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Protein Overview: mec-12

General Information:
Name(s) found: mec-12 / CE24843 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00003175 locus:mec-12 Tubulin alpha-3 chain status:Confirmed UniProt:P91910 protein_id:CCD67209.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 450 amino acids

    Gene Ontology:
    Cellular Component: protein complex [IEALink to PubMed article]
    microtubule [IDALink to PubMed article][IEALink to PubMed article]
    Biological Process: mechanosensory behavior [IMPLink to PubMed article]
    protein polymerization [IEALink to PubMed article]
    microtubule-based process [IEALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]
    response to mechanical stimulus [IMPLink to PubMed article]
    Molecular Function: GTP binding [IEALink to PubMed article]
    GTPase activity [IEALink to PubMed article]
    structural constituent of cytoskeleton [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MREVISIHIG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK SLGGSDDSFS TFFSETGSGR  60
   61 HVPRAVMVDL EPTVIDEIRT GTYRSLFHPE QLITGKEDAA NNYARGHYTI GKEIIDLTLD 120
  121 RIRRLADNCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKAKLEFS IYPAPQVSTA 180
  181 VVEPYNSILT THTTLEHSDC SFMVDNEAIY DICRRNLDIE RPSYTNLNRL IGQIVSSITA 240
  241 SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TFSPVISAEK AYHEQLSVAE ITNMCFEPHN 300
  301 QMVKCDPRHG KYMAVCLLFR GDVVPKDVNA AIATIKTKRS IQFVDWCPTG FKVGINYQPP 360
  361 TVVPGGDLAK VPRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE 420
  421 AREDLAALEK DYEEVGVDSM EDNGEEGDEY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..450] PSI-BLAST 175.0 Tubulin-colchicine-vinblastine: stathmin-like domain complex

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • structural constituent of cytoskeleton
    		•  4.04224160177678 bayes_pls_golite062009
  • structural molecule activity
    		•  3.32779015200848 bayes_pls_golite062009
  • tubulin binding
    		•  2.4432045213385 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.24606230377981 bayes_pls_golite062009
  • binding
    		•  2.00508289492248 bayes_pls_golite062009
  • GTPase activity
    		•  1.87512665946067 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.77500173070686 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.7017047947554 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.68267378160702 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.68038087466376 bayes_pls_golite062009
  • protein binding
    		•  1.60795853516357 bayes_pls_golite062009
  • MHC class I protein binding
    		•  1.46574865275013 bayes_pls_golite062009
  • gamma-tubulin binding
    		•  1.02742779831447 bayes_pls_golite062009
  • hydrolase activity
    		•  0.502038132260603 bayes_pls_golite062009
  • receptor binding
    		•  0.00945891657658993 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.80

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle