Protein Overview: fre-1

General Information:
Name(s) found:	fre-1 / CE23279 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00001485 locus:fre-1 status:Confirmed UniProt:G5EGH9 protein_id:CAB60480.1 [WormBase] gi\|6425246\|emb\|CAB60480.1\| C. elegans protein Y113G7A.8, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|30138171\|gb\|AAL86012.1\| NADPH-dependent flavin reductase [Caenorhabditis elegans] [NCBI NR] gi\|17566446\|ref\|NP_507875.1\| Flavin REductase family member (fre-1) [Caenorhabditis elegans] [NCBI NR] [wormpep67.fasta] CE23279 WBGene00001485 locus:fre-1 status:Confirmed TR:Q9U2Y8 protein_id:CAB60480.1 [wormpep150.fasta] 23279 WBGene00001485 locus:fre-1 status:Confirmed TR:Q9U2Y8 protein_id:CAB60480.1 [wormpep130-phg-ecoli-orf-rand.fasta] flavodoxin family (66.4 kD) (5U546) [Caenorhabditis elegans]gi\|30138171\|gb\|AAL86012.1\| NADPH-dependent flavin reductase [Caenorhabditis elegans]gi\|6425246\|emb\|CAB60480.1\| Hypothetical protein Y113G7A.8 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas] locus:fre-1 status:Confirmed TR:Q9U2Y8 protein_id:CAB60480.1 [wormpep115.fasta.reversed] CE23279 status:Partially_confirmed TR:Q9U2Y8 protein_id:CAB60480.1 [wormpep80.hongbin] CE23279 WBGene00001485 locus:fre-1 status:Confirmed UniProt:Q9U2Y8_CAEEL protein_id:CAB60480.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE23279 WBGene00001485 locus:fre-1 status:Confirmed UniProt:Q9U2Y8_CAEEL protein_id:CAB60480.1\| [wormORF-contam.fasta] Flavin REductase family member (fre-1) [Caenorhabditis elegans] [nr-271106-contam.fasta] NADPH-dependent flavin reductase [Caenorhabditis elegans] [nr-271106-contam.fasta] Hypothetical protein Y113G7A.8 [Caenorhabditis elegans] [nr-271106-contam.fasta] CE23279 WBGene00001485 locus:fre-1 status:Confirmed UniProt:Q9U2Y8 protein_id:CAB60480.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE23279 WBGene00001485 locus:fre-1 status:Confirmed UniProt:G5EGH9 protein_id:CAB60480.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta] CE23279 WBGene00001485 locus:fre-1 status:Confirmed UniProt:G5EGH9 protein_id:CAB60480.1 NADPH-dependent diflavin oxidoreductase 1 [c_elegans-PRJNA13758-WS250-ecoli-contam.fasta] Isoform of M1ZMI3, NADPH-dependent diflavin oxidoreductase 1 OS=Caenorhabditis elegans GN=fre-1 PE=1 SV=1 [CAEEL.fasta.20160308]
Organism:	Caenorhabditis elegans
Length:	585 amino acids
Gene Ontology:
Cellular Component:	thylakoid membrane [IEA]
Biological Process:	electron transport [IEA]
Molecular Function:	NADP or NADPH binding [IEA] FMN binding [IEA] oxidoreductase activity [IEA] FAD binding [IEA] 2 iron, 2 sulfur cluster binding [IEA] ferredoxin-NADP+ reductase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIAILYGSE TGTAQDIAES LRREAQQRHL QARVHELDEY DVSQLPMEKV VLFVVSTTGQ  60
   61 GEMPPNMRKT WKLLLRKSLG ADFLKNVNIG VLGLGDSSYQ KYNFAGKKLY RRLVQLGAKM 120
  121 MCGVHLADDQ HEIGIDGAFI PWKTECWKKI KEIAENLSIY REMTAEIDTS VQITTKYRFL 180
  181 ELGGESGNDD DDSDEDLEPQ IEIPDYFPLK VLKNRRLTSA EHFQDTRLVD FEISDRNRSK 240
  241 MGFQPGDVLM VRPYNPEETV KIAIEALGLT EEQLKKPLKI VKNDRFSKNP PNFLVGTKTT 300
  301 LLTCLQRYFD LQQVPKRSFF EMLGYYSTNP PEKERLQELA SPEGLDDYLD YANRSRRTTA 360
  361 EALRDFVATS KNLKPDYLFE ILTTIRPRAF SIASAPSPFH LELLVAKVEY KSRMADKRRG 420
  421 LCSTFISRLK PGDEVFCKIR PGTFKFPSPE APVICIGPGT GVAPFRSLFG HRSLFSAHFP 480
  481 GILFFGCRSE HHDYYFSDEW PELSGVAVIP AFSRDTDGRK VYVQHKMGEN AGKIKRMLDL 540
  541 GAQVFIAGSS GDMPKAVSAV LAQIQGDEWT RRAEETGKIQ YETWS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
sulfite reductase (NADPH) activity	8.084406223553	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	4.30314846685644	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	4.19887641848781	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	4.06091555929351	bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity	3.8525097290463	bayes_pls_golite062009
arginine binding	3.31453699236145	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor	3.111558299994	bayes_pls_golite062009
NADH dehydrogenase activity	3.09973680094998	bayes_pls_golite062009
oxidoreductase activity	3.02740987944465	bayes_pls_golite062009
tetrahydrobiopterin binding	3.017442325411	bayes_pls_golite062009
NADH dehydrogenase (quinone) activity	3.01705400717654	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	2.84592668144284	bayes_pls_golite062009
FAD binding	2.07600122867642	bayes_pls_golite062009
transcription regulator activity	2.07119387257991	bayes_pls_golite062009
coenzyme binding	1.94345417147733	bayes_pls_golite062009
binding	1.76189957257133	bayes_pls_golite062009
nitric-oxide synthase activity	1.73361245661515	bayes_pls_golite062009
cytochrome-b5 reductase activity	1.5685421124725	bayes_pls_golite062009
ferredoxin-NADP+ reductase activity	1.46342400843015	bayes_pls_golite062009
ferredoxin reductase activity	1.46342400843015	bayes_pls_golite062009
oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	1.46342400843015	bayes_pls_golite062009
catalytic activity	1.45374095556065	bayes_pls_golite062009
phosphoric diester hydrolase activity	1.30413377266725	bayes_pls_golite062009
monooxygenase activity	1.24895114339483	bayes_pls_golite062009
NADP or NADPH binding	1.18833847639357	bayes_pls_golite062009
demethylase activity	1.1768217851058	bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	1.11231803143399	bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen	0.878188072733981	bayes_pls_golite062009
transferase activity	0.708491789248912	bayes_pls_golite062009
FMN binding	0.649158247260553	bayes_pls_golite062009
NAD(P)H oxidase activity	0.46219666758416	bayes_pls_golite062009
riboflavin synthase activity	0.380537461428523	bayes_pls_golite062009
protein binding	0.244726474314668	bayes_pls_golite062009
cofactor binding	0.205324283520452	bayes_pls_golite062009
transcription factor binding	0.065157440608373	bayes_pls_golite062009
cytoskeletal protein binding	0.0373671593900911	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.94

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..585]	PSI-BLAST	111.0	NADPH-cytochrome p450 reductase; NADPH-cytochrome p450 reductase, N-terminal domain

Protein Overview: fre-1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: