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Protein Overview: kpc-1

General Information:
Name(s) found: kpc-1 / CE17653 [WormBase]
Description(s) found:
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  • WBGene00002232 locus:kpc-1 status:Confirmed UniProt:O17797 protein_id:CAB04086.1 [WormBase]
  • pir||T20760 hypothetical protein F11A6.1a - Caenorhabditis elegans [NCBI NR]
  • gi|3875748|emb|CAB04086.1| C. elegans protein F11A6.1a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|25141268|ref|NP_492974.2| Kex-2 Proprotein Convertase family member (kpc-1) [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE17653 WBGene00002232 locus:kpc-1 Furin like serine protease status:Confirmed TR:O17797 protein_id:CAB04086.1 [wormpep150.fasta]
  • 17653 WBGene00002232 locus:kpc-1 Furin like serine protease status:Confirmed TR:O17797 protein_id:CAB04086.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • kex-2 Proprotein Convertase, furin endoprotease (77.1 kD) (kpc-1) [Caenorhabditis elegans]gi|3875748|emb|CAB04086.1| Hypothetical protein F11A6.1a [Caenorhabditis elegans]gi|7498889|pir||T20760 hypothetical protein F11A6.1a - Caenorhabditis elegans [nrdb_11152004_Chlamydomonas]
  • locus:kpc-1 Furin like serine protease status:Confirmed TR:O17797 protein_id:CAB04086.1 [wormpep115.fasta.reversed]
  • CE17653 locus:kpc-1 Furin like serine protease status:Confirmed TR:O17797 protein_id:CAB04086.1 [wormpep80.hongbin]
  • CE17653 WBGene00002232 locus:kpc-1 Furin like serine protease status:Confirmed UniProt:O17797_CAEEL protein_id:CAB04086.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE17653 WBGene00002232 locus:kpc-1 Furin like serine protease status:Confirmed UniProt:O17797_CAEEL protein_id:CAB04086.1| [wormORF-contam.fasta]
  • Kex-2 Proprotein Convertase family member (kpc-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein F11A6.1a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE17653 WBGene00002232 locus:kpc-1 Furin like serine protease status:Confirmed UniProt:O17797 protein_id:CAB04086.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE17653 WBGene00002232 locus:kpc-1 status:Confirmed UniProt:O17798 protein_id:CAB04086.1 [wormpep246-ecoli-contam.fasta]
  • CE17653 WBGene00002232 locus:kpc-1 status:Confirmed UniProt:O17798 protein_id:CAB04086.1 Furin-like protease kpc-1 [c_elegans-PRJNA13758-WS250-ecoli-contam.fasta]
  • Isoform of O17798, Isoform a of Furin-like protease kpc-1 OS=Caenorhabditis elegans GN=kpc-1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 692 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: proteolysis [IEALink to PubMed article]
    Molecular Function: subtilase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNISWYRHC SVRLQLVTLA LFLLLGSASL GSAHIDEEFE DDVTTTISSI ASPMRRTYTN  60
   61 EWAVRIAGGK VEEANRLANK YGYTNLGPII PGDEYYLFRD DRKKSRSSRK TRSLSANQLQ 120
  121 HEEDVMWMEQ QVAKRRVKRG YRRIRRHTDD NDIFEEDDDG TQISKSRNRK HPDPNDPLWT 180
  181 DMWYLNRGEH HSDSTTRMDH NVKEAWDLGY TGKGVVVTIL DDGLERTHPD ISPNYDERAS 240
  241 YDVNDRDNDP MPRYEFSDEN RHGTRCAGEV AAIFNNSLCI VGIAYNANIG GIRMLDGDVT 300
  301 DAVEAASVGH NADYIDIYSA SWGPDDDGRT VDGPAKLTRS AFEKGITMGR KGKGSIFVWA 360
  361 SGNGGKDADS CNCDGYTNSI YTLSISSATE NGNIPWYSEA CSSTLATTYS SGATGEKMIL 420
  421 TTDLHHACTN MHTGTSASAP LAAGIVALAL EANPNLTWRD LQHIVIRTAK PINLRAGDWT 480
  481 TNGVGRNVSH SFGYGLMDAG AMVKLAKIWK KVDEQHRCRQ FYPSRYKNIP NGNRLQLQLY 540
  541 SDGCYGGADE NKVSYVEHVQ AIVTLKAPKR GDLQIYLTSP SGTKSTLLTK RARDTSRSGF 600
  601 TDWAFMTTHN WGEQAAGLWI LEIDNDGWDD AELVKWELVL YGTDRETGDF GGQHASPLAV 660
  661 RSVQMEATSS GTQYSIFHVI TLVILTFSQI LY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..188] PSI-BLAST 41.30103 No description for 2p4eP was found.
    2 View Details [189..692] PSI-BLAST 99.0 Furin, C-terminal domain; Furin, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity, acting on L-amino acid peptides
    		•  3.71934851453379 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.15543200180944 bayes_pls_golite062009
  • peptidase activity
    		•  3.06116977101231 bayes_pls_golite062009
  • nerve growth factor binding
    		•  2.82265810193929 bayes_pls_golite062009
  • neurotrophin binding
    		•  2.36320382357038 bayes_pls_golite062009
  • hydrolase activity
    		•  2.05732080397524 bayes_pls_golite062009
  • eukaryotic cell surface binding
    		•  1.98332768179918 bayes_pls_golite062009
  • serine hydrolase activity
    		•  1.90036575189745 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  1.89198766955068 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  1.23150012549143 bayes_pls_golite062009
  • binding
    		•  1.08901362883653 bayes_pls_golite062009
  • cell surface binding
    		•  0.65732237084615 bayes_pls_golite062009
  • catalytic activity
    		•  0.597535457699629 bayes_pls_golite062009
  • protease binding
    		•  0.53239948404232 bayes_pls_golite062009
  • protein binding
    		•  0.380935140681308 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle