Protein Overview: daf-2

General Information:
Name(s) found:	daf-2 / CE27499 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00000898 locus:daf-2 status:Confirmed UniProt:Q968Y9 protein_id:CCD72201.1 [WormBase] gi\|71995160\|ref\|NP_497650.3\| abnormal DAuer Formation family member (daf-2) [Caenorhabditis elegans] [NCBI NR] gi\|13786530\|gb\|AAK29947.2\| Abnormal dauer formation protein 2, isoform a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] [wormpep67.fasta] Abnormal dauer formation protein 2 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas] CE27499 WBGene00000898 locus:daf-2 status:Confirmed TR:Q968Y9 protein_id:AAK29947.2 [wormpep150.fasta] 27499 WBGene00000898 locus:daf-2 status:Confirmed TR:Q968Y9 protein_id:AAK29947.2 [wormpep130-phg-ecoli-orf-rand.fasta] locus:daf-2 status:Confirmed TR:Q968Y9 protein_id:AAK29947.2 [wormpep115.fasta.reversed] CE27499 locus:daf-2 status:Confirmed [wormpep80.hongbin] CE27499 WBGene00000898 locus:daf-2 status:Confirmed [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE27499 WBGene00000898 locus:daf-2 status:Confirmed\| [wormORF-contam.fasta] abnormal DAuer Formation family member (daf-2) [Caenorhabditis elegans] [nr-271106-contam.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE27499 WBGene00000898 locus:daf-2 status:Confirmed UniProt:Q968Y9 protein_id:AAK29947.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta] CE27499 WBGene00000898 locus:daf-2 status:Confirmed UniProt:Q968Y9_CAEEL protein_id:AAK29947.2 [wormbase_c-elegans_197_11-26-2008_reversed.fasta]
Organism:	Caenorhabditis elegans
Length:	1843 amino acids
Gene Ontology:
Cellular Component:	integral to plasma membrane [ISS] cytoplasm [IEA] membrane [IEA]
Biological Process:	peptidyl-tyrosine phosphorylation [ISS] dauer larval development [IMP ] insulin receptor signaling pathway [ISS] signal transduction [IEA] determination of adult lifespan [IMP ] protein amino acid autophosphorylation [ISS] negative regulation of transcription factor import into nucleus [IGI] protein amino acid phosphorylation [IEA] reproduction [IMP] learning or memory [IMP] locomotory behavior [IMP] dauer exit [IMP] regulation of lipid metabolic process [IMP] regulation of chemotaxis [IMP]
Molecular Function:	ATP binding [IEA][ISS] protein tyrosine kinase activity [IEA] insulin receptor activity [ISS] non-membrane spanning protein tyrosine kinase activity [IEA] peptide hormone binding [ISS] protein kinase activity [IEA] SH2 domain binding [ISS] protein serine/threonine kinase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIVRCRRRH KILENLEEEN LGPSCSSTTS TTAATEALGT TTEDMRLKQQ RSSSRATEHD  60
   61 IVDGNHHDDE HITMRRLRLV KNSRTRRRTT PDSSMDCYEE NPPSQKTSIN YSWISKKSSM 120
  121 TSLMLLLLFA FVQPCASIVE KRCGPIDIRN RPWDIKPQWS KLGDPNEKDL AGQRMVNCTV 180
  181 VEGSLTISFV LKHKTKAQEE MHRSLQPRYS QDEFITFPHL REITGTLLVF ETEGLVDLRK 240
  241 IFPNLRVIGG RSLIQHYALI IYRNPDLEIG LDKLSVIRNG GVRIIDNRKL CYTKTIDWKH 300
  301 LITSSINDVV VDNAAEYAVT ETGLMCPRGA CEEDKGESKC HYLEEKNQEQ GVERVQSCWS 360
  361 NTTCQKSCAY DRLLPTKEIG PGCDANGDRC HDQCVGGCER VNDATACHAC KNVYHKGKCI 420
  421 EKCDAHLYLL LQRRCVTREQ CLQLNPVLSN KTVPIKATAG LCSDKCPDGY QINPDDHREC 480
  481 RKCVGKCEIV CEINHVIDTF PKAQAIRLCN IIDGNLTIEI RGKQDSGMAS ELKDIFANIH 540
  541 TITGYLLVRQ SSPFISLNMF RNLRRIEAKS LFRNLYAITV FENPNLKKLF DSTTDLTLDR 600
  601 GTVSIANNKM LCFKYIKQLM SKLNIPLDPI DQSEGTNGEK AICEDMAINV SITAVNADSV 660
  661 FFSWPSFNIT DIDQRKFLGY ELFFKEVPRI DENMTIEEDR SACVDSWQSV FKQYYETSNG 720
  721 EPTPDIFMDI GPRERIRPNT LYAYYVATQM VLHAGAKNGV SKIGFVRTSY YTPDPPTLAL 780
  781 AQVDSDAIHI TWEAPLQPNG DLTHYTIMWR ENEVSPYEEA EKFCTDASTP ANRQHTKDPK 840
  841 ETIVADKPVD IPSSRTVAPT LLTMMGHEDQ QKTCAATPGC CSCSAIEESS EQNKKKRPDP 900
  901 MSAIESSAFE NKLLDEVLMP RDTMRVRRSI EDANRVSEEL EKAENLGKAP KTLGGKKPLI 960
  961 HISKKKPSSS STTSTPAPTI ASMYALTRKP TTVPGTRIRL YEIYEPLPGS WAINVSALAL1020
 1021 DNSYVIRNLK HYTLYAISLS ACQNMTVPGA SCSISHRAGA LKRTKHITDI DKVLNETIEW1080
 1081 RFMNNSQQVN VTWDPPTEVN GGIFGYVVKL KSKVDGSIVM TRCVGAKRGY STRNQGVLFQ1140
 1141 NLADGRYFVS VTATSVHGAG PEAESSDPIV VMTPGFFTVE IILGMLLVFL ILMSIAGCII1200
 1201 YYYIQVRYGK KVKALSDFMQ LNPEYCVDNK YNADDWELRQ DDVVLGQQCG EGSFGKVYLG1260
 1261 TGNNVVSLMG DRFGPCAIKI NVDDPASTEN LNYLMEANIM KNFKTNFIVK LYGVISTVQP1320
 1321 AMVVMEMMDL GNLRDYLRSK REDEVFNETD CNFFDIIPRD KFHEWAAQIC DGMAYLESLK1380
 1381 FCHRDLAARN CMINRDETVK IGDFGMARDL FYHDYYKPSG KRMMPVRWMS PESLKDGKFD1440
 1441 SKSDVWSFGV VLYEMVTLGA QPYIGLSNDE VLNYIGMARK VIKKPECCEN YWYKVMKMCW1500
 1501 RYSPRDRPTF LQLVHLLAAE ASPEFRDLSF VLTDNQMILD DSEALDLDDI DDTDMNDQVV1560
 1561 EVAPDVENVE VQSDSERRNT DSIPLKQFKT IPPINATTSH STISIDETPM KAKQREGSLD1620
 1621 EEYALMNHSG GPSDAEVRTY AGDGDYVERD VRENDVPTRR NTGASTSSYT GGGPYCLTNR1680
 1681 GGSNERGAGF GEAVRLTDGV GSGHLNDDDY VEKEISSMDT RRSTGASSSS YGVPQTNWSG1740
 1741 NRGATYYTSK AQQAATAAAA AAAALQQQQN GGRGDRLTQL PGTGHLQSTR GGQDGDYIET1800
 1801 EPKNYRNNGS PSRNGNSRDI FNGRSAFGEN EHLIEDNEHH PLV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: daf-2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: