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Protein Overview: sir-2.4

General Information:
Name(s) found: sir-2.4 / CE27656 [WormBase]
Description(s) found:
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  • WBGene00004803 locus:sir-2.4 status:Partially_confirmed UniProt:Q95Q89 protein_id:AAK68163.1 [WormBase]
  • gi|17505510|ref|NP_491733.1| yeast SIR related family member (sir-2.4) [Caenorhabditis elegans] [NCBI NR]
  • gi|14573765|gb|AAK68163.1|U97193_3 Yeast sir related protein 2.4 [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE27656 WBGene00004803 locus:sir-2.4 status:Predicted TR:Q95Q89 protein_id:AAK68163.1 [wormpep150.fasta]
  • 27656 WBGene00004803 locus:sir-2.4 status:Predicted TR:Q95Q89 protein_id:AAK68163.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • yeast SIR related (sir-2.4) [Caenorhabditis elegans]gi|14573765|gb|AAK68163.1| Yeast sir related protein 2.4 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • locus:sir-2.4 status:Predicted TR:Q95Q89 protein_id:AAK68163.1 [wormpep115.fasta.reversed]
  • CE27656 locus:sir-2.4 status:Predicted [wormpep80.hongbin]
  • CE27656 WBGene00004803 locus:sir-2.4 status:Predicted UniProt:Q95Q89_CAEEL protein_id:AAK68163.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE27656 WBGene00004803 locus:sir-2.4 status:Predicted UniProt:Q95Q89_CAEEL protein_id:AAK68163.1| [wormORF-contam.fasta]
  • yeast SIR related family member (sir-2.4) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Yeast sir related protein 2.4 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE27656 WBGene00004803 locus:sir-2.4 status:Partially_confirmed UniProt:Q95Q89 protein_id:AAK68163.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
    • Organism: Caenorhabditis elegans
    Length: 299 amino acids

    Gene Ontology:
    Cellular Component: chromatin silencing complex [IEALink to PubMed article]
    Biological Process: regulation of transcription, DNA-dependent [IEALink to PubMed article]
    chromatin silencing [IEALink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSAKYKTVS SKKRFFKHNS IIFLIQNFQI RDTETEIIEK LRTLYNHFVQ AKQTGKPIFV  60
   61 LIGAGVSTGS KLPDFRGKQG VWTLQAEGKH AEGVDFQVAR PGVSHKSILA LHKAGYIKTI 120
  121 ITQNVDGLDR KVGIPVEDLI EVHGNLFLEV CQSCFSEYVR EEIVMSVGLC PTGRNCEGNK 180
  181 RTGRSCRGKL RDATLDWDTE ISLNHLDRIR KAWKQTSHLL CIGTSLEIIP MGSLPLDAKS 240
  241 KGIKTTTINY QETAHEKIVE TAIHADVKLI LYSLCNALGV NVDLGDDLPD EVPIPLKIS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..299] PSI-BLAST 64.69897 AF1676, Sir2 homolog (Sir2-AF1?)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  1.35219834199205 bayes_pls_golite062009
  • catalytic activity
    		•  1.1096503360938 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.798062126041325 bayes_pls_golite062009
  • DNA binding
    		•  0.76914567174665 bayes_pls_golite062009
  • binding
    		•  0.725903081591757 bayes_pls_golite062009
  • NAD-dependent histone deacetylase activity
    		•  0.5748958272185 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  0.5748958272185 bayes_pls_golite062009
  • histone deacetylase activity
    		•  0.417995543117071 bayes_pls_golite062009
  • protein deacetylase activity
    		•  0.40196400477198 bayes_pls_golite062009
  • deacetylase activity
    		•  0.154033944993939 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle