Protein Overview: mbk-2

General Information:
Name(s) found:	mbk-2 / CE23751 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00003150 locus:mbk-2 Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 status:Confirmed UniProt:Q9XTF3 protein_id:CAB54254.2 [WormBase] gi\|71989001\|ref\|NP_001023208.1\| MiniBrain Kinase (Drosophila) homolog family member (mbk-2) [Caenorhabditis elegans] [NCBI NR] gi\|6425202\|emb\|CAB54308.2\| C. elegans protein F49E11.1c, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|6425195\|emb\|CAB54274.2\| C. elegans protein F49E11.1c, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|6425192\|emb\|CAB54254.2\| C. elegans protein F49E11.1c, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|20135608\|gb\|AAM09088.1\| minibrain kinase 2 [Caenorhabditis elegans] [NCBI NR] ref\|NP_502492.1\| MiniBrain Kinase homolog, dual-specificity serine/threonine tyrosine-phosphorylation regulated kinase, DYRK homolog., MiniBrain Kinase homolog MBK-2 (87.4 kD) (mbk-2) [Caenorhabditis elegans] [NCBI NR] [wormpep67.fasta] CE23751 WBGene00003150 locus:mbk-2 status:Confirmed TR:Q9TVF4 protein_id:CAB54308.2 [wormpep150.fasta] 23751 WBGene00003150 locus:mbk-2 status:Confirmed TR:Q9TVF4 protein_id:CAB54308.2 [wormpep130-phg-ecoli-orf-rand.fasta] MiniBrain Kinase homolog, dual-specificity serine/threonine tyrosine-phosphorylation regulated kinase, DYRK homolog., MiniBrain Kinase homolog MBK-2 (87.4 kD) (mbk-2) [Caenorhabditis elegans]gi\|20135608\|gb\|AAM09088.1\| minibrain kinase 2 [Caenorhabditis e [nrdb_11152004_Chlamydomonas] locus:mbk-2 status:Confirmed TR:Q9TVF4 protein_id:CAB54308.2 [wormpep115.fasta.reversed] CE23751 status:Confirmed TR:Q9TVF4 protein_id:CAB54308.2 [wormpep80.hongbin] CE23751 WBGene00003150 locus:mbk-2 status:Confirmed UniProt:Q9TVF4_CAEEL protein_id:CAB54308.2 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE23751 WBGene00003150 locus:mbk-2 status:Confirmed UniProt:Q9TVF4_CAEEL protein_id:CAB54308.2\| [wormORF-contam.fasta] Hypothetical protein F49E11.1c [Caenorhabditis elegans] [nr-271106-contam.fasta] MiniBrain Kinase (Drosophila) homolog family member (mbk-2) [Caenorhabditis elegans] [nr-271106-contam.fasta] minibrain kinase 2 [Caenorhabditis elegans] [nr-271106-contam.fasta] CE23751 WBGene00003150 locus:mbk-2 status:Confirmed UniProt:Q9TVF4 protein_id:CAB54308.2 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE23751 WBGene00003150 locus:mbk-2 status:Confirmed UniProt:Q9XTF3 protein_id:CAB54254.2 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta] CE23751 WBGene00003150 locus:mbk-2 status:Confirmed UniProt:Q9XTF3 protein_id:CAB54254.2 Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 [wormpep246-ecoli-contam.fasta] Isoform of Q9XTF3, Isoform c of Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 OS=Caenorhabditis elegans GN=mbk-2 [CAEEL.fasta.20160308]
Organism:	Caenorhabditis elegans
Length:	796 amino acids
Gene Ontology:
Cellular Component:	centrosome [IDA] cytoplasm [IDA] cell cortex [IDA] P granule [IDA] chromosome [IDA]
Biological Process:	embryonic cleavage [IMP ] peptidyl-tyrosine phosphorylation [ISS] spindle organization [IMP] pronuclear migration [IMP ] embryonic development ending in birth or egg hatching [IMP ] embryonic pattern specification [IMP] protein amino acid autophosphorylation [ISS] positive regulation of protein catabolic process [IMP] cytokinesis [IMP ] gamete generation [IMP] protein amino acid phosphorylation [IEA] positive regulation of multicellular organism growth [IMP] microtubule-based process [IMP] establishment of mitotic spindle orientation [IMP ] asymmetric protein localization involved in cell fate determination [IMP] morphogenesis of an epithelium [IMP] cytokinesis after mitosis [IMP] peptidyl-serine phosphorylation [ISS] peptidyl-threonine phosphorylation [ISS]
Molecular Function:	ATP binding [IEA][ISS] protein tyrosine kinase activity [IEA][ISS] protein kinase activity [IEA] protein serine/threonine kinase activity [IEA][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAALASFTRN SRSYGQQPID VTQQGQRDRS VMSLDAQGRS VSHECPTSTT LVRQLYLPQI  60
   61 PQSASFAAAP TSFSGASSSS SNHHHPVYHS QNSLPPNLLG SSQNSASSNS LVQGHRNPAL 120
  121 GSGNTLTRSY HQPSSTNSST NNLYGPLGTI SRDLKQSIRD ISPPVINSSA NPHLVNYVQT 180
  181 SSFDNGSYEF PSGQAQQQRR LGGSQQHLAP LQQTASSLYS NPQSSSSQLL GQQQAVRPNY 240
  241 AYQQSLPRQQ HINSHQTQAF FGTVRGPTNS TNIVTPLRAS KTMIDVLAPV RDTVAAQATG 300
  301 LPNVGTSSSN GSSNSSSGVG SGGSGSLMTQ SIGGPNKHLS ASHSTLNTAS THDMMHSKIP 360
  361 KSPSNESLSR SHTSSSGGSQ GGHNSNSGSN SGFRPEDAVQ TFGAKLVPFE KNEIYNYTRV 420
  421 FFVGSHAKKQ AGVIGGANNG GYDDENGSYQ LVVHDHIAYR YEVLKVIGKG SFGQVIKAFD 480
  481 HKYQQYVALK LVRNEKRFHR QADEEIRILD HLRRQDSDGT HNIIHMLDYF NFRNHKCITF 540
  541 ELLSINLYEL IKRNKFQGFS LMLVRKFAYS MLLCLDLLQK NRLIHCDLKP ENVLLKQQGR 600
  601 SGIKVIDFGS SCFDDQRIYT YIQSRFYRAP EVILGTKYGM PIDMWSLGCI LAELLTGYPL 660
  661 LPGEDENDQL ALIIELLGMP PPKSLETAKR ARTFITSKGY PRYCTATSMP DGSVVLAGAR 720
  721 SKRGKMRGPP ASRSWSTALK NMGDELFVDF LKRCLDWDPE TRMTPAQALK HKWLRRRLPN 780
  781 PPRDGLESMG GLADHE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..150]	PSI-BLAST	9.0	pak1 autoregulatory domain
2	View Details	[151..333]	deduced	N/A	No confident structure predictions are available.
3	View Details	[334..721]	PSI-BLAST	42.09691	No description for 2ozoA was found.
4	View Details	[722..796]	PSI-BLAST	64.154902	Crystal structure of human CLK1 in complex with 10Z-Hymenialdisine

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: mbk-2

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: