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View Structure Prediction Details

Protein: sir-2.4
Organism: Caenorhabditis elegans
Length: 299 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for sir-2.4.

Description E-value Query
Range
Subject
Range
gi|76622231, gi|... - gi|76622231|ref|XP_615499.2| PREDICTED: similar to Sirtuin (silent mating type information regulatio...
264.0 [0..28] [286..21]

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Predicted Domain #1
Region A:
Residues: [1-299]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSAKYKTVS SKKRFFKHNS IIFLIQNFQI RDTETEIIEK LRTLYNHFVQ AKQTGKPIFV  60
   61 LIGAGVSTGS KLPDFRGKQG VWTLQAEGKH AEGVDFQVAR PGVSHKSILA LHKAGYIKTI 120
  121 ITQNVDGLDR KVGIPVEDLI EVHGNLFLEV CQSCFSEYVR EEIVMSVGLC PTGRNCEGNK 180
  181 RTGRSCRGKL RDATLDWDTE ISLNHLDRIR KAWKQTSHLL CIGTSLEIIP MGSLPLDAKS 240
  241 KGIKTTTINY QETAHEKIVE TAIHADVKLI LYSLCNALGV NVDLGDDLPD EVPIPLKIS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.69897
Match: 1m2gA
Description: AF1676, Sir2 homolog (Sir2-AF1?)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 1.35219834199205 bayes_pls_golite062009
catalytic activity 1.1096503360938 bayes_pls_golite062009
nucleic acid binding 0.798062126041325 bayes_pls_golite062009
DNA binding 0.76914567174665 bayes_pls_golite062009
binding 0.725903081591757 bayes_pls_golite062009
NAD-dependent histone deacetylase activity 0.5748958272185 bayes_pls_golite062009
NAD-dependent protein deacetylase activity 0.5748958272185 bayes_pls_golite062009
histone deacetylase activity 0.417995543117071 bayes_pls_golite062009
protein deacetylase activity 0.40196400477198 bayes_pls_golite062009
deacetylase activity 0.154033944993939 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle