Protein Overview: cel-1

General Information:
Name(s) found:	cel-1 / CE05197 [WormBase]
Description(s) found: Found 18 descriptions. SHOW ALL	WBGene00000466 locus:cel-1 status:Confirmed UniProt:Q6A3Q2 protein_id:CAH10769.1 [WormBase]
Organism:	Caenorhabditis elegans
Length:	573 amino acids
Gene Ontology:
Cellular Component:	intracellular [TAS]
Biological Process:	DNA repair [IEA] molting cycle, protein-based cuticle [IMP] mRNA capping [IEA][ISS] DNA replication [IEA] post-embryonic body morphogenesis [IMP ] positive regulation of growth rate [IMP] embryonic development ending in birth or egg hatching [IMP ] protein amino acid dephosphorylation [IEA] DNA recombination [IEA] gamete generation [IMP] mRNA processing [IEA] positive regulation of multicellular organism growth [IMP ] growth [IMP] reproduction [IMP] positive regulation of locomotion [IMP] locomotory behavior [IMP] nematode larval development [IMP] morphogenesis of an epithelium [IMP] dephosphorylation [IEA]
Molecular Function:	ATP binding [IEA] DNA ligase (ATP) activity [IEA] protein tyrosine phosphatase activity [IEA] RNA-dependent ATPase activity [ISS] phosphatase activity [IEA] mRNA guanylyltransferase activity [IEA] protein tyrosine/serine/threonine phosphatase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLPDRWLHC PKTGTLINNL FFPFKTPLCK MYDNQIAERR YQFHPAEVFS HPHLHGKKIG  60
   61 LWIDLTNTDR YYFREEVTEH ECIYHKMKMA GRGVSPTQED TDNFIKLVQE FHKKYPDRVV 120
  121 GVHCTHGFNR TGFLIAAYLF QVEEYGLDAA IGEFAENRQK GIYKQDYIDD LFARYDPTED 180
  181 DKILAPEKPD WEREMSIGMS TQIDNGRPST SQQIPATNGN NNQNGNQLSG GGDNSKLFMD 240
  241 GLIRGVKVCE DEGKKSMLQA KIKNLCKYNK QGFPGLQPVS LSRGNINLLE QESYMVSWKA 300
  301 DGMRYIIYIN DGDVYAFDRD NEVFEIENLD FVTKNGAPLM ETLVDTEVII DKVEINGAMC 360
  361 DQPRMLIYDI MRFNSVNVMK EPFYKRFEII KTEIIDMRTA AFKTGRLKHE NQIMSVRRKD 420
  421 FYDLEATAKL FGPKFVQHVG HEIDGLIFQP KKTKYETGRC DKVLKWKPPS HNSVDFLLKV 480
  481 EKKCKEGMLP EWIGYLFVQN LSDPFGTMKA TATLKKYHNK IIECTLLVDN QGRPKEWKFM 540
  541 RERTDKSLPN GLRTAENVVE TMVNPVTETY LIE

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..196]	PSI-BLAST	32.69897	CRYSTAL STRUCTURE OF THE HUMAN RNA guanylyltransferase and 5'- phosphatase
2	View Details	[197..359]	FFAS03	2.38	RNA guanylyltransferase (mRNA capping enzyme); RNA guanylyltransferase (mRNA capping enzyme), N-terminal domain
3	View Details	[360..573]	PSI-BLAST	53.522879	Crystal Structure of Human DNA Ligase I bound to 5'-adenylated, nicked DNA

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

Term	Confidence	Notes
mRNA guanylyltransferase activity	8.44951560480445	bayes_pls_golite062009
RNA guanylyltransferase activity	8.02773775185769	bayes_pls_golite062009
guanylyltransferase activity	5.17049957294188	bayes_pls_golite062009
ligase activity	2.32117041900947	bayes_pls_golite062009
ligase activity, forming phosphoric ester bonds	2.12202868529213	bayes_pls_golite062009
DNA ligase activity	2.10005856611468	bayes_pls_golite062009
catalytic activity	1.98004058504857	bayes_pls_golite062009
binding	1.6492328714954	bayes_pls_golite062009
nucleic acid binding	1.36512645572174	bayes_pls_golite062009
DNA binding	1.30570045339175	bayes_pls_golite062009
DNA ligase (ATP) activity	0.353057247533014	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.293080071585386	bayes_pls_golite062009
protein binding	0.244939883018638	bayes_pls_golite062009
ATP binding	0.0764964990255529	bayes_pls_golite062009
adenyl ribonucleotide binding	0.0486642748854728	bayes_pls_golite062009
adenyl nucleotide binding	0.0414617030999805	bayes_pls_golite062009

3

Term	Confidence	Notes
mRNA guanylyltransferase activity	8.90512192081791	bayes_pls_golite062009
RNA guanylyltransferase activity	8.46124967325993	bayes_pls_golite062009
guanylyltransferase activity	5.45528434251369	bayes_pls_golite062009
ligase activity, forming phosphoric ester bonds	2.90848936326491	bayes_pls_golite062009
DNA ligase activity	2.88630907730339	bayes_pls_golite062009
ligase activity	2.7348192562888	bayes_pls_golite062009
catalytic activity	2.15370807854636	bayes_pls_golite062009
binding	1.63149986094272	bayes_pls_golite062009
nucleic acid binding	1.39097817404242	bayes_pls_golite062009
DNA binding	1.33524321669723	bayes_pls_golite062009
DNA ligase (ATP) activity	1.02324195596817	bayes_pls_golite062009
DNA ligase (NAD+) activity	0.571203360462711	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.287720615514972	bayes_pls_golite062009
protein binding	0.229784545879049	bayes_pls_golite062009
ATP binding	0.17947590671995	bayes_pls_golite062009
adenyl ribonucleotide binding	0.148991737494582	bayes_pls_golite062009
adenyl nucleotide binding	0.138964074823321	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle