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Protein Overview: cel-1

General Information:
Name(s) found: cel-1 / CE05197 [WormBase]
Description(s) found:
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  • WBGene00000466 locus:cel-1 status:Confirmed UniProt:Q6A3Q2 protein_id:CAH10769.1 [WormBase]
  • gi|71980523|ref|NP_001020980.1| mRNA Capping Enzyme Like family member (cel-1) [Caenorhabditis elegans] [NCBI NR]
  • gi|50978530|emb|CAH10769.1| C. elegans protein C03D6.3b, confirmed by transcript evidence [Caenorhabditis elegans] [NCBI NR]
  • gi|2198830|gb|AAB61344.1| mRNA capping enzyme [Caenorhabditis elegans] [NCBI NR]
  • [wormpep67.fasta]
  • Hypothetical protein C03D6.3b [Caenorhabditis elegans]gi|2198830|gb|AAB61344.1| mRNA capping enzyme [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE05197 WBGene00000466 locus:cel-1 status:Confirmed TR:Q6A3Q2 protein_id:CAH10769.1 [wormpep150.fasta]
  • 05197 WBGene00000466 locus:cel-1 status:Confirmed protein_id:CAH10769.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • CE05197 WBGene00000466 locus:cel-1 status:Confirmed protein_id:CAH10769.1 [wormpep132.fasta]
  • 05197 WBGene00000466 locus:cel-1 status:Confirmed TR:Q6A3Q2 protein_id:CAH10769.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • CE05197 WBGene00000466 locus:cel-1 status:Confirmed UniProt:Q6A3Q2_CAEEL protein_id:CAH10769.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE05197 WBGene00000466 locus:cel-1 status:Confirmed UniProt:Q6A3Q2_CAEEL protein_id:CAH10769.1| [wormORF-contam.fasta]
  • Hypothetical protein C03D6.3b [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • mRNA Capping Enzyme Like family member (cel-1) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • mRNA capping enzyme [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE05197 WBGene00000466 locus:cel-1 status:Confirmed UniProt:Q6A3Q2 protein_id:CAH10769.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • Isoform of Q17607, mRNA Capping Enzyme Like OS=Caenorhabditis elegans GN=cel-1 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 573 amino acids

    Gene Ontology:
    Cellular Component: intracellular [TASLink to PubMed article]
    Biological Process: DNA repair [IEALink to PubMed article]
    molting cycle, protein-based cuticle [IMPLink to PubMed article]
    mRNA capping [IEALink to PubMed article][ISSLink to PubMed article]
    DNA replication [IEALink to PubMed article]
    post-embryonic body morphogenesis [IMPLink to PubMed articleLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    protein amino acid dephosphorylation [IEALink to PubMed article]
    DNA recombination [IEALink to PubMed article]
    gamete generation [IMPLink to PubMed article]
    mRNA processing [IEALink to PubMed article]
    positive regulation of multicellular organism growth [IMPLink to PubMed articleLink to PubMed article]
    growth [IMPLink to PubMed article]
    reproduction [IMPLink to PubMed article]
    positive regulation of locomotion [IMPLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    morphogenesis of an epithelium [IMPLink to PubMed article]
    dephosphorylation [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    DNA ligase (ATP) activity [IEALink to PubMed article]
    protein tyrosine phosphatase activity [IEALink to PubMed article]
    RNA-dependent ATPase activity [ISSLink to PubMed article]
    phosphatase activity [IEALink to PubMed article]
    mRNA guanylyltransferase activity [IEALink to PubMed article]
    protein tyrosine/serine/threonine phosphatase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLPDRWLHC PKTGTLINNL FFPFKTPLCK MYDNQIAERR YQFHPAEVFS HPHLHGKKIG  60
   61 LWIDLTNTDR YYFREEVTEH ECIYHKMKMA GRGVSPTQED TDNFIKLVQE FHKKYPDRVV 120
  121 GVHCTHGFNR TGFLIAAYLF QVEEYGLDAA IGEFAENRQK GIYKQDYIDD LFARYDPTED 180
  181 DKILAPEKPD WEREMSIGMS TQIDNGRPST SQQIPATNGN NNQNGNQLSG GGDNSKLFMD 240
  241 GLIRGVKVCE DEGKKSMLQA KIKNLCKYNK QGFPGLQPVS LSRGNINLLE QESYMVSWKA 300
  301 DGMRYIIYIN DGDVYAFDRD NEVFEIENLD FVTKNGAPLM ETLVDTEVII DKVEINGAMC 360
  361 DQPRMLIYDI MRFNSVNVMK EPFYKRFEII KTEIIDMRTA AFKTGRLKHE NQIMSVRRKD 420
  421 FYDLEATAKL FGPKFVQHVG HEIDGLIFQP KKTKYETGRC DKVLKWKPPS HNSVDFLLKV 480
  481 EKKCKEGMLP EWIGYLFVQN LSDPFGTMKA TATLKKYHNK IIECTLLVDN QGRPKEWKFM 540
  541 RERTDKSLPN GLRTAENVVE TMVNPVTETY LIE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..196] PSI-BLAST 32.69897 CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase
    2 View Details [197..359] FFAS03 2.38 RNA guanylyltransferase (mRNA capping enzyme); RNA guanylyltransferase (mRNA capping enzyme), N-terminal domain
    3 View Details [360..573] PSI-BLAST 53.522879 Crystal Structure of Human DNA Ligase I bound to 5'-adenylated, nicked DNA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • mRNA guanylyltransferase activity
    		•  8.44951560480445 bayes_pls_golite062009
  • RNA guanylyltransferase activity
    		•  8.02773775185769 bayes_pls_golite062009
  • guanylyltransferase activity
    		•  5.17049957294188 bayes_pls_golite062009
  • ligase activity
    		•  2.32117041900947 bayes_pls_golite062009
  • ligase activity, forming phosphoric ester bonds
    		•  2.12202868529213 bayes_pls_golite062009
  • DNA ligase activity
    		•  2.10005856611468 bayes_pls_golite062009
  • catalytic activity
    		•  1.98004058504857 bayes_pls_golite062009
  • binding
    		•  1.6492328714954 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.36512645572174 bayes_pls_golite062009
  • DNA binding
    		•  1.30570045339175 bayes_pls_golite062009
  • DNA ligase (ATP) activity
    		•  0.353057247533014 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.293080071585386 bayes_pls_golite062009
  • protein binding
    		•  0.244939883018638 bayes_pls_golite062009
  • ATP binding
    		•  0.0764964990255529 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.0486642748854728 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.0414617030999805 bayes_pls_golite062009
    3
    Term Confidence Notes
  • mRNA guanylyltransferase activity
    		•  8.90512192081791 bayes_pls_golite062009
  • RNA guanylyltransferase activity
    		•  8.46124967325993 bayes_pls_golite062009
  • guanylyltransferase activity
    		•  5.45528434251369 bayes_pls_golite062009
  • ligase activity, forming phosphoric ester bonds
    		•  2.90848936326491 bayes_pls_golite062009
  • DNA ligase activity
    		•  2.88630907730339 bayes_pls_golite062009
  • ligase activity
    		•  2.7348192562888 bayes_pls_golite062009
  • catalytic activity
    		•  2.15370807854636 bayes_pls_golite062009
  • binding
    		•  1.63149986094272 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.39097817404242 bayes_pls_golite062009
  • DNA binding
    		•  1.33524321669723 bayes_pls_golite062009
  • DNA ligase (ATP) activity
    		•  1.02324195596817 bayes_pls_golite062009
  • DNA ligase (NAD+) activity
    		•  0.571203360462711 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.287720615514972 bayes_pls_golite062009
  • protein binding
    		•  0.229784545879049 bayes_pls_golite062009
  • ATP binding
    		•  0.17947590671995 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.148991737494582 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.138964074823321 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle