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View Structure Prediction Details

Protein: aha-1
Organism: Caenorhabditis elegans
Length: 453 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for aha-1.

Description E-value Query
Range
Subject
Range
CE44231 - WBGene00000095 locus:aha-1 Aryl hydrocarbon receptor nuclear translocator homolog status:Confirmed U...
227.0 [0..1] [453..1]

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Predicted Domain #1
Region A:
Residues: [1-112]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAQDIFMDPW QSATSFAMED EDMGMPSGKY ARMEDEMGEN KERFARENHS EIERRRRNKM  60
   61 THYINELAEM VPQCASLGRK PDKLTILRMA VSHMKGIRGH TAQDETSYKP SF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1am9A
Description: SREBP-1a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.38658950816179 bayes_pls_golite062009
DNA binding 5.18654839258297 bayes_pls_golite062009
nucleic acid binding 5.05768805749761 bayes_pls_golite062009
transcription factor activity 4.78039531631248 bayes_pls_golite062009
transcription activator activity 3.87875547821718 bayes_pls_golite062009
binding 3.81829206350975 bayes_pls_golite062009
sequence-specific DNA binding 3.42035985454056 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.39500382187264 bayes_pls_golite062009
protein binding 2.64975291677725 bayes_pls_golite062009
transcription factor binding 2.61163564741984 bayes_pls_golite062009
transcription repressor activity 2.58751248599889 bayes_pls_golite062009
RNA polymerase II transcription factor activity, enhancer binding 2.42306484786159 bayes_pls_golite062009
transcription corepressor activity 2.03674713048499 bayes_pls_golite062009
transcription cofactor activity 1.52770895937238 bayes_pls_golite062009
promoter binding 0.8576109846276 bayes_pls_golite062009
protein heterodimerization activity 0.53175615551166 bayes_pls_golite062009
transcription coactivator activity 0.3513586903977 bayes_pls_golite062009
protein dimerization activity 0.20674648626116 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [113-453]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LTDQELKHLI LEAANGFLFV VCCQTGKVLY VADSITPVLN LKQEDWLQRN LNELIHPDDQ  60
   61 DKIRDQLCGS EVSVNKVLDL KSGSVKREGA STRVHMSCRR GFICRMRVGA LEPLHRLRNR 120
  121 RPLFQHAGQN YVVMHCTGYI KNAPPQGINA PASSCLVAIA RLQVASMPVC ADPTSTNQFS 180
  181 VRVSEDGKMT FIDARVSDLI GLSSDQLIGR YWWNLAHPAD EKTLQDSFVA LLSDQPMRIN 240
  241 IRVRTSTDYI PCTVSAYKFM NPYSEQFEYV VATHQIAPQE DINNWVTAPT VPQPQASEFG 300
  301 ELGGAPSAVD YGQSSSGGWR PEAQGAPQAQ WQWDPMNGYN Q

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 26.69897
Match: 1wa9A
Description: Crystal Structure of the PAS repeat region of the Drosophila clock protein PERIOD
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
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