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Protein Overview: skn-1

General Information:
Name(s) found: skn-1 / CE27591 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00004804 locus:skn-1 Protein skinhead-1 status:Confirmed UniProt:P34707 protein_id:CCD62212.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 623 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article][IEALink to PubMed article]
    Biological Process: response to oxidative stress [IEPLink to PubMed article][IMPLink to PubMed article]
    response to heat [IEPLink to PubMed article][IMPLink to PubMed article]
    determination of adult lifespan [IMPLink to PubMed article]
    embryonic pattern specification [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    cell fate specification [IMPLink to PubMed article]
    mesendoderm development [TASLink to PubMed article]
    response to herbicide [IEPLink to PubMed article][IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    RNA polymerase II transcription factor activity, enhancer binding [IDALink to PubMed article]
    double-stranded DNA binding [IDALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]
    protein dimerization activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGSSRRQRS TSATRRDDKR RRRQCFSSVA DDEEETTSIY GVSSIFIWIL ATSSLILVIS  60
   61 SPSSNTSIQS SSYDRITTKH LLDNISPTFK MYTDSNNRNF DEVNHQHQQE QDFNGQSKYD 120
  121 YPQFNRPMGL RWRDDQRMME YFMSNGPVET VPVMPILTEH PPASPFGRGP STERPTTSSR 180
  181 YEYSSPSLED IDLIDVLWRS DIAGEKGTRQ VAPADQYECD LQTLTEKSTV APLTAEENAR 240
  241 YEDLSKGFYN GFFESFNNNQ YQQKHQQQQR EQIKTPTLEH PTQKAELEDD LFDEDLAQLF 300
  301 EDVSREEGQL NQLFDNKQQH PVINNVSLSE GIVYNQANLT EMQEMRDSCN QVSISTIPTT 360
  361 STAQPETLFN VTDSQTVEQW LPTEVVPNDV FPTSNYAYIG MQNDSLQAVV SNGQIDYDHS 420
  421 YQSTGQTPLS PLIIGSSGRQ QQTQTSPGSV TVTATATQSL FDPYHSQRHS FSDCTTDSSS 480
  481 TCSRLSSESP RYTSESSTGT HESRFYGKLA PSSGSRYQRS SSPRSSQSSI KIARVVPLAS 540
  541 GQRKRGRQSK DEQLASDNEL PVSAFQISEM SLSELQQVLK NESLSEYQRQ LIRKIRRRGK 600
  601 NKVAARTCRQ RRTDRHDKMS HYI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..186] MSA 1.128996 View MSA. No confident structure predictions are available.
    2 View Details [187..366] MSA 2.156993 View MSA. No confident structure predictions are available.
    3 View Details [367..538] MSA 5.158995 View MSA. No confident structure predictions are available.
    4 View Details [539..623] PSI-BLAST 29.69897 Skn-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56528092116191 bayes_pls_golite062009
  • DNA binding
    		•  4.39236205038451 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.27517034548789 bayes_pls_golite062009
  • transcription factor activity
    		•  3.86034396858961 bayes_pls_golite062009
  • binding
    		•  3.28937567198027 bayes_pls_golite062009
  • protein binding
    		•  2.82801305666365 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.80824533696213 bayes_pls_golite062009
  • transcription activator activity
    		•  2.80670414213103 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  1.87549895714075 bayes_pls_golite062009
  • protein dimerization activity
    		•  1.4553301455216 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.12585390480455 bayes_pls_golite062009
  • transcription factor binding
    		•  0.495155180229128 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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