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Protein Overview: egl-3

General Information:
Name(s) found: egl-3 / CE08940 [WormBase]
Description(s) found:
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  • WBGene00001172 locus:egl-3 status:Confirmed UniProt:G5ECN9 protein_id:CAB01635.1 [WormBase]
  • pir||T20131 proprotein convertase 2 (EC 3.4.21.94) precursor [similarity] - Caenorhabditis elegans [NCBI NR]
  • gi|71987206|ref|NP_001023732.1| EGg Laying defective family member (egl-3) [Caenorhabditis elegans] [NCBI NR]
  • gi|451657|gb|AAA56868.1| prohormone convertase 2 [Caenorhabditis elegans] [NCBI NR]
  • gi|3875147|emb|CAB01635.1| C. elegans protein C51E3.7a, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • ref|NP_505614.2| EGg Laying defective EGL-3, Kex-2 Proprotein Convertase (72.0 kD) (egl-3) [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • CE08940 WBGene00001172 locus:egl-3 prohormone convertase 2 status:Confirmed TR:Q10575 protein_id:CAB01635.1 [wormpep150.fasta]
  • 08940 WBGene00001172 locus:egl-3 prohormone convertase 2 status:Confirmed TR:Q10575 protein_id:CAB01635.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • EGg Laying defective EGL-3, Kex-2 Proprotein Convertase (72.0 kD) (egl-3) [Caenorhabditis elegans]gi|3875147|emb|CAB01635.1| Hypothetical protein C51E3.7a [Caenorhabditis elegans]gi|451657|gb|AAA56868.1| prohormone convertase 2 [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • locus:egl-3 prohormone convertase 2 status:Confirmed TR:Q10575 protein_id:CAB01635.1 [wormpep115.fasta.reversed]
  • CE08940 locus:egl-3 prohormone convertase 2 status:Confirmed TR:Q10575 protein_id:CAB01635.1 [wormpep80.hongbin]
  • CE08940 WBGene00001172 locus:egl-3 prohormone convertase 2 status:Confirmed UniProt:Q10575_CAEEL protein_id:CAB01635.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE08940 WBGene00001172 locus:egl-3 prohormone convertase 2 status:Confirmed UniProt:Q10575_CAEEL protein_id:CAB01635.1| [wormORF-contam.fasta]
  • prohormone convertase 2 [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • Hypothetical protein C51E3.7a [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • EGg Laying defective family member (egl-3) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE08940 WBGene00001172 locus:egl-3 prohormone convertase 2 status:Confirmed UniProt:Q10575 protein_id:CAB01635.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE08940 WBGene00001172 locus:egl-3 prohormone convertase 2 status:Confirmed UniProt:G5ECN9 protein_id:CAB01635.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • CE08940 WBGene00001172 locus:egl-3 status:Confirmed UniProt:G5ECN9 protein_id:CAB01635.1 [wormpep246-ecoli-contam.fasta]
  • Prohormone convertase 2 OS=Caenorhabditis elegans GN=egl-3 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 652 amino acids

    Gene Ontology:
    Cellular Component: axon [IDALink to PubMed article]
    Biological Process: proteolysis [IEALink to PubMed article]
    Molecular Function: subtilase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNTHVDLIC VFLSIFIGIG EAVDVYTNHF HVHLKEGGGL EDAHRIAKRH GFINRGQVAA  60
   61 SDNEYHFVQP ALVHARTRRS AGHHAKLHND DEVLHVEQLK GYTRTKRGYR PLEQRLESQF 120
  121 DFSAVMSPSD PLYGYQWYLK NTGQAGGKAR LDLNVERAWA MGFTGKNITT AIMDDGVDYM 180
  181 HPDIKNNFNA EASYDFSSND PFPYPRYTDD WFNSHGTRCA GEIVAARDNG VCGVGVAYDG 240
  241 KVAGIRMLDQ PYMTDLIEAN SMGHEPSKIH IYSASWGPTD DGKTVDGPRN ATMRAIVRGV 300
  301 NEGRNGLGSI FVWASGDGGE DDDCNCDGYA ASMWTISINS AINNGENAHY DESCSSTLAS 360
  361 TFSNGGRNPE TGVATTDLYG RCTRSHSGTS AAAPEAAGVF ALALEANPSL TWRDLQHLTV 420
  421 LTSSRNSLFD GRCRDFPSLG INDNHRDSHG NCSHFEWQMN GVGLEYNHLF GFGVLDAAEM 480
  481 VMLAMAWKTS PPRYHCTAGL IDTPHEIPAD GNLILEINTD GCAGSQFEVR YLEHVQAVVS 540
  541 FNSTRRGDTT LYLISPMGTR TMILSRRPKD DDSKDGFTNW PFMTTHTWGE NPTGKWRLVA 600
  601 RFQGPGAHAG TLKKFELMLH GTREAPYNLI EPIVGQTNKK LDTVQKAHKR SH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..130] PSI-BLAST 36.39794 No description for 2p4eP was found.
    2 View Details [131..652] PSI-BLAST 91.39794 Furin, C-terminal domain; Furin, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • nerve growth factor binding
    		•  5.17216805931457 bayes_pls_golite062009
  • peptidase activity
    		•  4.77677490610016 bayes_pls_golite062009
  • neurotrophin binding
    		•  4.47215080222714 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  4.40501322467328 bayes_pls_golite062009
  • serine hydrolase activity
    		•  4.30899317351154 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  4.29545891350519 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.83336601331518 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  3.71508033196614 bayes_pls_golite062009
  • hydrolase activity
    		•  2.05732080397524 bayes_pls_golite062009
  • protein binding
    		•  1.53121577002039 bayes_pls_golite062009
  • cell surface binding
    		•  1.35082641853563 bayes_pls_golite062009
  • binding
    		•  1.28749522568113 bayes_pls_golite062009
  • receptor binding
    		•  1.25719003525894 bayes_pls_golite062009
  • heparin binding
    		•  0.876342157478361 bayes_pls_golite062009
  • protease binding
    		•  0.70588409047823 bayes_pls_golite062009
  • eukaryotic cell surface binding
    		•  0.64950741809726 bayes_pls_golite062009
  • catalytic activity
    		•  0.597535457699629 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  0.57147918956324 bayes_pls_golite062009
  • growth factor binding
    		•  0.543263320403739 bayes_pls_golite062009
  • exopeptidase activity
    		•  0.42083764849682 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.10343618041863 bayes_pls_golite062009
  • low-density lipoprotein receptor binding
    		•  0.0535137917871995 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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