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View Structure Prediction Details

Protein: unc-86
Organism: Caenorhabditis elegans
Length: 467 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for unc-86.

Description E-value Query
Range
Subject
Range
unc-86 - Pou homeodomain status:Partially_confirmed UniProt:P13528 protein_id:AAB59175.1
191.0 [0..1] [467..1]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKAHRFRLP FCSFFPVPLL VSVLIFHHSA PFLIQLFFPS PLFNPLLRPS KISRGSENGA  60
   61 CTSHSTLQRT RKIIQWELPK RGGDQDIGDP RPFRIHLSPP SFKVPLFSTD MQNTAPVPTT 120
  121 TTASKMQPFN NSLFGSFDDP ILNARAAQVA LADIDVKN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [159-245]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VPQLTNPLMR PHDMFSYSNY FSGIHDTSAA TNIYQGLPSS SEPFDASVVV PTSSDDQMTP  60
   61 LQQVMAMQQS YGAPPPFQYN MTHPFST

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [246-467]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSIASSNNLA RYPIAPPTSD MDTDPRQLET FAEHFKQRRI KLGVTQADVG KALAHLKMPG  60
   61 VGSLSQSTIC RFESLTLSHN NMVALKPILH SWLEKAEEAM KQKDTIGDIN GILPNTDKKR 120
  121 KRTSIAAPEK RELEQFFKQQ PRPSGERIAS IADRLDLKKN VVRVWFCNQR QKQKRDFRSQ 180
  181 FRARSAAAVM GPRVMPVLNG NNSNNNLKQG QTTYNGLPGF FD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.221849
Match: 1o4xA
Description: TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 5.51228466689923 bayes_pls_golite062009
nucleic acid binding 5.37468811865033 bayes_pls_golite062009
transcription regulator activity 5.05236457497789 bayes_pls_golite062009
transcription factor activity 3.89464979825638 bayes_pls_golite062009
binding 3.66501723413351 bayes_pls_golite062009
sequence-specific DNA binding 3.25218945600666 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.22754992035091 bayes_pls_golite062009
transcription activator activity 3.15886611325686 bayes_pls_golite062009
transcription repressor activity 1.75958281319075 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
protein binding 1.55649304400241 bayes_pls_golite062009
chromatin binding 1.2739759748489 bayes_pls_golite062009
transcription factor binding 1.02788976342343 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.92393807212912 bayes_pls_golite062009
transcription cofactor activity 0.8718993114781 bayes_pls_golite062009
transcription coactivator activity 0.81316180547536 bayes_pls_golite062009
promoter binding 0.22765608166458 bayes_pls_golite062009
catalytic activity 0.00446472034106909 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle