.13006743434485 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.68552051869632 bayes_pls_golite062009
  • kinase activity
    		•  1.67788383575784 bayes_pls_golite062009
  • structural molecule activity
    		•  1.5850868178597 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.57807175808088 bayes_pls_golite062009
  • protein kinase activity
    		•  1.4514460578232 bayes_pls_golite062009
  • binding
    		•  1.44538582463569 bayes_pls_golite062009
  • catalytic activity
    		•  1.39852585255405 bayes_pls_golite062009
  • transferase activity
    		•  1.3407391509244 bayes_pls_golite062009
  • protein binding
    		•  1.33435965029646 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • signal transducer activity
    		•  1.08090214431427 bayes_pls_golite062009
  • calmodulin binding
    		•  0.77173071932406 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.66803085638835 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.528189469950839 bayes_pls_golite062009
    2
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.47426847861728 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  6.37104157544514 bayes_pls_golite062009
  • phosphatase activity
    		•  6.28157965296365 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.17799259119197 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.11186887221409 bayes_pls_golite062009
  • calcium-dependent protein serine/threonine phosphatase activity
    		•  4.03747238142966 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.49668552859347 bayes_pls_golite062009
  • motor activity
    		•  3.25814691068414 bayes_pls_golite062009
  • binding
    		•  3.17556402087346 bayes_pls_golite062009
  • G-protein beta/gamma-subunit binding
    		•  3.05549386641848 bayes_pls_golite062009
  • actin binding
    		•  2.93015079033749 bayes_pls_golite062009
  • tubulin binding
    		•  2.51210014078446 bayes_pls_golite062009
  • microfilament motor activity
    		•  2.31015572544973 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.23156041569913 bayes_pls_golite062009
  • protein binding
    		•  2.21291432166051 bayes_pls_golite062009
  • structural constituent of muscle
    		•  2.20727612600932 bayes_pls_golite062009
  • cation binding
    		•  2.19699888218864 bayes_pls_golite062009
  • metal ion binding
    		•  2.19699888218864 bayes_pls_golite062009
  • ion binding
    		•  2.18936780190991 bayes_pls_golite062009
  • microtubule binding
    		•  2.17136406283012 bayes_pls_golite062009
  • structural molecule activity
    		•  2.02132683356917 bayes_pls_golite062009
  • DNA binding
    		•  1.73924929536227 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.53225451586959 bayes_pls_golite062009
  • myosin binding
    		•  1.52005099664686 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.51057181410195 bayes_pls_golite062009
  • kinase activity
    		•  1.48008348280256 bayes_pls_golite062009
  • calcium ion binding
    		•  1.40919295397643 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  1.39855027520112 bayes_pls_golite062009
  • actin filament binding
    		•  1.39015845077273 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.34982153616582 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.11607939838219 bayes_pls_golite062009
  • signal transducer activity
    		•  1.11607939838219 bayes_pls_golite062009
  • transferase activity
    		•  1.00143834284844 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.993476325956511 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • phosphatase regulator activity
    		•  0.87149881541475 bayes_pls_golite062009
  • protein phosphatase regulator activity
    		•  0.822713961141111 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.666488715029225 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.61866037435065 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.438908712437433 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.369738999181035 bayes_pls_golite062009
  • N-terminal myristoylation domain binding
    		•  0.36557202881933 bayes_pls_golite062009
  • hydrolase activity
    		•  0.275235036575339 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.20908131617536 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.116648335890738 bayes_pls_golite062009
  • actin monomer binding
    		•  0.0701886284348601 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle