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Protein Overview: daf-2

General Information:
Name(s) found: daf-2 / CE27499 [WormBase]
Description(s) found:
Found 15 descriptions.
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  • WBGene00000898 locus:daf-2 status:Confirmed UniProt:Q968Y9 protein_id:CCD72201.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 1843 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [ISSLink to PubMed article]
    cytoplasm [IEALink to PubMed article]
    membrane [IEALink to PubMed article]
    Biological Process: peptidyl-tyrosine phosphorylation [ISSLink to PubMed article]
    dauer larval development [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    insulin receptor signaling pathway [ISSLink to PubMed article]
    signal transduction [IEALink to PubMed article]
    determination of adult lifespan [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    protein amino acid autophosphorylation [ISSLink to PubMed article]
    negative regulation of transcription factor import into nucleus [IGILink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    learning or memory [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    dauer exit [IMPLink to PubMed article]
    regulation of lipid metabolic process [IMPLink to PubMed article]
    regulation of chemotaxis [IMPLink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article][ISSLink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    insulin receptor activity [ISSLink to PubMed article]
    non-membrane spanning protein tyrosine kinase activity [IEALink to PubMed article]
    peptide hormone binding [ISSLink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    SH2 domain binding [ISSLink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIVRCRRRH KILENLEEEN LGPSCSSTTS TTAATEALGT TTEDMRLKQQ RSSSRATEHD  60
   61 IVDGNHHDDE HITMRRLRLV KNSRTRRRTT PDSSMDCYEE NPPSQKTSIN YSWISKKSSM 120
  121 TSLMLLLLFA FVQPCASIVE KRCGPIDIRN RPWDIKPQWS KLGDPNEKDL AGQRMVNCTV 180
  181 VEGSLTISFV LKHKTKAQEE MHRSLQPRYS QDEFITFPHL REITGTLLVF ETEGLVDLRK 240
  241 IFPNLRVIGG RSLIQHYALI IYRNPDLEIG LDKLSVIRNG GVRIIDNRKL CYTKTIDWKH 300
  301 LITSSINDVV VDNAAEYAVT ETGLMCPRGA CEEDKGESKC HYLEEKNQEQ GVERVQSCWS 360
  361 NTTCQKSCAY DRLLPTKEIG PGCDANGDRC HDQCVGGCER VNDATACHAC KNVYHKGKCI 420
  421 EKCDAHLYLL LQRRCVTREQ CLQLNPVLSN KTVPIKATAG LCSDKCPDGY QINPDDHREC 480
  481 RKCVGKCEIV CEINHVIDTF PKAQAIRLCN IIDGNLTIEI RGKQDSGMAS ELKDIFANIH 540
  541 TITGYLLVRQ SSPFISLNMF RNLRRIEAKS LFRNLYAITV FENPNLKKLF DSTTDLTLDR 600
  601 GTVSIANNKM LCFKYIKQLM SKLNIPLDPI DQSEGTNGEK AICEDMAINV SITAVNADSV 660
  661 FFSWPSFNIT DIDQRKFLGY ELFFKEVPRI DENMTIEEDR SACVDSWQSV FKQYYETSNG 720
  721 EPTPDIFMDI GPRERIRPNT LYAYYVATQM VLHAGAKNGV SKIGFVRTSY YTPDPPTLAL 780
  781 AQVDSDAIHI TWEAPLQPNG DLTHYTIMWR ENEVSPYEEA EKFCTDASTP ANRQHTKDPK 840
  841 ETIVADKPVD IPSSRTVAPT LLTMMGHEDQ QKTCAATPGC CSCSAIEESS EQNKKKRPDP 900
  901 MSAIESSAFE NKLLDEVLMP RDTMRVRRSI EDANRVSEEL EKAENLGKAP KTLGGKKPLI 960
  961 HISKKKPSSS STTSTPAPTI ASMYALTRKP TTVPGTRIRL YEIYEPLPGS WAINVSALAL1020
 1021 DNSYVIRNLK HYTLYAISLS ACQNMTVPGA SCSISHRAGA LKRTKHITDI DKVLNETIEW1080
 1081 RFMNNSQQVN VTWDPPTEVN GGIFGYVVKL KSKVDGSIVM TRCVGAKRGY STRNQGVLFQ1140
 1141 NLADGRYFVS VTATSVHGAG PEAESSDPIV VMTPGFFTVE IILGMLLVFL ILMSIAGCII1200
 1201 YYYIQVRYGK KVKALSDFMQ LNPEYCVDNK YNADDWELRQ DDVVLGQQCG EGSFGKVYLG1260
 1261 TGNNVVSLMG DRFGPCAIKI NVDDPASTEN LNYLMEANIM KNFKTNFIVK LYGVISTVQP1320
 1321 AMVVMEMMDL GNLRDYLRSK REDEVFNETD CNFFDIIPRD KFHEWAAQIC DGMAYLESLK1380
 1381 FCHRDLAARN CMINRDETVK IGDFGMARDL FYHDYYKPSG KRMMPVRWMS PESLKDGKFD1440
 1441 SKSDVWSFGV VLYEMVTLGA QPYIGLSNDE VLNYIGMARK VIKKPECCEN YWYKVMKMCW1500
 1501 RYSPRDRPTF LQLVHLLAAE ASPEFRDLSF VLTDNQMILD DSEALDLDDI DDTDMNDQVV1560
 1561 EVAPDVENVE VQSDSERRNT DSIPLKQFKT IPPINATTSH STISIDETPM KAKQREGSLD1620
 1621 EEYALMNHSG GPSDAEVRTY AGDGDYVERD VRENDVPTRR NTGASTSSYT GGGPYCLTNR1680
 1681 GGSNERGAGF GEAVRLTDGV GSGHLNDDDY VEKEISSMDT RRSTGASSSS YGVPQTNWSG1740
 1741 NRGATYYTSK AQQAATAAAA AAAALQQQQN GGRGDRLTQL PGTGHLQSTR GGQDGDYIET1800
 1801 EPKNYRNNGS PSRNGNSRDI FNGRSAFGEN EHLIEDNEHH PLV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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