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Protein Overview: mex-3

General Information:
Name(s) found: mex-3 / CE25000 [WormBase]
Description(s) found:
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  • WBGene00003229 locus:mex-3 status:Confirmed UniProt:Q95R07 protein_id:CCD71703.1 [WormBase]
  • gi|71986863|ref|NP_001021489.1| Muscle EXcess family member (mex-3) [Caenorhabditis elegans] [NCBI NR]
  • ref|NP_490681.1| KH domain protein, embryonic cell fate determinant, Muscle EXcess MEX-3 (45.4 kD) (mex-3) [Caenorhabditis elegans] [NCBI NR]
  • gi|14916306|gb|AAK73872.1|AF003139_6 Muscle excess protein 3, isoform a [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE25000 WBGene00003229 locus:mex-3 status:Confirmed TR:Q95R07 protein_id:AAK73872.1 [wormpep150.fasta]
  • 25000 WBGene00003229 locus:mex-3 status:Confirmed TR:Q95R07 protein_id:AAK73872.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • KH domain protein, embryonic cell fate determinant, Muscle EXcess MEX-3 (45.4 kD) (mex-3) [Caenorhabditis elegans]gi|14916306|gb|AAK73872.1| Muscle excess protein 3, isoform a [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • locus:mex-3 status:Confirmed TR:Q95R07 protein_id:AAK73872.1 [wormpep115.fasta.reversed]
  • CE25000 status:Confirmed TR:Q95R07 protein_id:AAK73872.1 [wormpep80.hongbin]
  • CE25000 WBGene00003229 locus:mex-3 status:Confirmed UniProt:Q95R07_CAEEL protein_id:AAK73872.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE25000 WBGene00003229 locus:mex-3 status:Confirmed UniProt:Q95R07_CAEEL protein_id:AAK73872.1| [wormORF-contam.fasta]
  • Muscle excess protein 3, isoform a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Muscle EXcess family member (mex-3) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE25000 WBGene00003229 locus:mex-3 status:Confirmed UniProt:Q95R07 protein_id:AAK73872.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE25000 WBGene00003229 locus:mex-3 status:Confirmed UniProt:Q95R07 protein_id:CCD71703.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • Isoform of H2L067, Muscle EXcess OS=Caenorhabditis elegans GN=mex-3 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 415 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    P granule [IDALink to PubMed article]
    Biological Process: negative regulation of muscle cell differentiation [IGILink to PubMed article][IMPLink to PubMed article]
    embryonic pattern specification [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    gastrulation with mouth forming first [IMPLink to PubMed article]
    cell fate specification [IMPLink to PubMed article]
    organelle inheritance [IMPLink to PubMed article]
    Molecular Function: RNA binding [IEALink to PubMed article]
    single-stranded RNA binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKEEQIAYKL PGAWYYEEDT ASCSPVSDPE DIAQFLNYRT SIGVQNVTES VEVPTSEHVA  60
   61 EIVGRQGCKI KALRAKTNTY IKTPVRGEDP IFVVTGRLED VNEAKREIDC AAEHFTQIRA 120
  121 SRRHTQVVPG AHAPGQITSY VRVPLRVVGL VVGPKGATIK RIQQDTHTYI ITPSREREPV 180
  181 FEVTGLPHNV EAARKEIETH IFQRTGNLPE TDNDFAGQLA GVSLMVQKQQ QAQQQMQEAQ 240
  241 QQSMFYRRAF GNSNPFNQKE MSSSPFGMES SLGLDALLRS FPSMRSSLTP ESLSGTGLSS 300
  301 RPSLGGGQSA KQDLPTYDYW GTNNSLNDIM ENEILSRKYD ALSAWSSMGL EKREESPTNG 360
  361 LMSSLKGTSA GFGLLSTIWS GGNMNLSPGS LASASASPTS STCDHNDHTL VPING

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123] PSI-BLAST 9.221849 Solution structure of KH domain in FUSE binding protein 1
    2 View Details [124..206] PSI-BLAST 12.69897 No description for 2dgrA was found.
    3 View Details [207..415] MSA 2.389996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  2.76562424828414 bayes_pls_golite062009
  • binding
    		•  2.12000404411947 bayes_pls_golite062009
  • mRNA binding
    		•  1.67623463602459 bayes_pls_golite062009
  • RNA binding
    		•  1.5640739272938 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.573444640703857 bayes_pls_golite062009
  • catalytic activity
    		•  0.483552478758071 bayes_pls_golite062009
  • protein binding
    		•  0.446932489882167 bayes_pls_golite062009
  • DNA binding
    		•  0.219740042471452 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0918327634805927 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle