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Protein Overview: CE09597

General Information:
Name(s) found: CE09597 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00009082 locus:dlat-1 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial status:Confirmed UniProt:Q19749 protein_id:CAB01163.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 507 amino acids

    Gene Ontology:
    Cellular Component: pyruvate dehydrogenase complex [IEALink to PubMed article]
    oxoglutarate dehydrogenase complex [IEALink to PubMed article]
    Biological Process: positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed article]
    metabolic process [IEALink to PubMed article]
    glycolysis [IEALink to PubMed article]
    tricarboxylic acid cycle [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    pyruvate metabolic process [IEALink to PubMed article]
    Molecular Function: dihydrolipoyllysine-residue succinyltransferase activity [IEALink to PubMed article]
    protein binding [IEALink to PubMed article]
    acyltransferase activity [IEALink to PubMed article]
    dihydrolipoyllysine-residue acetyltransferase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKFPVPLRT IGGLRPSTTA AISAANIGFT QSSRALSTGA AAKSSGLVGQ VARQYPNAAA  60
   61 FSIKQVRLYS SGNLPKHNRV ALPALSPTME LGTVVSWQKK EGDQLSEGDL LCEIETDKAT 120
  121 MGFETPEEGY LAKILIQEGS KDVPIGKLLC IIVDNEADVA AFKDFKDDGA SSGGSAPAAE 180
  181 KAPEPAKPAA SSQPSPPAQM YQAPSVPKSA PIPHSSSGRV SASPFAKKLA AENGLDLSGV 240
  241 SGSGPGGRIL ASDLSQAPAK GATSTTTQAV SGQDYTDIPL SNMRKTIAKR LTESKSTIPH 300
  301 YYLTSEIQLD TLLQVREKLN GLLAKGTSGQ ATKISINDFI IKASALACQR VPEANSYWMD 360
  361 SFIRENHHVD VSVAVSTPAG LITPIIFNAH AKGLATIASE IVELAQRARE GKLQPHEFQG 420
  421 GTFTVSNLGM FGSVSDFTAI INPPQSCILA IGGASDKLVP DEAEGYKKIK TMKVTLSCDH 480
  481 RTVDGAVGAV WLRHFKEFLE KPHTMLL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..269] PSI-BLAST 25.221849 The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
    2 View Details [270..507] PSI-BLAST 85.39794 Dihydrolipoamide succinyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • dihydrolipoyllysine-residue acetyltransferase activity
    		•  9.65061123545754 bayes_pls_golite062009
  • dihydrolipoamide S-acyltransferase activity
    		•  9.64995677986911 bayes_pls_golite062009
  • S-acetyltransferase activity
    		•  9.49696044977584 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  8.45313874919036 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  8.17557182322815 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  6.40483178382327 bayes_pls_golite062009
  • acetyltransferase activity
    		•  6.08159176722072 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  5.93985773477717 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  5.74314131636952 bayes_pls_golite062009
  • acyltransferase activity
    		•  5.72047003788767 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  4.60481199262496 bayes_pls_golite062009
  • S-succinyltransferase activity
    		•  4.47883105509359 bayes_pls_golite062009
  • dihydrolipoyllysine-residue succinyltransferase activity
    		•  4.47883105509359 bayes_pls_golite062009
  • alpha-ketoacid dehydrogenase activity
    		•  4.42757758312016 bayes_pls_golite062009
  • carnitine O-acyltransferase activity
    		•  2.87366177129153 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  2.54513901872655 bayes_pls_golite062009
  • succinyltransferase activity
    		•  2.08404693277798 bayes_pls_golite062009
  • catalytic activity
    		•  1.51562638409295 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  1.33852311685118 bayes_pls_golite062009
  • carnitine O-palmitoyltransferase activity
    		•  1.22729402619659 bayes_pls_golite062009
  • O-palmitoyltransferase activity
    		•  1.22729402619659 bayes_pls_golite062009
  • transferase activity
    		•  1.08341671157927 bayes_pls_golite062009
  • carnitine O-acetyltransferase activity
    		•  1.00868366840715 bayes_pls_golite062009
  • binding
    		•  0.801074244553007 bayes_pls_golite062009
  • O-acetyltransferase activity
    		•  0.54660034926676 bayes_pls_golite062009
  • protein binding
    		•  0.00454070917775817 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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