Protein Overview: pab-1

General Information:
Name(s) found:	pab-1 / CE20412 [WormBase]
Description(s) found: Found 20 descriptions. SHOW ALL	WBGene00003902 locus:pab-1 status:Confirmed UniProt:Q9U302 protein_id:CAA21572.1 [WormBase]
Organism:	Caenorhabditis elegans
Length:	646 amino acids
Gene Ontology:
Cellular Component:	nucleus [IEA]
Biological Process:	hermaphrodite genitalia development [IMP ] morphogenesis of an epithelium [IMP] positive regulation of growth rate [IMP ] embryonic development ending in birth or egg hatching [IMP] post-embryonic body morphogenesis [IMP] gamete generation [IMP ] mRNA processing [IEA] reproduction [IMP ]
Molecular Function:	nucleic acid binding [IEA] RNA binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEMNVAAPAA AVAGAAAPQP GQNQTGSSYT MASLYVGDLH PDVNESILFE KFSAAGPVLS  60
   61 IRVCRDNATR LSLGYAYVNF QQPADAERAM DTMNFEALHG KPMRIMWSQR DPAMRRSGAG 120
  121 NIFIKNLDKV IDNKSIYDTF SLFGNILSCK VAIDEDGFSK GYGFVHFETE EAAQNAIQKV 180
  181 NGMLLAGKKV FVGKFQPRAQ RNRELGETAK QFTNVYVKNF GDHYNKETLE KLFAKFGNIT 240
  241 SCEVMTVEGK SKGFGFVAFA NPEEAETAVQ ALHDSTIEGT DLKLHVCRAQ KKSERHAELK 300
  301 KKHEQHKAER MQKYQGVNLY VKNLDETVDD DGLKKQFESY GNITSAKVMT DENGRSKGFG 360
  361 FVCFEKPEEA TSAVTEMNSK MVCSKPLYVA IAQRKEDRRA QLASQYMQRL ASMRMHGNVP 420
  421 GAAMYNPTQP GPGYYVANPM QQQRNFAGGQ QMVRPGGRWG MQNQYPVQNQ YMMAQGPGVY 480
  481 QNRMGRPQNQ QGGPRGPPQQ YNQVAQGGVR MQGPPRTQNP GVQQQNVPRP PQQQQQQRPA 540
  541 PTGPKAPPQP YQAYQQRPQG IVIGGQEPLT SAMLAAAAPQ EQKQLLGERI YALIEKLYPG 600
  601 HKDAGKITGM MLEIDNSELI MMLQDSELFR SKVDEAASVL VSAQKQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	hcp-1	hcp1 IP from december2004	Cheeseman, I.M., et al. (2005)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..211]	PSI-BLAST	58.221849	Poly(A)-binding protein
2	View Details	[212..307]	PSI-BLAST	8.522879	No description for 2disA was found.
3	View Details	[308..394]	FFAS03	4.41	No description for 2f3jA was found.
4	View Details	[395..504]	deduced	N/A	No confident structure predictions are available.
5	View Details	[505..646]	PSI-BLAST	33.39794	poly(A) binding protein

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
RNA binding	6.73097473547076	bayes_pls_golite062009
	6.62953239642182	bayes_pls_golite062009
mRNA binding	5.29759606920196	bayes_pls_golite062009
nucleic acid binding	4.92126426323641	bayes_pls_golite062009
snRNA binding	4.06596327298973	bayes_pls_golite062009
binding	3.64400841800969	bayes_pls_golite062009
poly-pyrimidine tract binding	3.11990160533699	bayes_pls_golite062009
U1 snRNA binding	3.02511982045347	bayes_pls_golite062009
single-stranded RNA binding	2.93798024346416	bayes_pls_golite062009
transcription regulator activity	2.18211199677674	bayes_pls_golite062009
DNA binding	1.98418556946403	bayes_pls_golite062009
structural molecule activity	1.56454315220334	bayes_pls_golite062009
U2 snRNA binding	1.34078165372485	bayes_pls_golite062009
protein binding	1.12215421354121	bayes_pls_golite062009
transcription factor activity	1.07843408116687	bayes_pls_golite062009
mRNA 3'-UTR binding	0.824614388276642	bayes_pls_golite062009
sequence-specific DNA binding	0.383589644462932	bayes_pls_golite062009

2

Term	Confidence	Notes
RNA binding	6.73097473547076	bayes_pls_golite062009
	6.62953239642182	bayes_pls_golite062009
mRNA binding	5.29759606920196	bayes_pls_golite062009
nucleic acid binding	4.92126426323641	bayes_pls_golite062009
snRNA binding	4.06596327298973	bayes_pls_golite062009
binding	3.64400841800969	bayes_pls_golite062009
poly-pyrimidine tract binding	3.11990160533699	bayes_pls_golite062009
U1 snRNA binding	3.02511982045347	bayes_pls_golite062009
single-stranded RNA binding	2.93798024346416	bayes_pls_golite062009
transcription regulator activity	2.18211199677674	bayes_pls_golite062009
DNA binding	1.98418556946403	bayes_pls_golite062009
structural molecule activity	1.56454315220334	bayes_pls_golite062009
U2 snRNA binding	1.34078165372485	bayes_pls_golite062009
protein binding	1.12215421354121	bayes_pls_golite062009
transcription factor activity	1.07843408116687	bayes_pls_golite062009
mRNA 3'-UTR binding	0.824614388276642	bayes_pls_golite062009
sequence-specific DNA binding	0.383589644462932	bayes_pls_golite062009

3

No functions predicted.

4

No functions predicted.

5

Term	Confidence	Notes
RNA binding	5.69788763665792	bayes_pls_golite062009
mRNA binding	5.31297072316889	bayes_pls_golite062009
single-stranded RNA binding	4.51056428709072	bayes_pls_golite062009
nucleic acid binding	3.78909647605682	bayes_pls_golite062009
eukaryotic initiation factor 4G binding	3.4111148675327	bayes_pls_golite062009
binding	2.76167454154417	bayes_pls_golite062009
poly(A) RNA binding	2.66269581586161	bayes_pls_golite062009
poly-purine tract binding	2.20136693536924	bayes_pls_golite062009
ubiquitin-protein ligase activity	1.19350242454642	bayes_pls_golite062009
small conjugating protein ligase activity	1.14692713780316	bayes_pls_golite062009
protein binding	0.856075580719879	bayes_pls_golite062009
catalytic activity	0.287695754348243	bayes_pls_golite062009
acid-amino acid ligase activity	0.223805219849164	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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