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View Structure Prediction Details

Protein: dpy-18
Organism: Caenorhabditis elegans
Length: 559 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dpy-18.

Description E-value Query
Range
Subject
Range
gi|50749316 - gi|50749316|ref|XP_421583.1| PREDICTED: similar to Prolyl 4-hydroxylase alpha-1 subunit (4-PH alpha-...
368.0 [0..4] [527..11]

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Predicted Domain #1
Region A:
Residues: [1-326]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRLALLVLAT IGYAVADLFT SIADMQNLLE TERNIPKILD KYIHDEEERL VQLKKLSEEY  60
   61 SKKNEISIEN GLKDITNPIN AFLLIKRKIF DWKEIESKMN ANKAGNVVSS ITDDSYGVRY 120
  121 PTADDLSGAA IGLLRLQDTY RLDTKDLADG KIYADQGNYT FSAKDCFEIA RAAYNEHDFY 180
  181 HTVMWMEEAQ RRLGDEVEPT VEVEDILEYL AFALYKQNNL KHALKLTEEL YKMNPTHPRA 240
  241 KGNVKWYEDL LEQEGVRRSD MRKNLPPIQN RRPDSVLGNT ERTMYEALCR NEVPVSQKDI 300
  301 SRLYCYYKRD RPFLVYAPIK VEIKRF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.045757
Match: 1w3bA
Description: The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
procollagen-proline 4-dioxygenase activity 7.0422525853653 bayes_pls_golite062009
procollagen-proline dioxygenase activity 7.0422525853653 bayes_pls_golite062009
peptidyl-proline dioxygenase activity 7.0422525853653 bayes_pls_golite062009
peptidyl-proline 4-dioxygenase activity 7.0422525853653 bayes_pls_golite062009
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors 5.01373106146099 bayes_pls_golite062009
binding 2.09193012129784 bayes_pls_golite062009
protein binding 1.52807685989528 bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor 0.534990536504941 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [327-559]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPLAVLFKDV ISDDEVAAIQ ELAKPKLARA TVHDSVTGKL VTATYRISKS AWLKEWEGDV  60
   61 VETVNKRIGY MTNLEMETAE ELQIANYGIG GHYDPHFDHA KKEESKSFES LGTGNRIATV 120
  121 LFYMSQPSHG GGTVFTEAKS TILPTKNDAL FWYNLYKQGD GNPDTRHAAC PVLVGIKWVS 180
  181 NKWIHEKGNE FRRPCGLKSS DYERFVGDLG YGPEPRNAPN VSPNLAKDVW ETL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.66
Match: 2hbtA
Description: No description for 2hbtA was found.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle