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View Structure Prediction Details

Protein: skn-1
Organism: Caenorhabditis elegans
Length: 623 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for skn-1.

Description E-value Query
Range
Subject
Range
gi|109114151 - gi|109114151|ref|XP_001086482.1| PREDICTED: nuclear factor (erythroid-derived 2)-like 1 isoform 8 [M...
316.0 [0..66] [614..68]

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Predicted Domain #1
Region A:
Residues: [1-186]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGSSRRQRS TSATRRDDKR RRRQCFSSVA DDEEETTSIY GVSSIFIWIL ATSSLILVIS  60
   61 SPSSNTSIQS SSYDRITTKH LLDNISPTFK MYTDSNNRNF DEVNHQHQQE QDFNGQSKYD 120
  121 YPQFNRPMGL RWRDDQRMME YFMSNGPVET VPVMPILTEH PPASPFGRGP STERPTTSSR 180
  181 YEYSSP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [187-366]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLEDIDLIDV LWRSDIAGEK GTRQVAPADQ YECDLQTLTE KSTVAPLTAE ENARYEDLSK  60
   61 GFYNGFFESF NNNQYQQKHQ QQQREQIKTP TLEHPTQKAE LEDDLFDEDL AQLFEDVSRE 120
  121 EGQLNQLFDN KQQHPVINNV SLSEGIVYNQ ANLTEMQEMR DSCNQVSIST IPTTSTAQPE 180
  181 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [367-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLFNVTDSQT VEQWLPTEVV PNDVFPTSNY AYIGMQNDSL QAVVSNGQID YDHSYQSTGQ  60
   61 TPLSPLIIGS SGRQQQTQTS PGSVTVTATA TQSLFDPYHS QRHSFSDCTT DSSSTCSRLS 120
  121 SESPRYTSES STGTHESRFY GKLAPSSGSR YQRSSSPRSS QSSIKIARVV PL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [539-623]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASGQRKRGRQ SKDEQLASDN ELPVSAFQIS EMSLSELQQV LKNESLSEYQ RQLIRKIRRR  60
   61 GKNKVAARTC RQRRTDRHDK MSHYI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.69897
Match: 1sknP
Description: Skn-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.56528092116191 bayes_pls_golite062009
DNA binding 4.39236205038451 bayes_pls_golite062009
nucleic acid binding 4.27517034548789 bayes_pls_golite062009
transcription factor activity 3.86034396858961 bayes_pls_golite062009
binding 3.28937567198027 bayes_pls_golite062009
protein binding 2.82801305666365 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.80824533696213 bayes_pls_golite062009
transcription activator activity 2.80670414213103 bayes_pls_golite062009
protein heterodimerization activity 1.87549895714075 bayes_pls_golite062009
protein dimerization activity 1.4553301455216 bayes_pls_golite062009
sequence-specific DNA binding 1.12585390480455 bayes_pls_golite062009
transcription factor binding 0.495155180229128 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle