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Protein Overview: mes-2

General Information:
Name(s) found: mes-2 / CE28067 [WormBase]
Description(s) found:
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  • WBGene00003220 locus:mes-2 Histone-lysine N-methyltransferase mes-2 status:Confirmed UniProt:O17514 protein_id:CAB05589.2 [WormBase]
  • gi|71993336|ref|NP_496992.3| Maternal Effect Sterile family member (mes-2) [Caenorhabditis elegans] [NCBI NR]
  • gi|29427556|sp|O17514.2|MES2_CAEEL RecName: Full=Histone-lysine N-methyltransferase mes-2; AltName: Full=Maternal-effect sterile protein 2; AltName: Full=E(z) homolog [NCBI NR]
  • gi|14530536|emb|CAB05589.2| C. elegans protein R06A4.7, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|14530433|emb|CAB04199.2| C. elegans protein R06A4.7, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • Histone-lysine N-methyltransferase mes-2 OS=Caenorhabditis elegans GN=mes-2 PE=1 SV=2 [Swiss-Prot]
  • [wormpep67.fasta]
  • Hypothetical protein R06A4.7 [Caenorhabditis elegans]gi|14530536|emb|CAB05589.2| Hypothetical protein R06A4.7 [Caenorhabditis elegans]gi|29427556|sp|O17514|MES2_CAEEL Polycomb protein mes-2 (Maternal-effect sterile 2 protein) (E(z) homolog) [nrdb_11152004_Chlamydomonas]
  • CE28067 WBGene00003220 locus:mes-2 SET domain status:Confirmed SW:O17514 protein_id:CAB05589.2 [wormpep150.fasta]
  • 28067 WBGene00003220 locus:mes-2 SET domain status:Confirmed SW:O17514 protein_id:CAB05589.2 [wormpep130-phg-ecoli-orf-rand.fasta]
  • locus:mes-2 SET domain status:Confirmed SW:O17514 protein_id:CAB05589.2 [wormpep115.fasta.reversed]
  • CE28067 locus:mes-2 SET domain status:Confirmed TR:O62335 protein_id:CAB05589.2 [wormpep80.hongbin]
  • CE28067 WBGene00003220 locus:mes-2 SET domain status:Confirmed UniProt:O17514 protein_id:CAB05589.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE28067 WBGene00003220 locus:mes-2 SET domain status:Confirmed UniProt:O17514 protein_id:CAB05589.2| [wormORF-contam.fasta]
  • Hypothetical protein R06A4.7 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Polycomb protein mes-2 (Maternal-effect sterile protein 2) (E(z) homolog) [nr-271106-contam.fasta]
  • Maternal Effect Sterile family member (mes-2) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE28067 WBGene00003220 locus:mes-2 status:Confirmed UniProt:O17514 protein_id:CAB05589.2 Histone-lysine N-methyltransferase mes-2 [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 773 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    nucleosome [IDALink to PubMed article]
    Biological Process: germ cell development [IMPLink to PubMed article]
    chromatin modification [IEALink to PubMed article]
    germ-line stem cell division [IMPLink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [ISSLink to PubMed article]
    Molecular Function: histone-lysine N-methyltransferase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNSEPSTST PSGKTKKRGK KCETSMGKSK KSKNLPRFVK IQPIFSSEKI KETVCEQGIE  60
   61 ECKRMLKGHF NAIKDDYDIR VKDELDTDIK DWLKDASSSV NEYRRRLQEN LGEGRTIAKF 120
  121 SFKNCEKYEE NDYKVSDSTV TWIKPDRTEE GDLMKKFRAP CSRIEVGDIS PPMIYWVPIE 180
  181 QSVATPDQLR LTHMPYFGDG IDDGNIYEHL IDMFPDGIHG FSDNWSYVND WILYKLCRAA 240
  241 LKDYQGSPDV FYYTLYRLWP NKSSQREFSS AFPVLCENFA EKGFDPSSLE PWKKTKIAEG 300
  301 AQNLRNPTCY ACLAYTCAIH GFKAEIPIEF PNGEFYNAML PLPNNPENDG KMCSGNCWKS 360
  361 VTMKEVSEVL VPDSEEILQK EVKIYFMKSR IAKMPIEDGA LIVNIYVFNT YIPFCEFVKK 420
  421 YVDEDDEESK IRSCRDAYHL MMSMAENVSA RRLKMGQPSN RLSIKDRVNN FRRNQLSQEK 480
  481 AKRKLRHDSL RIQALRDGLD AEKLIREDDM RDSQRNSEKV RMTAVTPITA CRHAGPCNAT 540
  541 AENCACRENG VCSYMCKCDI NCSQRFPGCN CAAGQCYTKA CQCYRANWEC NPMTCNMCKC 600
  601 DAIDSNIIKC RNFGMTRMIQ KRTYCGPSKI AGNGLFLLEP AEKDEFITEY TGERISDDEA 660
  661 ERRGAIYDRY QCSYIFNIET GGAIDSYKIG NLARFANHDS KNPTCYARTM VVAGEHRIGF 720
  721 YAKRRLEISE ELTFDYSYSG EHQIAFRMVQ TKERSEKPSR PKSQKLSKPM TSE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..76] deduced N/A No confident structure predictions are available.
    2 View Details [77..351] MSA 3.056947 View MSA. No confident structure predictions are available.
    3 View Details [352..456] deduced N/A No confident structure predictions are available.
    4 View Details [457..773] PSI-BLAST 40.0 No description for 2igqA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle