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Protein Overview: unc-89

General Information:
Name(s) found: unc-89 / CE30426 [WormBase]
Description(s) found:
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  • WBGene00006820 locus:unc-89 Muscle M-line assembly protein unc-89 status:Partially_confirmed UniProt:O01761 protein_id:CCD63864.1 [WormBase]
  • gi|71980586|ref|NP_001020984.1| UNCoordinated family member (unc-89) [Caenorhabditis elegans] [NCBI NR]
  • sp|O01761|UN89_CAEEL Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) [NCBI NR]
  • ref|NP_491290.2| UNCoordinated locomotion UNC-89, PHarynx Muscle abnormal PHM-1, UNC-89 (unc-89) [Caenorhabditis elegans] [NCBI NR]
  • gi|20198774|gb|AAB54132.2| Uncoordinated protein 89, isoform a, partially confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • (O01761) Muscle M-line assembly protein unc-89 (Uncoordinated protein 89) [Swiss-Prot]
  • [wormpep79.fasta]
  • CE30426 WBGene00006820 locus:unc-89 immunoglobin-like protein status:Partially_confirmed SW:O01761 protein_id:AAB54132.2 [wormpep150.fasta]
  • 30426 WBGene00006820 locus:unc-89 immunoglobin-like protein status:Partially_confirmed SW:O01761 protein_id:AAB54132.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • UNCoordinated locomotion UNC-89, PHarynx Muscle abnormal PHM-1, UNC-89 (unc-89) [Caenorhabditis elegans]gi|20198774|gb|AAB54132.2| Uncoordinated protein 89, isoform a [Caenorhabditis elegans]gi|29428125|sp|O01761|UN89_CAEEL Muscle M-line assembly protei [nrdb_11152004_Chlamydomonas]
  • locus:unc-89 immunoglobin-like protein status:Partially_confirmed SW:O01761 protein_id:AAB54132.2 [wormpep115.fasta.reversed]
  • CE30426 locus:unc-89 immunoglobin-like protein status:Partially_confirmed [wormpep80.hongbin]
  • CE30426 WBGene00006820 locus:unc-89 immunoglobin-like protein status:Partially_confirmed UniProt:UNC89_CAEEL protein_id:AAB54132.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE30426 WBGene00006820 locus:unc-89 immunoglobin-like protein status:Partially_confirmed UniProt:UNC89_CAEEL protein_id:AAB54132.2| [wormORF-contam.fasta]
  • UNCoordinated family member (unc-89) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Uncoordinated protein 89, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE30426 WBGene00006820 locus:unc-89 immunoglobin-like protein status:Partially_confirmed UniProt:O01761 protein_id:AAB54132.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE30426 WBGene00006820 locus:unc-89 immunoglobin-like protein status:Partially_confirmed UniProt:O01761 protein_id:CCD63864.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE30426 WBGene00006820 locus:unc-89 status:Partially_confirmed UniProt:O01761 protein_id:CCD63864.1 Muscle M-line assembly protein unc-89 [wormpep246-ecoli-contam.fasta]
  • Isoform of O01761, Isoform a of Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 6632 amino acids

    Gene Ontology:
    Cellular Component: A band [IDALink to PubMed article]
    extracellular region [IEALink to PubMed article]
    intracellular [IEALink to PubMed article]
    proteinaceous extracellular matrix [IEALink to PubMed article]
    Biological Process: regulation of Rho protein signal transduction [IEALink to PubMed article]
    carbohydrate metabolic process [IEALink to PubMed article]
    DNA repair [IEALink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    regulation of cell growth [IEALink to PubMed article]
    protein amino acid dephosphorylation [IEALink to PubMed article]
    cell adhesion [IEALink to PubMed article]
    blood coagulation [IEALink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: magnesium ion binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    protein tyrosine phosphatase activity [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    Rho guanyl-nucleotide exchange factor activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]
    insulin-like growth factor binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASRRQKQFD RKYSSYRKFT ATEDVNYSTH SSRSSYRSES LTSRTDGRGR STSSEIIAGS  60
   61 ESRSYPVYIA IQDYTPDKED VEAIPLEQGQ IVEVLDKKNS VRWLVRTKAR PPRSGWVPGS 120
  121 YFETPTEFYK QRRRTREIEN VSLSDEQAAL VKRDQVYHEL LRSEEEFVSS LRTCVDDYIK 180
  181 VLDDPEVPEA VKKNREELTL NIPELYNFHA NVMLKGLNYY SDDPGKVGQT FVRLEKDFES 240
  241 HVEFYKQYAD TLKLLEEPEI KRFFEGLSAK NDAGASSFVD HVKEIADRMV QYQNYFKEFV 300
  301 KYSARAHGSS KSIQKALELV TTIPQRVHDL EFTNNLKQHP GDTGKLGRII RHDAFQVWEG 360
  361 DEPPKLRYVF LFRNKIMFTE QDASTSPPSY THYSSIRLDK YNIRQHTTDE DTIVLQPQEP 420
  421 GLPSFRIKPK DFETSEYVRK AWLRDIAEEQ EKYAAERDAI SMTATSEMTA SSVDFDMNAS 480
  481 DQQSEFSEWS GSRKSSLFPG PEEGGPPRKK VKSPPVISPT GSSTSIYSGG SSSIDWTTTG 540
  541 TTLEMQGTRV TRTQYGFRTL QESSAKMCLK VTGYPLPDIT WYKDDVQLHE DERHTFYSDE 600
  601 DGFFAMTIDP VQVTDTGRYT CMATNEYGQA STSAFFRVLK VEKEAAPPAF VTKLRDKECK 660
  661 EGDVIDFECE VEGWPEPELV WLVDDQPLRP SHDFRLQYDG QTAKLEIRDA QPDDTGVYTV 720
  721 KIQNEFGSIE SKAELFVQAD PDKNHVAPEF QATIEYVECD EGEEVRFKSV ITGDPNPEII 780
  781 WFINGKPLSE SEKVKFISED GICILTIKDV TRHFDGMVTC QGSNRLGSAS CDGRLKVRVP 840
  841 PAPPTFNKPL EDKTVQEKST VVFEVDVSGW PEPTLTFTLC GKELKNGEEG VEIVGHDGFY 900
  901 RISIPNTSMD KHDGEIVAKA QNEHGTAESR ARLTVEQEEE ESRSAPTFLK DIEDQTVKTG 960
  961 EFAVFETTVR GNPNPEVTWF INGHKMDQGS PGVKIEAHNH DHKLTIDSAQ YAGTVLCRAE1020
 1021 NAVGRFETKA RLVVLAPEKQ KKPPKFVEIL VDKTETVDNT VVFEVRVEGE PKPTVTWYLK1080
 1081 GEELKQSDRV EIREFDGSIK ISIKNIKIED AGEIRAVATN SEGSDETKAK LTVQKKPFAP1140
 1141 EFDLRPVSLT VEKGSEAVFS AHAFGIPLPT YEWSVNGRKV RDGQEGARVT RDESTVDGAS1200
 1201 ILTIDTATYY SEVNHLTISV VAENTLGAEE TGAQLTIEPK KESVVVEKQD LSSSEVQKEI1260
 1261 AQQVKEASPE ATTTITMETS LTSTKTTTMS TTEVTSTVGG VTVETKESES ESATTVIGGG1320
 1321 SGGVTEGSIS VSKIEVVSKT DSQTDVREGT PKRRVSFAEE ELPKEVIDSD RKKKKSPSPD1380
 1381 KKEKSPEKTE EKPASPTKKT GEEVKSPKEK SPASPTKKEK SPAAEEVKSP TKKEKSPSSP1440
 1441 TKKEKSPSSP TKKTGDEVKE KSPPKSPTKK EKSPEKPEDV KSPVKKEKSP DATNIVEVSS1500
 1501 ETTIEKTETT MTTEMTHESE ESRTSVKKEK TPEKVDEKPK SPTKKDKSPE KSITEEIKSP1560
 1561 VKKEKSPEKV EEKPASPTKK EKSPEKPASP TKKSENEVKS PTKKEKSPEK SVVEELKSPK1620
 1621 EKSPEKADDK PKSPTKKEKS PEKSATEDVK SPTKKEKSPE KVEEKPTSPT KKESSPTKKT1680
 1681 DDEVKSPTKK EKSPQTVEEK PASPTKKEKS PEKSVVEEVK SPKEKSPEKA EEKPKSPTKK1740
 1741 EKSPEKSAAE EVKSPTKKEK SPEKSAEEKP KSPTKKESSP VKMADDEVKS PTKKEKSPEK1800
 1801 VEEKPASPTK KEKTPEKSAA EELKSPTKKE KSPSSPTKKT GDESKEKSPE KPEEKPKSPT1860
 1861 PKKSPPGSPK KKKSKSPEAE KPPAPKLTRD LKLQTVNKTD LAHFEVVVEH ATECKWFLDG1920
 1921 KEITTAQGVT VSKDDQFEFR CSIDTTMFGS GTVSVVASNA AGSVETKTEL KVLETPKETK1980
 1981 KPEFTDKLRD MEVTKGDTVQ MDVIALHSPL YKWYQNGNLL EDGKNGVTIK NEENKSSLII2040
 2041 PNAQDSGKIT VEASNEVGSS ESSAQLTVNP PSTTPIVVDG PKSVTIKETE TAEFKATISG2100
 2101 FPAPTVKWTI NEKIVEESRT ITTIKTEDVY TLKISNAKIE QTGTVKVTAQ NSAGQDSKQA2160
 2161 DLKVEPNVKA PKFKSQLTDK VADEGEPLRW NLELDGPSPG TEVSWLLNGQ PLTKSDTVQV2220
 2221 VDHGDGTYHV TIAEAKPEMS GTLTAKAKNA AGECETSAKV TVNGGNKKPE FVQAPQNHET2280
 2281 TLEESVKFSA IVTGKPMPNV TWYLNNKKLI QSEEVKVKYV HETGKTSIRI QKPLMEHNGT2340
 2341 IRVEAENVSG KVQATAQLKV DKKTEVPKFT TNMDDRQVKE GEDVKFTANV EGYPEPSVAW2400
 2401 TLNGEPVSKH PNITVTDKDG EHTIEISAVT PEQAGELSCE ATNPVGSKKR DVQLAVKKVG2460
 2461 DAPTFAKNLE DRLITEGELT LMDAKLNIVK PKPKITWLKD GVEITSDGHY KIVEEEDGSL2520
 2521 KLSILQTKLE DKGRITIKAE SEFGVAECSA SLGVVKGRPM AKPAFQSDIA PINLTEGDTL2580
 2581 ECKLLITGDP TPFVKWYIGT QLVCATEDTE ISNANGVYTM KIHGVTADMT GKIKCVAYNK2640
 2641 AGEVSTEGPL KVVAPIPVEF ETSLCDATCR EGDTLKLRAV LLGEPEPVVS WYVNGKKLEE2700
 2701 SQNIKIHSEK GTYTVTIKDI TCDYSGQVVC EAINEYGKAT SEATLLVLPR GEPPDFLEWL2760
 2761 SNVRARTGTK VVHKVVFTGD PKPSLTWYIN NKEILNSDLY TIVTDDKTST LTINSFNPDV2820
 2821 HVGEIICKAE NDAGEVSCTA NMITYTSDMF SESESEAQAE EFVGDDLTED ESLREEMHRT2880
 2881 PTPVMAPKFI TKIKDTKAKK GHSAVFECVV PDTKGVCCKW LKDGKEIELI ARIRVQTRTG2940
 2941 PEGHITQELV LDNVTPEDAG KYTCIVENTA GKDTCEATLT VIESLEKKSE KKAPEFIVAL3000
 3001 QDKTTKTSEK VVLECKVIGE PKPKVSWLHD NKTITQESIT VESVEGVERV TITSSELSHQ3060
 3061 GKYTCIAENT EGTSKTEAFL TVQGEAPVFT KELQNKELSI GEKLVLSCSV KGSPQPHVDF3120
 3121 YSFSETTKVE TKITSSSRIA IEHDQTNTHW RMVISQITKE DIVSYKAIAT NSIGTATSTS3180
 3181 KITTKVEAPV FEQGLKKTSV KEKEEIKMEV KVGGSAPDVE WFKDDKPVSE DGNHEMKKNP3240
 3241 ETGVFTLVVK QAATTDAGKY TAKASNPAGT AESSAEAEVT QSLEKPTFVR ELVTTEVKIN3300
 3301 ETATLSVTVK GVPDPSVEWL KDGQPVQTDS SHVIAKVEGS GSYSITIKDA RLEDSGKYAC3360
 3361 RATNPAGEAK TEANFAVVKN LVPPEFVEKL SPLEVKEKES TTLSVKVVGT PEPSVEWFKD3420
 3421 DTPISIDNVH VIQKQTAVGS FSLTINDARQ GDVGIYSCRA RNEAGEALTT ANFGIIRDSI3480
 3481 PPEFTQKLRP LEVREQETLD LKVTVIGTPV PNVEWFKDDK PINIDNSHIF AKDEGSGHHT3540
 3541 LTIKQARGED VGVYTCKATN EAGEAKTTAN MAVQEEIEAP LFVQGLKPYE VEQGKPAELV3600
 3601 VRVEGKPEPE VKWFKDGVPI AIDNQHVIEK KGENGSHTLV IKDTNNADFG KYTCQATNKA3660
 3661 GKDETVGELK IPKYSFEKQT AEEVKPLFIE PLKETFAVEG DTVVLECKVN KESHPQIKFF3720
 3721 KNDQPVEIGQ HMQLEVLEDG NIKLTIQNAK KEDVGAYRCE AVNVAGKANT NADLKIQFAA3780
 3781 KVEEHVTDES GQLEEIGQFE TVGDTASSKT DTGRGAPEFV ELLRSCTVTE KQQAILKCKV3840
 3841 KGEPRPKIKW TKEGKEVEMS ARVRAEHKDD GTLTLTFDNV TQADAGEYRC EAENEYGSAW3900
 3901 TEGPIIVTLE GAPKIDGEAP DFLQPVKPAV VTVGETAVLE GKISGKPKPS VKWYKNGEEL3960
 3961 KPSDRVKIEN LDDGTQRLTV TNAKLDDMDE YRCEASNEFG DVWSDVTLTV KEPAQVAPGF4020
 4021 FKELSAIQVK ETETAKFECK VSGTKPDVKW FKDGTPLKED KRVHFESTDD GTQRLVIEDS4080
 4081 KTDDQGNYRI EVSNDAGVAN SKVPLTVVPS ETLKIKKGLT DVNVTQGTKI LLSVEVEGKP4140
 4141 KTVKWYKGTE TVTSSQTTKI VQVTESEYKL EIESAEMSDT GAYRVVLSTD SFSVESSATV4200
 4201 TVTKAAEKIS LPSFKKGLAD QSVPKGTPLV LEVEIEGKPK DVKWYKNGDE IKDGKVEDLG4260
 4261 NGKYRLTIPD FQEKDVGEYS VTAANEAGEI ESKAKVNVSA KPEIVSGLVP TTVKQGETAT4320
 4321 FNVKVKGPVK GVKWYKNGKE IPDAKTKDNG DGSYSLEIPN AQVEDAADYK VVVSNDAGDA4380
 4381 DSSAALTVKL ADDGKDKVKP EIVSGLIPTT VKQGETATFN VKVKGPVKQV KWYKNGKEIP4440
 4441 NAKAKDNGDG SYSLEIPNAQ LDDTADYKVV VSNDAGDADS SAALTVKLPG IAIVKGLEDA4500
 4501 EVPKGKKAVL QVETNKKPKE IKWYKNGKEI TPSDKAQPGS DGDNKPQLVI PDAGDDDAAE4560
 4561 YKVVLTDEDG NTADSSCALT VKLPAKEPKI IKGLEDQVVS IGSPIKLEIE TSGSPKTVKW4620
 4621 YKNGKELPGA AAKTIKIQKI DDNKYVLEIP SSVVEDTGDY KVEVANEAGS ANSSGKITVE4680
 4681 PKITFLKPLK DQSITEGENA EFSVETNTKP RIVKWYKNGQ EIKPNSRFII EQKTDTKYQL4740
 4741 VIKNAVRDDA DTYKIVLENT AGEAESSAQL TVKKAKAGLC KIVKGLEDQV VAKGAKMVFE4800
 4801 VKIQGEPEDV RWLRDANVIS AGANAIIEKI DDTTYRLIIP SADLKDAGEY TVEVINESGK4860
 4861 AKSDAKGEVD EKPEIVRGLE NIEIPEGDDD VFKVEVSAPV RQVKWYKNDQ EIKPNSHLEA4920
 4921 KKIGPKKYEL AINRAQLDDG ADYKVVLSNA AGDCDSSAAL TVVKPNVLKI VDGLKDVDVE4980
 4981 EPQPVELKVK VEGIPKVIKW YKNGQELKPD ADGFKFEEKP ESGEFSLTIP SSKKSDGGAY5040
 5041 RVVLGNDKGE VYSGSVVHVK SAKSSEPTSG ANFLSPLKDT EVEEGDMLTL QCTIAGEPFP5100
 5101 EVIWEKDGVV LQKDDRITMR VALDGTATLR IRSAKKSDIG QYRVTAKNEA GSATSDCKVT5160
 5161 VTEQGEQPSK PKFVIPLKTG AALPGDKKEF NVKVRGLPKP TLQWFLNGIP IKFDDRITLD5220
 5221 DMADGNYCLT IRDVREEDFG TLKCIAKNEN GTDETVCEFQ QGAGHDDGSR DDLRYPPRFN5280
 5281 VPLWDRRIPV GDPMFIECHV DANPTAEVEW FKDGKKIEHT AHTEIRNTVD GACRIKIIPF5340
 5341 EESDIGVYMC VAVNELGQAE TQATYQVEIL EHVEEEKRRE YAPKINPPLE DKTVNGGQPI5400
 5401 RLSCKVDAIP RASVVWYKDG LPLRADSRTS IQYEEDGTAT LAINDSTEED IGAYRCVATN5460
 5461 AHGTINTSCS VNVKVPKQEV KKEGEEPFFT KGLVDLWADR GDSFTLKCAV TGDPFPEIKW5520
 5521 YRNGQLLRNG PRTVIETSPD GSCSLTVNES TMSDEGIYRC EAENAHGKAK TQATAHVQMA5580
 5581 LGKTEKPKMD EGKPPKFILE LSDMSVSLGN VIDLECKVTG LPNPSVKWSK DGGPLIEDSR5640
 5641 FEWSNEASKG VYQLRIKNAT VHDEGTYRCV ATNENGSATT KSFVRMDDGL GSGVVTASQP5700
 5701 PRFTLKMGDV RTTEGQPLKL ECKVDASPLP EMVWYKDGAI VTPSDRIQIS LSPDGVATLL5760
 5761 IPSCVYDDDG IYRVIATNPS GTAQDKGTAT VKKLPRDSGA RRSADRDVFD ANKAPKLMEP5820
 5821 LENIRIPEKQ SFRLRCKFSG DPKPTIKWFK DGERVFPYGR LQLIESPDGV CELVVDSATR5880
 5881 QDAGGYRCVA ENTYGSARTS CDVNVIRGDR KPRDIDSSIR EGKAPGFTTP LTIRRAKPGD5940
 5941 SVTFECLPFG NPFPSIKWLK DGLELFSDEK IKMEAAADGT QRLILSDVTF LSEGYFRCVA6000
 6001 TNEHGTASTK AELVIEGDRT IGSRPLPEVN GEPEECKPRI RRGLYNMSIH EGNVVEMIVC6060
 6061 ATGIPTPTVK WYKDGQEIVG DGPDGKRVIF TDERGIHHLV IVNASPDDEG EYSLEATNKL6120
 6121 GSAKTEGSLN IIRPRHIADA DERGGMPFPP GFVRQLKNKH VFNHMPTIFD CLVVGHPAPE6180
 6181 VEWFHNGKKI VPGGRIKIQS CGGGSHALII LDTTLEDAGE YVATAKNSHG SASSSAVLDV6240
 6241 TVPFLDSIKF NGEIDVTPYL TEEYGFKKLN TASLPTPPDR GPFIKEVTGH YLTLSWIPTK6300
 6301 RAPPRYPQVT YVIEIRELPE KQWSLLEYNI PEPVCKVRNL ELGKSYQFRV RAENIYGISD6360
 6361 PSPASPPSRL MAPPQPVFDR RTNKVIPLLD PYAEKALDMR YSEQYACAPW FSPGVVEKRY6420
 6421 CAENDTLTIV LNVSGFPDPD IKWKFRGWDI DTSSPTSKCK VYTYGGSETT LAITGFSKEN6480
 6481 VGQYQCFAKN DYGDAQQNIM VDLATRPNFI QPLVNKTFSS AQPMRMDVRV DGEPFPELKW6540
 6541 MKEWRPIVES SRIKFVQDGP YLCSLIINDP MWRDSGIYSC VAVNDAGQAT TSCTVTVEAE6600
 6601 GDYNDVELPR RRVTIESRRV RELYEISEKD EK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle