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Protein Overview: nhr-19

General Information:
Name(s) found: nhr-19 / CE30271 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00003618 locus:nhr-19 Nuclear hormone receptor family member nhr-19 status:Confirmed UniProt:Q09528 protein_id:CAA87381.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 477 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: regulation of transcription, DNA-dependent [IEALink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    transcription factor activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    steroid hormone receptor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]
    steroid binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTVFQTMPT FLAGLNIANF GAATSQFPKL ESEITAPRQS MSTAFQKMPT FTSVISVPSI  60
   61 AAIAPQMPSV KPEKGVIGQC LICGEPSTGK HYGIVACLGC KTFFRRAVVQ RQDTECKREK 120
  121 PCDVTTMARK ACRACRYRKC LESGMSKEAL QPRRDLIGCR RIRSRPSCST STPTPPRPQV 180
  181 EDKSQYLTLL ENLTTIDDRL RKKKLEVVAS RQAAVDLAVL AKQGCMSITD TSGPSTSRYV 240
  241 PGGTSPNGGD HKMMVMLGTD ISVSTQSELL MMLEWTRTLP VFASLPVQDR SVILKRFAVH 300
  301 CLILEHGYYT AQANIDDVWL ITNGTCMPRN VEKLEEGCKI SVSADRRWRQ EKLYKQMTDC 360
  361 CIDEVATPLR NLKLSPQEIV VIKIIVLFNC GCSSDYSEIT EASRRIVLTF RNKVVSALFA 420
  421 YYESVGLQNY AERFGNLVLM LSGVSSAASS MLEAYQVMRL FKITPFDPLS QELLFNI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..77] MSA 1.549996 View MSA. No confident structure predictions are available.
    2 View Details [78..197] PSI-BLAST 23.0 No description for 2hanB was found.
    3 View Details [198..477] PSI-BLAST 47.154902 Retinoid-X receptor alpha (RXR-alpha)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.47256374293954 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription activator activity
    		•  2.9532663930699 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.72967350701574 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.55186574506963 bayes_pls_golite062009
  • protein binding
    		•  2.44501340584871 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.40923942043513 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.31171425360207 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.26452462867497 bayes_pls_golite062009
  • transporter activity
    		•  0.768214707487563 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.644659911825478 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.61572149323953 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.50876329665586 bayes_pls_golite062009
  • structural molecule activity
    		•  0.441960874303873 bayes_pls_golite062009
  • receptor activity
    		•  0.230063209127305 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.187612502757984 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.53061626347066 bayes_pls_golite062009
  • DNA binding
    		•  4.92165988569962 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.78024150262074 bayes_pls_golite062009
  • transcription activator activity
    		•  4.53302455129434 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  4.11614358606713 bayes_pls_golite062009
  • transcription factor activity
    		•  4.0914094580319 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  3.89763470197726 bayes_pls_golite062009
  • binding
    		•  3.85318710398432 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.26215649008108 bayes_pls_golite062009
  • protein binding
    		•  3.21524787168952 bayes_pls_golite062009
  • transcription activator binding
    		•  2.98235973123409 bayes_pls_golite062009
  • transcription factor binding
    		•  2.68044489404568 bayes_pls_golite062009
  • receptor activity
    		•  2.62895787183554 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.38308182853979 bayes_pls_golite062009
  • steroid hormone receptor activity
    		•  2.30195937604451 bayes_pls_golite062009
  • transcription coactivator activity
    		•  2.27959329058894 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.04709877069886 bayes_pls_golite062009
  • signal transducer activity
    		•  2.04709877069886 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.73827483890179 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  1.60419100774741 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.34794228300778 bayes_pls_golite062009
  • promoter binding
    		•  1.28787959668198 bayes_pls_golite062009
  • retinoic acid receptor binding
    		•  1.28118886948947 bayes_pls_golite062009
  • palmitoyl-CoA hydrolase activity
    		•  1.23181585568439 bayes_pls_golite062009
  • retinoid X receptor binding
    		•  1.06987052034846 bayes_pls_golite062009
  • hormone receptor binding
    		•  0.95284349923679 bayes_pls_golite062009
  • ecdysteroid hormone receptor activity
    		•  0.896626405427199 bayes_pls_golite062009
  • retinoic acid receptor activity
    		•  0.853869057774515 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.797229273848179 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.584337936981041 bayes_pls_golite062009
  • protein N-terminus binding
    		•  0.57701453824007 bayes_pls_golite062009
  • thyroid hormone receptor activity
    		•  0.49784404390361 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.47826452126899 bayes_pls_golite062009
  • lipid binding
    		•  0.475303782949439 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.45265806678057 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.42652610679613 bayes_pls_golite062009
  • receptor binding
    		•  0.418843034756825 bayes_pls_golite062009
  • ligand-regulated transcription factor activity
    		•  0.202197503742221 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  0.15737167800277 bayes_pls_golite062009
  • catalytic activity
    		•  0.106902059021677 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.34

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle