Protein Overview: dpy-18

General Information:
Name(s) found:	dpy-18 / CE20261 [WormBase]
Description(s) found: SHOW ONLY BEST	WBGene00001077 locus:dpy-18 Prolyl 4-hydroxylase subunit alpha-1 status:Confirmed UniProt:Q10576 protein_id:CAA21045.1 [WormBase] pir\|\|T25418 hypothetical protein Y47D3B.10 - Caenorhabditis elegans [NCBI NR] gi\|6900013\|emb\|CAB71298.1\| prolyl 4-hydroxylase alpha subunit 1 [Caenorhabditis elegans] [NCBI NR] gi\|3881011\|emb\|CAA21045.1\| C. elegans protein Y47D3B.10, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|3880325\|emb\|CAB03452.1\| C. elegans protein Y47D3B.10, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR] gi\|20455505\|sp\|Q10576.2\|P4HA1_CAEEL RecName: Full=Prolyl 4-hydroxylase subunit alpha-1; AltName: Full=4-PH alpha-1; AltName: Full=Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1; AltName: Full=Protein dumpy-18; Flags: Precursor [NCBI NR] gi\|17552840\|ref\|NP_499464.1\| DumPY : shorter than wild-type family member (dpy-18) [Caenorhabditis elegans] [NCBI NR] Prolyl 4-hydroxylase subunit alpha-1 OS=Caenorhabditis elegans GN=dpy-18 PE=1 SV=2 [Swiss-Prot] (Q10576) Prolyl 4-hydroxylase alpha-1 subunit precursor (EC 1.14.11.2) (4-PH alpha-1) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit) [Swiss-Prot] [wormpep67.fasta] CE20261 WBGene00001077 locus:dpy-18 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PRECURSOR (EC 1.14.11.2) status:Confirmed SW:Q10576 protein_id:CAA21045.1 [wormpep150.fasta] 20261 WBGene00001077 locus:dpy-18 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PRECURSOR (EC 1.14.11.2) status:Confirmed SW:Q10576 protein_id:CAA21045.1 [wormpep130-phg-ecoli-orf-rand.fasta] DumPY : shorter than wild-type DPY-18, Proline HYdroxylase, prolyl 4-hydroxylase precursor, collagen modifying enzyme (63.9 kD) (dpy-18) [Caenorhabditis elegans]gi\|3880325\|emb\|CAB03452.1\| Hypothetical protein Y47D3B.10 [Caenorhabditis elegans]gi\|3881011 [nrdb_11152004_Chlamydomonas] locus:dpy-18 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PRECURSOR (EC 1.14.11.2) status:Confirmed SW:Q10576 protein_id:CAA21045.1 [wormpep115.fasta.reversed] CE20261 locus:dpy-18 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PRECURSOR (EC 1.14.11.2) status:Confirmed TR:O18153 protein_id:CAB03452.1 [wormpep80.hongbin] CE20261 WBGene00001077 locus:dpy-18 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PRECURSOR (EC 1.14.11.2) status:Confirmed UniProt:Q10576 protein_id:CAB03452.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta] CE20261 WBGene00001077 locus:dpy-18 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PRECURSOR (EC 1.14.11.2) status:Confirmed UniProt:Q10576 protein_id:CAB03452.1\| [wormORF-contam.fasta] Hypothetical protein Y47D3B.10 [Caenorhabditis elegans] [nr-271106-contam.fasta] DumPY : shorter than wild-type family member (dpy-18) [Caenorhabditis elegans] [nr-271106-contam.fasta] Prolyl 4-hydroxylase alpha-1 subunit precursor (4-PH alpha-1) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-1 subunit) (Protein dumpy-18) [nr-271106-contam.fasta] prolyl 4-hydroxylase alpha subunit 1 [Caenorhabditis elegans] [nr-271106-contam.fasta] [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr] CE20261 WBGene00001077 locus:dpy-18 PROLYL 4-HYDROXYLASE ALPHA SUBUNIT PRECURSOR (EC 1.14.11.2) status:Confirmed UniProt:Q10576 protein_id:CAA21045.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta] CE20261 WBGene00001077 locus:dpy-18 status:Confirmed UniProt:Q10576 protein_id:CAA21045.1 Prolyl 4-hydroxylase subunit alpha-1 [wormpep246-ecoli-contam.fasta]
Organism:	Caenorhabditis elegans
Length:	559 amino acids
Gene Ontology:
Cellular Component:	cell [IDA] endoplasmic reticulum [IDA]
Biological Process:	embryonic development [IMP] protein metabolic process [IEA] collagen and cuticulin-based cuticle development [IMP] locomotory behavior [IMP] positive regulation of multicellular organism growth [IMP ]
Molecular Function:	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLALLVLAT IGYAVADLFT SIADMQNLLE TERNIPKILD KYIHDEEERL VQLKKLSEEY  60
   61 SKKNEISIEN GLKDITNPIN AFLLIKRKIF DWKEIESKMN ANKAGNVVSS ITDDSYGVRY 120
  121 PTADDLSGAA IGLLRLQDTY RLDTKDLADG KIYADQGNYT FSAKDCFEIA RAAYNEHDFY 180
  181 HTVMWMEEAQ RRLGDEVEPT VEVEDILEYL AFALYKQNNL KHALKLTEEL YKMNPTHPRA 240
  241 KGNVKWYEDL LEQEGVRRSD MRKNLPPIQN RRPDSVLGNT ERTMYEALCR NEVPVSQKDI 300
  301 SRLYCYYKRD RPFLVYAPIK VEIKRFNPLA VLFKDVISDD EVAAIQELAK PKLARATVHD 360
  361 SVTGKLVTAT YRISKSAWLK EWEGDVVETV NKRIGYMTNL EMETAEELQI ANYGIGGHYD 420
  421 PHFDHAKKEE SKSFESLGTG NRIATVLFYM SQPSHGGGTV FTEAKSTILP TKNDALFWYN 480
  481 LYKQGDGNPD TRHAACPVLV GIKWVSNKWI HEKGNEFRRP CGLKSSDYER FVGDLGYGPE 540
  541 PRNAPNVSPN LAKDVWETL

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	hcp-1	hcp1 IP from december2004	Cheeseman, I.M., et al. (2005)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..326]	PSI-BLAST	26.045757	The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
2	View Details	[327..559]	FFAS03	5.66	No description for 2hbtA was found.

Protein Overview: dpy-18

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: