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Protein Overview: aha-1

General Information:
Name(s) found: aha-1 / CE08377 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00000095 locus:aha-1 Aryl hydrocarbon receptor nuclear translocator homolog status:Confirmed UniProt:O02219 protein_id:CAB02764.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 453 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    intracellular [TASLink to PubMed article]
    Biological Process: locomotory behavior [IMPLink to PubMed article]
    signal transduction [IEALink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    response to xenobiotic stimulus [IDALink to PubMed article]
    regulation of transcription [IEALink to PubMed article][ISSLink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed article]
    intracellular receptor mediated signaling pathway [TASLink to PubMed article]
    positive regulation of locomotion [IMPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    aryl hydrocarbon receptor nuclear translocator activity [ISSLink to PubMed article]
    transcription regulator activity [IEALink to PubMed article][TASLink to PubMed article]
    signal transducer activity [IEALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQDIFMDPW QSATSFAMED EDMGMPSGKY ARMEDEMGEN KERFARENHS EIERRRRNKM  60
   61 THYINELAEM VPQCASLGRK PDKLTILRMA VSHMKGIRGH TAQDETSYKP SFLTDQELKH 120
  121 LILEAANGFL FVVCCQTGKV LYVADSITPV LNLKQEDWLQ RNLNELIHPD DQDKIRDQLC 180
  181 GSEVSVNKVL DLKSGSVKRE GASTRVHMSC RRGFICRMRV GALEPLHRLR NRRPLFQHAG 240
  241 QNYVVMHCTG YIKNAPPQGI NAPASSCLVA IARLQVASMP VCADPTSTNQ FSVRVSEDGK 300
  301 MTFIDARVSD LIGLSSDQLI GRYWWNLAHP ADEKTLQDSF VALLSDQPMR INIRVRTSTD 360
  361 YIPCTVSAYK FMNPYSEQFE YVVATHQIAP QEDINNWVTA PTVPQPQASE FGELGGAPSA 420
  421 VDYGQSSSGG WRPEAQGAPQ AQWQWDPMNG YNQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..112] PSI-BLAST 5.522879 SREBP-1a
    2 View Details [113..453] PSI-BLAST 26.69897 Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  5.38658950816179 bayes_pls_golite062009
  • DNA binding
    		•  5.18654839258297 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.05768805749761 bayes_pls_golite062009
  • transcription factor activity
    		•  4.78039531631248 bayes_pls_golite062009
  • transcription activator activity
    		•  3.87875547821718 bayes_pls_golite062009
  • binding
    		•  3.81829206350975 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.42035985454056 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.39500382187264 bayes_pls_golite062009
  • protein binding
    		•  2.64975291677725 bayes_pls_golite062009
  • transcription factor binding
    		•  2.61163564741984 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.58751248599889 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  2.42306484786159 bayes_pls_golite062009
  • transcription corepressor activity
    		•  2.03674713048499 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.52770895937238 bayes_pls_golite062009
  • promoter binding
    		•  0.8576109846276 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.53175615551166 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.3513586903977 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.20674648626116 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle