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Protein Overview: mab-5

General Information:
Name(s) found: mab-5 / CE25765 [WormBase]
Description(s) found:
Found 21 descriptions.
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  • WBGene00003102 locus:mab-5 Homeobox protein mab-5 status:Confirmed UniProt:P10038 protein_id:CCD63641.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 200 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][IEALink to PubMed article]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article]
    regulation of cell fate specification [IMPLink to PubMed article]
    localization [IMPLink to PubMed article]
    anterior/posterior pattern formation [IGILink to PubMed article][IMPLink to PubMed article]
    tail tip morphogenesis [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    regulation of cell migration [IMPLink to PubMed article]
    positive regulation of epithelial cell proliferation [IMPLink to PubMed article]
    Molecular Function: DNA binding [IEALink to PubMed article]
    transcription factor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSMYPGWTGD DSYWAGAGTT ASSQSASSGT SASASSSAAA AAAANNLKTY ELYNHTYMNN  60
   61 MKHMLAAGWM DNSSNPFAYN PLQATSANFG ETRTSMPAIS QPVFPWMKMG GAKGGESKRT 120
  121 RQTYSRSQTL ELEKEFHYHK YLTRKRRQEI SETLHLTERQ VKIWFQNRRM KHKKEAKGEG 180
  181 GSNESDEESN QDEQNEQHSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..117] MSA 5.243997 View MSA. No confident structure predictions are available.
    2 View Details [118..200] PSI-BLAST 27.69897 DETERMINATION OF THE THREE-DIMENSIONAL STRUCTURE OF THE ANTENNAPEDIA HOMEODOMAIN FROM DROSOPHILA IN SOLUTION BY 1H NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  3.57523737355937 bayes_pls_golite062009
  • DNA binding
    		•  3.00143272905695 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.89825020286436 bayes_pls_golite062009
  • transcription factor activity
    		•  2.53664874743748 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.84054423341798 bayes_pls_golite062009
  • binding
    		•  1.68817361068715 bayes_pls_golite062009
  • protein binding
    		•  1.16239587634422 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.14821760889085 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.46503550280898 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle