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Protein Overview: unc-86

General Information:
Name(s) found: unc-86 / CE00099 [WormBase]
Description(s) found:
Found 23 descriptions.
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  • WBGene00006818 locus:unc-86 Pou homeodomain status:Partially_confirmed UniProt:P13528 protein_id:AAB59176.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 467 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: mechanosensory behavior [IMPLink to PubMed articleLink to PubMed article]
    locomotory behavior [IMPLink to PubMed article]
    regulation of transcription, DNA-dependent [IEALink to PubMed article]
    oviposition [IMPLink to PubMed articleLink to PubMed article]
    neuron development [IMPLink to PubMed articleLink to PubMed article]
    response to mechanical stimulus [IMPLink to PubMed articleLink to PubMed article]
    positive regulation of locomotion [IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IEALink to PubMed article]
    sequence-specific DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKAHRFRLP FCSFFPVPLL VSVLIFHHSA PFLIQLFFPS PLFNPLLRPS KISRGSENGA  60
   61 CTSHSTLQRT RKIIQWELPK RGGDQDIGDP RPFRIHLSPP SFKVPLFSTD MQNTAPVPTT 120
  121 TTASKMQPFN NSLFGSFDDP ILNARAAQVA LADIDVKNVP QLTNPLMRPH DMFSYSNYFS 180
  181 GIHDTSAATN IYQGLPSSSE PFDASVVVPT SSDDQMTPLQ QVMAMQQSYG APPPFQYNMT 240
  241 HPFSTTSIAS SNNLARYPIA PPTSDMDTDP RQLETFAEHF KQRRIKLGVT QADVGKALAH 300
  301 LKMPGVGSLS QSTICRFESL TLSHNNMVAL KPILHSWLEK AEEAMKQKDT IGDINGILPN 360
  361 TDKKRKRTSI AAPEKRELEQ FFKQQPRPSG ERIASIADRL DLKKNVVRVW FCNQRQKQKR 420
  421 DFRSQFRARS AAAVMGPRVM PVLNGNNSNN NLKQGQTTYN GLPGFFD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158] MSA 7.290996 View MSA. No confident structure predictions are available.
    2 View Details [159..245] MSA 2.484997 View MSA. No confident structure predictions are available.
    3 View Details [246..467] PSI-BLAST 23.221849 TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • DNA binding
    		•  5.51228466689923 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.37468811865033 bayes_pls_golite062009
  • transcription regulator activity
    		•  5.05236457497789 bayes_pls_golite062009
  • transcription factor activity
    		•  3.89464979825638 bayes_pls_golite062009
  • binding
    		•  3.66501723413351 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.25218945600666 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.22754992035091 bayes_pls_golite062009
  • transcription activator activity
    		•  3.15886611325686 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.75958281319075 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.62096064323298 bayes_pls_golite062009
  • protein binding
    		•  1.55649304400241 bayes_pls_golite062009
  • chromatin binding
    		•  1.2739759748489 bayes_pls_golite062009
  • transcription factor binding
    		•  1.02788976342343 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.92393807212912 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.8718993114781 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.81316180547536 bayes_pls_golite062009
  • promoter binding
    		•  0.22765608166458 bayes_pls_golite062009
  • catalytic activity
    		•  0.00446472034106909 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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