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Protein Overview: pkc-1

General Information:
Name(s) found: pkc-1 / CE29092 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00004032 locus:pkc-1 Protein kinase C-like 1B status:Confirmed UniProt:P34885 protein_id:CAB00101.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 707 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: chemotaxis [IMP]
    protein amino acid phosphorylation [IEALink to PubMed article]
    neurotransmitter secretion [IMP]
    positive regulation of locomotion [IMP]
    Molecular Function: ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]
    protein kinase C activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLFTGTVRVR VLEARQLRPT EWSRRFRQDE AATAAIDSYV NVDWDEYHIG KTQVRPKTNE  60
   61 PRWNEEFTAS GVHQGKAIGF SVFHSCVMPP DDFVANTRIA FDQLKIGSAN DIWVDLEPHG 120
  121 QLHVVVEMHG TNVEDVHSHN KTRVFKERTN AFNDRQRRGA MRRKIHEVTG HKFMALFLRQ 180
  181 PTFCAHCKEF IWGIGKQGYQ CQICTVVVHK RCHEDVVWKC PGNKADAVEE LGKEIQETGA 240
  241 GRFNINMPHR FSVHSYKRPT FCDHCGSMLY GLINQGLQCS TCKLNVHKRC QRNVANNCGI 300
  301 NAKQMAAELA QLGLTGDKMS IRSKKKPSIM TDTSTDISGS SNSENSGYLQ QISEDDSGTT 360
  361 SSRSASKVPG GTLSIHDFTF MKVLGKGSFG KVMLAERKGT DEVYAIKILK KDVIVQDDDV 420
  421 ECTMCEKRIL SLAAKHPFLT ALHSSFQTSD RLFFVMEYVN GGDLMFQIQR ARKFDESRAR 480
  481 FYAAEVTCAL QFLHRNDVIY RDLKLDNILL DAEGHCRLAD FGMCKEGINK DNLTSTFCGT 540
  541 PDYIAPEILQ EMEYGVSVDW WALGVLMYEM MAGQPPFEAD NEDDLFEAIL NDDVLYPVWL 600
  601 SKEAVNILKA FMTKNAGKRL GCVVSQGGED AIRAHPFFRE IDWDALESRQ VKPPFKPKIK 660
  661 SKRDANNFDS DFTKEEPVLT PSDPAVVRAI NQDEFRGFSF INPHFTY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..137] PSI-BLAST 31.154902 Domain from protein kinase C epsilon
    2 View Details [138..247] PSI-BLAST 12.522879 Crystal Structure of the Human Beta2-Chimaerin
    3 View Details [248..625] PSI-BLAST 36.0 No description for 2ozoA was found.
    4 View Details [626..707] PSI-BLAST 88.39794 No description for 2i0eA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • calcium-dependent phospholipid binding
    		•  4.44639260287301 bayes_pls_golite062009
  • binding
    		•  2.77482286467294 bayes_pls_golite062009
  • phospholipid binding
    		•  2.74013385479058 bayes_pls_golite062009
  • protein binding
    		•  2.38962673708753 bayes_pls_golite062009
  • neurexin binding
    		•  1.99616093461872 bayes_pls_golite062009
  • lipid binding
    		•  1.47484095830847 bayes_pls_golite062009
  • receptor activity
    		•  1.33810899162617 bayes_pls_golite062009
  • transporter activity
    		•  1.2628067945512 bayes_pls_golite062009
  • signal transducer activity
    		•  1.10701462579828 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.10701462579828 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.816751946072324 bayes_pls_golite062009
  • syntaxin-1 binding
    		•  0.655976398483981 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.640971174993756 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.632268019524323 bayes_pls_golite062009
  • hydrolase activity
    		•  0.501946993060588 bayes_pls_golite062009
  • SNARE binding
    		•  0.3731056408292 bayes_pls_golite062009
  • profilin binding
    		•  0.32399339703241 bayes_pls_golite062009
  • calmodulin binding
    		•  0.26906635924237 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.24011514942644 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.0536444296215369 bayes_pls_golite062009
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  3.34605625047342 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.86705824967236 bayes_pls_golite062009
  • binding
    		•  2.79128751898373 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.70614727793157 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.68579854252375 bayes_pls_golite062009
  • protein binding
    		•  2.34145982999922 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.10625597744594 bayes_pls_golite062009
  • DNA binding
    		•  2.06132216820898 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.06038764955701 bayes_pls_golite062009
  • kinase activity
    		•  2.03632850156074 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.9750017471254 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.95738547986197 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.91441035614579 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.8531437045627 bayes_pls_golite062009
  • protein kinase activity
    		•  1.62921423829738 bayes_pls_golite062009
  • transferase activity
    		•  1.4550521488922 bayes_pls_golite062009
  • transcription factor activity
    		•  1.39657429296564 bayes_pls_golite062009
  • signal transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.25507073225414 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.10685156896266 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.09070479183477 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.958295643211986 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.956859696337723 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.717730683557543 bayes_pls_golite062009
  • kinase binding
    		•  0.494958567742569 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.298334474872045 bayes_pls_golite062009
  • catalytic activity
    		•  0.194464246602439 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle