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Protein Overview: vha-15

General Information:
Name(s) found: vha-15 / CE07497 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00020507 locus:vha-15 Probable V-type proton ATPase subunit H 2 status:Confirmed UniProt:Q22494 protein_id:CCD68940.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 470 amino acids

    Gene Ontology:
    Cellular Component: vacuolar proton-transporting V-type ATPase, V1 domain [IEALink to PubMed article]
    peripheral to membrane of membrane fraction [IEALink to PubMed article]
    Biological Process: collagen and cuticulin-based cuticle attachment to epithelium [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed articleLink to PubMed article]
    locomotion [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    ATP synthesis coupled proton transport [IEALink to PubMed article]
    growth [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    proton-transporting ATPase activity, rotational mechanism [IEALink to PubMed article]
    hydrogen ion transporting ATP synthase activity, rotational mechanism [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEVPHHNIP AVDMLNATSR LQLEAQELRN NKPNWGSYFR SQMIQEDDYN FITSFENAKS  60
   61 KEERDQVLAA NNANGQAAKT MANLITQVAK DQNVRYVLTL FDDMLQEDKS RVELFHSAAA 120
  121 RQKRTVWSQY LGILQRQDNF IVNQMSSIIA KLACFGTTRM EGQDLQYYFS FLKEQLKNST 180
  181 TNDYMNTTAR CLQMMLRHDE YRHEFVDSDG VQTLVTALNG KTNFQLQYQL IFAVWCLTFN 240
  241 ADIARKAPSL GLIQALGDIL SESTKEKVIR IILASFVNIL SKVDEREVKR EAALQMVQCK 300
  301 TLKTLELMDA KKYDDPDLED DVKFLTEELT LSVHDLSSYD EYYSEVRSGR LQWSPVHKSE 360
  361 KFWRENASKF NDKQFEVVKI LIKLLESSHD PLILCVASHD IGEYVRHYPR GKTVVEQYQG 420
  421 KAAVMRLLTA EDPNVRYHAL LAVQKLMVHN WEYLGKQLDS DVQTDTVAVK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..470] PSI-BLAST 78.39794 Regulatory subunit H of the V-type ATPase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrogen ion transmembrane transporter activity
    		•  8.27793692177437 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  6.61991113486273 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  5.91856058767561 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  3.08652472111805 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.01705909078235 bayes_pls_golite062009
  • protein transporter activity
    		•  2.91465420196082 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.62570967627286 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.5665080711484 bayes_pls_golite062009
  • transporter activity
    		•  2.48700774379895 bayes_pls_golite062009
  • binding
    		•  2.4389817190572 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.26725422172281 bayes_pls_golite062009
  • clathrin binding
    		•  2.07672364145383 bayes_pls_golite062009
  • RNA binding
    		•  1.90677197622326 bayes_pls_golite062009
  • protein binding
    		•  1.63705839411934 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  1.60849969922683 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.28481004323799 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.02389895825558 bayes_pls_golite062009
  • hydrolase activity
    		•  0.528047226063932 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.294257360897755 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.252495966234234 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.226380819487924 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.217517113570989 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.178770060806735 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.175241020572885 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.174922130116569 bayes_pls_golite062009
  • signal sequence binding
    		•  0.14931345687137 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.100181463251306 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  0.0949889863173228 bayes_pls_golite062009
  • signal transducer activity
    		•  0.0689818654521059 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.0689818654521059 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0635404099346928 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0548082069333885 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.052195223119721 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle