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Protein Overview: ced-4

General Information:
Name(s) found: ced-4 / CE01203 [WormBase]
Description(s) found:
Found 27 descriptions.
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  • WBGene00000418 locus:ced-4 Cell death protein 4 status:Confirmed UniProt:P30429 protein_id:CCD66781.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 549 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDALink to PubMed article]
    perinuclear region of cytoplasm [IDALink to PubMed articleLink to PubMed article]
    soluble fraction [IDALink to PubMed article]
    cytosol [IDALink to PubMed articleLink to PubMed article]
    intracellular [IEALink to PubMed article]
    Biological Process: regulation of caspase activity [IDALink to PubMed article][IMPLink to PubMed article]
    positive regulation of apoptosis [IDALink to PubMed article][IMPLink to PubMed article]
    apoptosis [IEALink to PubMed article]
    regulation of apoptosis [IEALink to PubMed article]
    Molecular Function: nucleotide binding [IEALink to PubMed article]
    BH3 domain binding [IPILink to PubMed article]
    ATP binding [IEALink to PubMed article]
    protein binding [IEALink to PubMed article][IPILink to PubMed articleLink to PubMed article]
    BH1 domain binding [IPILink to PubMed article]
    nucleoside-triphosphatase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLCEIECRAL STAHTRLIHD FEPRDALTYL EGKNIFTEDH SELISKMSTR LERIANFLRI  60
   61 YRRQASELGP LIDFFNYNNQ SHLADFLEDY IDFAINEPDL LRPVVIAPQF SRQMLDRKLL 120
  121 LGNVPKQMTC YIREYHVDRV IKKLDEMCDL DSFFLFLHGR AGSGKSVIAS QALSKSDQLI 180
  181 GINYDSIVWL KDSGTAPKST FDLFTDILLM LKSEDDLLNF PSVEHVTSVV LKRMICNALI 240
  241 DRPNTLFVFD DVVQEETIRW AQELRLRCLV TTRDVEISNA ASQTCEFIEV TSLEIDECYD 300
  301 FLEAYGMPMP VGEKEEDVLN KTIELSSGNP ATLMMFFKSC EPKTFEKMAQ LNNKLESRGL 360
  361 VGVECITPYS YKSLAMALQR CVEVLSDEDR SALAFAVVMP PGVDIPVKLW SCVIPVDICS 420
  421 NEEEQLDDEV ADRLKRLSKR GALLSGKRMP VLTFKIDHII HMFLKHVVDA QTIANGISIL 480
  481 EQRLLEIGNN NVSVPERHIP SHFQKFRRSS ASEMYPKTTE ETVIRPEDFP KFMQLHQKFY 540
  541 DSLKNFACC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..549] PSI-BLAST 55.0 Structure of a CED-4/CED-9 complex


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle