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Protein Overview: mys-1

General Information:
Name(s) found: mys-1 / CE21225 [WormBase]
Description(s) found:
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  • WBGene00007029 locus:mys-1 Histone acetyltransferase Tip60 homolog status:Confirmed UniProt:Q9TYU5 protein_id:CCD70078.1 [WormBase]
  • pir||T33814 hypothetical protein VC5.4 - Caenorhabditis elegans [NCBI NR]
  • gi|75024939|sp|Q9TYU5.1|TIP60_CAEEL RecName: Full=Histone acetyltransferase Tip60 homolog; AltName: Full=Myst family histone acetyltransferase-like protein 1 [NCBI NR]
  • gi|45451673|gb|AAS65427.1| histone acetyltransferase [Caenorhabditis elegans] [NCBI NR]
  • gi|3886064|gb|AAC78211.1| Myst family histone acetyltransferase-like protein 1 [Caenorhabditis elegans] [NCBI NR]
  • gi|17564938|ref|NP_504796.1| MYST family histone acetyltransferase-like family member (mys-1) [Caenorhabditis elegans] [NCBI NR]
  • Histone acetyltransferase Tip60 homolog OS=Caenorhabditis elegans GN=mys-1 PE=2 SV=1 [Swiss-Prot]
  • [wormpep67.fasta]
  • CE21225 WBGene00007029 locus:mys-1 status:Confirmed TR:Q9TYU5 protein_id:AAC78211.1 [wormpep150.fasta]
  • 21225 WBGene00007029 locus:mys-1 status:Confirmed TR:Q9TYU5 protein_id:AAC78211.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • tat interactive protein (5H562) [Caenorhabditis elegans]gi|3886064|gb|AAC78211.1| Myst family histone acetyltransferase-like protein 1 [Caenorhabditis elegans]gi|45451673|gb|AAS65427.1| histone acetyltransferase [Caenorhabditis elegans]gi|7508719|pir|| [nrdb_11152004_Chlamydomonas]
  • status:Partially_confirmed TR:Q9TYU5 protein_id:AAC78211.1 [wormpep115.fasta.reversed]
  • CE21225 status:Partially_confirmed TR:Q9TYU5 protein_id:AAC78211.1 [wormpep80.hongbin]
  • CE21225 WBGene00007029 locus:mys-1 status:Confirmed UniProt:TIP60_CAEEL protein_id:AAC78211.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE21225 WBGene00007029 locus:mys-1 status:Confirmed UniProt:TIP60_CAEEL protein_id:AAC78211.1| [wormORF-contam.fasta]
  • histone acetyltransferase [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • MYST family histone acetyltransferase-like family member (mys-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Histone acetyltransferase Tip60 homolog (Myst family histone acetyltransferase-like protein 1) [nr-271106-contam.fasta]
  • Myst family histone acetyltransferase-like protein 1 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE21225 WBGene00007029 locus:mys-1 status:Confirmed SW:Q9TYU5 protein_id:AAC78211.1 [WormBase_C-elegans_wp180_08-19-2007_reversed.fasta]
  • CE21225 WBGene00007029 locus:mys-1 status:Confirmed UniProt:Q9TYU5 protein_id:AAC78211.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE21225 WBGene00007029 locus:mys-1 status:Confirmed UniProt:Q9TYU5 protein_id:CCD70078.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE21225 WBGene00007029 locus:mys-1 status:Confirmed UniProt:Q9TYU5 protein_id:CCD70078.1 Histone acetyltransferase Tip60 homolog [wormpep246-ecoli-contam.fasta]
    • Organism: Caenorhabditis elegans
    Length: 458 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    chromatin [IEALink to PubMed article]
    Biological Process: negative regulation of vulval development [IMPLink to PubMed article]
    morphogenesis of an epithelium [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    chromatin assembly or disassembly [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    Molecular Function: chromatin binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEPKKEIIE DENHGISKKI PTDPRQYEKV TEGCRLLVMM ASQEEERWAE VISRCRAANG  60
   61 SIKFYVHYID CNRRLDEWVQ SDRLNLASCE LPKKGGKKGA HLREENRDSN ENEGKKSGRK 120
  121 RKIPLLPMDD LKAESVDPLQ AISTMTSGST PSLRGSMSMV GHSEDAMTRI RNVECIELGR 180
  181 SRIQPWYFAP YPQQLTSLDC IYICEFCLKY LKSKTCLKRH MEKCAMCHPP GNQIYSHDKL 240
  241 SFFEIDGRKN KSYAQNLCLL AKLFLDHKTL YYDTDPFLFY VLTEEDEKGH HIVGYFSKEK 300
  301 ESAEEYNVAC ILVLPPFQKK GYGSLLIEFS YELSKIEQKT GSPEKPLSDL GLLSYRSYWS 360
  361 MAIMKELFAF KRRHPGEDIT VQDISQSTSI KREDVVSTLQ QLDLYKYYKG SYIIVISDEK 420
  421 RQVYEKRIEA AKKKTRINPA ALQWRPKEYG KKRAQIMF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..161] PSI-BLAST 15.39794 Solution Structure of the Tudor Domain from Mouse Hypothetical Protein Homologous to Histone Acetyltransferase
    2 View Details [162..458] PSI-BLAST 107.0 No description for 2ou2A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • chromatin binding
    		•  3.84065302930105 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.64390820819794 bayes_pls_golite062009
  • methylated histone residue binding
    		•  3.42338304360938 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • protein binding
    		•  2.66728689880621 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  2.46353586381231 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • histone binding
    		•  2.00388175060339 bayes_pls_golite062009
  • transcription activator activity
    		•  1.46529895769882 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.10020047862576 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.998957812785999 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.75184432495983 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.726970683178132 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.494788451379878 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.294457188332415 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle