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Protein Overview: hsp-70

General Information:
Name(s) found: hsp-70 / CE08110 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00002026 locus:hsp-70 status:Partially_confirmed UniProt:O45246 protein_id:CAB03871.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 643 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: endoplasmic reticulum unfolded protein response [IEPLink to PubMed article]
    determination of adult lifespan [IGILink to PubMed article]
    cell morphogenesis [IEALink to PubMed article]
    protein folding [IEALink to PubMed article]
    iron-sulfur cluster assembly [IEALink to PubMed article]
    Molecular Function: ATPase activity [IEALink to PubMed article]
    ATP binding [IEALink to PubMed article]
    unfolded protein binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTCKAIGID LGTTYSCVGI YQNGKVEILA NSEGNKTTPS YVAFTDTERL VGDAAKDQAA  60
   61 RNPENTVFDA KRLIGRRFDE ETVQSDIKHW PFTVKGKQGK PVVEVEVKGE KREFNAEEIS 120
  121 AMVLQKMKET AEAVLGHSVR DAVITVPAYF NDSQRQATKD AATIAGLNAI RIINEPTAAA 180
  181 LAYGLDKGIT DEKNILIFDL GGGTFDVSIL SIAEGSIFEV KSTAGDTHLG GEDFDSRVLQ 240
  241 HFMTEFKRKT GKDISSNPRA IRRLRTACER AKRTLSSSTE ATVEVDSLFD GTDFYSKITR 300
  301 ARFEELCADL FRKTLEPVEK ALRDAKTDKG RIDEVVLVGG STRIPKIQKL LKEFFNGKDL 360
  361 NCSINPDEAV AFGAAVQAAV LSGVKDDTIK DVLLVDVVPL SHGIETAGGV MTNLIDRNTR 420
  421 IPAKASKTFT TYADNQPGVS IQVYEGERAM TRDNHRLGTF ELTGIPPAPR GVPQVDVTFD 480
  481 IDANGILNVS AADKSTGRSN RITIRNEKGR LSQADIDRMV NEAKQFERED AAQRDRISSR 540
  541 NQLEAYAFQV KQALEEHGSL LSAEDAKRAK DAVEDTLRWM ERNTLADKDE IEAKDKELKS 600
  601 ICQDILTKMH QQEAQSGSGC GNPGSGGFHS SNYPQGPTVE EVD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run None Entered No Comments Cheeseman, I.M., et al. (2004)
    View Run hcp-1 hcp1 IP from december2004 Cheeseman, I.M., et al. (2005)
    View Run hcp-2 hcp2 ip from december Cheeseman, I.M., et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..560] PSI-BLAST 1000.0 crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant
    2 View Details [561..643] PSI-BLAST 55.69897 DnaK

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  7.97191512372019 bayes_pls_golite062009
  • structural molecule activity
    		•  3.59589495899762 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.46121037473545 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  2.33338276303563 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.20983242331685 bayes_pls_golite062009
  • binding
    		•  2.11855816699924 bayes_pls_golite062009
  • protein binding
    		•  2.00711904074672 bayes_pls_golite062009
  • hydrolase activity
    		•  1.88613511243568 bayes_pls_golite062009
  • hexokinase activity
    		•  1.70516840340504 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68670098354938 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.43834016708999 bayes_pls_golite062009
  • peptidase activity
    		•  1.4127499531612 bayes_pls_golite062009
  • DNA binding
    		•  1.36804228074586 bayes_pls_golite062009
  • transporter activity
    		•  1.2883466875237 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.16749728168925 bayes_pls_golite062009
  • kinase activity
    		•  1.11102445353265 bayes_pls_golite062009
  • actin binding
    		•  1.03829083423378 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.953663805249074 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.900931843471417 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.898645342556399 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.875671218597808 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.796517590178929 bayes_pls_golite062009
  • transcription factor activity
    		•  0.783439770973386 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.78242344952806 bayes_pls_golite062009
  • protein transporter activity
    		•  0.780308299678282 bayes_pls_golite062009
  • ATPase activity
    		•  0.687771333492666 bayes_pls_golite062009
  • myosin binding
    		•  0.607451856096 bayes_pls_golite062009
  • glucose binding
    		•  0.53527958884988 bayes_pls_golite062009
  • glucokinase activity
    		•  0.47468456642723 bayes_pls_golite062009
  • catalytic activity
    		•  0.296484721581333 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.186218331473028 bayes_pls_golite062009
  • chromatin binding
    		•  0.155140608043269 bayes_pls_golite062009
  • protease binding
    		•  0.121259015422625 bayes_pls_golite062009
  • chaperone binding
    		•  0.00111313452804307 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle