Protein Overview: par-4

General Information:
Name(s) found:	par-4 / CE27410 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00003919 locus:par-4 Serine\/threonine-protein kinase par-4 status:Confirmed UniProt:Q9GN62 protein_id:CAC14418.2 [WormBase] gi\|5566277\|gb\|AAD45355.1\|AF160189_1 putative serine-threonine kinase PAR-4 [Caenorhabditis elegans] [NCBI NR] gi\|17566086\|ref\|NP_507533.1\| abnormal embryonic PARtitioning of cytoplasm family member (par-4) [Caenorhabditis elegans] [NCBI NR] gi\|14530656\|emb\|CAC14418.2\| C. elegans protein Y59A8B.14, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|14530629\|emb\|CAC15862.2\| C. elegans protein Y59A8B.14, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] Serine/threonine-protein kinase par-4 OS=Caenorhabditis elegans GN=par-4 PE=1 SV=2 [Swiss-Prot] [wormpep67.fasta] CE27410 WBGene00003919 locus:par-4 serine-threonine protein kinase status:Confirmed TR:Q9GN62 protein_id:CAC14418.2 [wormpep150.fasta] 27410 WBGene00003919 locus:par-4 serine-threonine protein kinase status:Confirmed TR:Q9GN62 protein_id:CAC14418.2 [wormpep130-phg-ecoli-orf-rand.fasta] putative serine-threonine kinase cortically distributed in early embryos and required for establishing embryonic asymmetry., abnormal embryonic PARtitioning of cytoplasm PAR-4 (69.6 kD) (par-4) [Caenorhabditis elegans]gi\|14530656\|emb\|CAC14418.2\| Hypothet [nrdb_11152004_Chlamydomonas] locus:par-4 serine-threonine protein kinase status:Confirmed TR:Q9GN62 protein_id:CAC14418.2 [wormpep115.fasta.reversed] CE27410 locus:par-4 serine-threonine protein kinase status:Confirmed TR:Q9GN62 protein_id:CAC14418.2 [wormpep80.hongbin] CE27410 WBGene00003919 locus:par-4 serine-threonine protein kinase status:Confirmed UniProt:Q9GN62_CAEEL protein_id:CAC15862.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE27410 WBGene00003919 locus:par-4 serine-threonine protein kinase status:Confirmed UniProt:Q9GN62_CAEEL protein_id:CAC15862.2\| [wormORF-contam.fasta] putative serine-threonine kinase PAR-4 [Caenorhabditis elegans] [nr-271106-contam.fasta] abnormal embryonic PARtitioning of cytoplasm family member (par-4) [Caenorhabditis elegans] [nr-271106-contam.fasta] Hypothetical protein Y59A8B.14 [Caenorhabditis elegans] [nr-271106-contam.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE27410 WBGene00003919 locus:par-4 serine-threonine protein kinase status:Confirmed UniProt:Q9GN62 protein_id:CAC15862.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta] CE27410 WBGene00003919 locus:par-4 serine-threonine protein kinase status:Confirmed UniProt:Q9GN62 protein_id:CAC14418.2 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta] CE27410 WBGene00003919 locus:par-4 status:Confirmed UniProt:Q9GN62 protein_id:CAC14418.2 Serine\/threonine-protein kinase par-4 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	617 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA] cell cortex [IDA]
Biological Process:	asymmetric protein localization involved in cell fate determination [IMP] cell differentiation [IMP] establishment of cell polarity [IMP] asymmetric cell division [IMP] protein amino acid phosphorylation [IEA]
Molecular Function:	magnesium ion binding [IEA] ATP binding [IEA] protein tyrosine kinase activity [IEA] zinc ion binding [IEA] protein kinase activity [IEA] protein serine/threonine kinase activity [IEA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAPSTSSGA QSKLLMPGDD EADEDHQNRG DPNLQQKQKI QLNVDPDYDD DEDDDCFIDG  60
   61 CEASAPITRE LVDGAIERRS KDRNVKMSIG VYDEYDDDDD DEEETEEDQR RRFVEGIRNI 120
  121 RHKQQESFDL EEHPIPVESE AMRQFINQQV NNAMMFNQDN SEFQHIEFEP IVKQKGPKII 180
  181 EGYMWGGQIG TGSYGKVKEC IDMYTLTRRA VKIMKYDKLR KITNGWENIR SEMSILRRMN 240
  241 HRNVIKLIEI FNIPAKGKVY MVFEYCIGSV QQLLDMEPAR RLTIGESHAI FIELCQGLNY 300
  301 LHSKRVSHKD IKPGNLLVSI DFTVKICDFG VAEQINLFQR DGRCTKVNGT PKFQPPECIY 360
  361 GNHDFFDGYK ADMWSAGVTL YNLVSGKYPF EKPVLLKLYE CIGTEPLQMP TNVQLTKDLQ 420
  421 DLLTKLLEKD FNERPTCLET MIHPWFLSTF PEDQGLGRIM ERMRTGDRPL TMLSSMTALY 480
  481 DGITPEDELI IEDNLGIIQQ ILPINLTSEA VLERGSFPGF KFLEAKPGDG PDGVEGSEDS 540
  541 AAPLGPQRRP SSRSMPTCAP PGPAAGNAQN STAENGAETD GVASASDPPP TAAPGAPPRR 600
  601 RKRNFFSCIF RSRTDSA

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.24008660655062	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	4.93501454706421	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.63692708178478	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.26787750561728	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
tubulin binding	2.18641675163967	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
microtubule binding	1.88110801192607	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
telethonin binding	1.59285057739948	bayes_pls_golite062009
protein tyrosine kinase activity	1.3898059094397	bayes_pls_golite062009
actin binding	1.33479685165255	bayes_pls_golite062009
protein binding	1.22565748038754	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.20800936400261	bayes_pls_golite062009
molecular adaptor activity	1.17345244671832	bayes_pls_golite062009
receptor signaling protein activity	1.13658159660305	bayes_pls_golite062009
SH3/SH2 adaptor activity	1.08185110129009	bayes_pls_golite062009
protein binding, bridging	0.83823250804321	bayes_pls_golite062009
alpha-actinin binding	0.713064190387634	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
transporter activity	0.553953601841147	bayes_pls_golite062009
cyclin-dependent protein kinase activity	0.499492353295369	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
transmembrane transporter activity	0.37676337669549	bayes_pls_golite062009
signal transducer activity	0.270054246024761	bayes_pls_golite062009
molecular transducer activity	0.270054246024761	bayes_pls_golite062009
actin filament binding	0.2403700250846	bayes_pls_golite062009
MAP kinase activity	0.08504542461349	bayes_pls_golite062009
substrate-specific transporter activity	0.0611721261859464	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.0556163711947139	bayes_pls_golite062009
transmembrane receptor activity	0.00652065412910241	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..514]	PSI-BLAST	59.09691	CHICKEN SRC TYROSINE KINASE
2	View Details	[515..617]	deduced	N/A	No confident structure predictions are available.

Protein Overview: par-4

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: