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Protein Overview: par-4

General Information:
Name(s) found: par-4 / CE27410 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00003919 locus:par-4 Serine\/threonine-protein kinase par-4 status:Confirmed UniProt:Q9GN62 protein_id:CAC14418.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 617 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    cell cortex [IDALink to PubMed article]
    Biological Process: asymmetric protein localization involved in cell fate determination [IMPLink to PubMed article]
    cell differentiation [IMPLink to PubMed article]
    establishment of cell polarity [IMPLink to PubMed article]
    asymmetric cell division [IMPLink to PubMed article]
    protein amino acid phosphorylation [IEALink to PubMed article]
    Molecular Function: magnesium ion binding [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein tyrosine kinase activity [IEALink to PubMed article]
    zinc ion binding [IEALink to PubMed article]
    protein kinase activity [IEALink to PubMed article]
    protein serine/threonine kinase activity [IEALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAPSTSSGA QSKLLMPGDD EADEDHQNRG DPNLQQKQKI QLNVDPDYDD DEDDDCFIDG  60
   61 CEASAPITRE LVDGAIERRS KDRNVKMSIG VYDEYDDDDD DEEETEEDQR RRFVEGIRNI 120
  121 RHKQQESFDL EEHPIPVESE AMRQFINQQV NNAMMFNQDN SEFQHIEFEP IVKQKGPKII 180
  181 EGYMWGGQIG TGSYGKVKEC IDMYTLTRRA VKIMKYDKLR KITNGWENIR SEMSILRRMN 240
  241 HRNVIKLIEI FNIPAKGKVY MVFEYCIGSV QQLLDMEPAR RLTIGESHAI FIELCQGLNY 300
  301 LHSKRVSHKD IKPGNLLVSI DFTVKICDFG VAEQINLFQR DGRCTKVNGT PKFQPPECIY 360
  361 GNHDFFDGYK ADMWSAGVTL YNLVSGKYPF EKPVLLKLYE CIGTEPLQMP TNVQLTKDLQ 420
  421 DLLTKLLEKD FNERPTCLET MIHPWFLSTF PEDQGLGRIM ERMRTGDRPL TMLSSMTALY 480
  481 DGITPEDELI IEDNLGIIQQ ILPINLTSEA VLERGSFPGF KFLEAKPGDG PDGVEGSEDS 540
  541 AAPLGPQRRP SSRSMPTCAP PGPAAGNAQN STAENGAETD GVASASDPPP TAAPGAPPRR 600
  601 RKRNFFSCIF RSRTDSA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..514] PSI-BLAST 59.09691 CHICKEN SRC TYROSINE KINASE
    2 View Details [515..617] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.24008660655062 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  4.93501454706421 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63692708178478 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.26787750561728 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • tubulin binding
    		•  2.18641675163967 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.12615078788254 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • microtubule binding
    		•  1.88110801192607 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • telethonin binding
    		•  1.59285057739948 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • actin binding
    		•  1.33479685165255 bayes_pls_golite062009
  • protein binding
    		•  1.22565748038754 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.20800936400261 bayes_pls_golite062009
  • molecular adaptor activity
    		•  1.17345244671832 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.13658159660305 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  1.08185110129009 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.83823250804321 bayes_pls_golite062009
  • alpha-actinin binding
    		•  0.713064190387634 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.612883428421652 bayes_pls_golite062009
  • transporter activity
    		•  0.553953601841147 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  0.499492353295369 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.37676337669549 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • actin filament binding
    		•  0.2403700250846 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.08504542461349 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0611721261859464 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle