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Protein Overview: hri1

General Information:
Name(s) found: hri1 / SPAC20G4.03c [Sanger Pombe]
Description(s) found:
Found 22 descriptions.
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  • eIF2 alpha kinase Hri1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 704 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: negative regulation of translational initiation in response to osmotic stress [IGILink to PubMed article]
    cellular response to stress [IMPLink to PubMed article]
    protein amino acid phosphorylation [IDALink to PubMed article]
    Molecular Function: ATP binding [ISSLink to PubMed article]
    protein binding [IGILink to PubMed article]
    eukaryotic translation initiation factor 2alpha kinase activity [NASLink to PubMed article]
    protein serine/threonine kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLGTSTKCSK RDCNYAKENI SRIMPTIGLG YKQNFEKKTA DTQSSCKLLL VALLESFCKH  60
   61 SDQTPEQSKQ MFLYVAHSLQ NSGIIDFEFS EELEPIRNAY ADSLHNLLSK AFRSTLPMSS 120
  121 TKDSKKSRYS SPDGVLAKTA SFLSVLSDGG YEDDVMNVKP SVNVLSNRLN HLPVEALESC 180
  181 FPQTTLESST FADFCEHKDG TGNLSFSNFD SFPTVQRSRY ASDFEELELL GKGGYGSVYK 240
  241 ARNKFDGVEY ALKKIPLRLR SFSTSSNIFR ESRTLARLNH PNVIRFFSSW VELLPSSEKQ 300
  301 IEEEPLASAD ETLSQSADID NFMFDMDTGL LQHTYPSSVQ ILFQEDSVAD DLTPCYSTKN 360
  361 STCNLTDLFK KEADQDYAES HDCSSTTSQV DTLGKLAPTK SASEMLLMDS FLSEREEDEC 420
  421 SNIPSFDQQP LCLYIQMALC EETLEKHINR RNKHIHGVMS KGLRNCYILL FARILEGVLY 480
  481 LHDAMHLVHR DLKPRNIFLS SGVHSEPCSV CLPNFSDEDN VEVSNAYEPV NQRTLCVVPK 540
  541 IGDFGLVLSQ SDNLEEGTNS SAESSFVGTS TYAAPELFSK HMRSVMNNNS STDIYALGIL 600
  601 FFELLYPFNT RMERASAIAN LKKGIFPHDF LDSMPEEASL IRSMLSSSNK RPTAAQLLTS 660
  661 NLFHDLVVNE LHVYQALLED AEKRNNNLKA ELNILRVLNP NYDC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..165] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [166..397] FFAS03 4.74 Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K
    3 View Details [398..704] PSI-BLAST 39.221849 Crystal Structure of eIF2alpha Protein Kinase GCN2: R794G Hyperactivating Mutant in Apo Form.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.1266532460433 bayes_pls_golite062009
  • kinase activity
    		•  4.97217471277362 bayes_pls_golite062009
  • protein kinase activity
    		•  4.77883995812872 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.63130611618105 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.09005206351126 bayes_pls_golite062009
  • transferase activity
    		•  3.71864228364346 bayes_pls_golite062009
  • binding
    		•  2.03461352348797 bayes_pls_golite062009
  • ATP binding
    		•  1.74734232320398 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.71077512212789 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.68781845572802 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.45955619008784 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.45954404692843 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.44332631201954 bayes_pls_golite062009
  • nucleotide binding
    		•  1.43931752337662 bayes_pls_golite062009
  • protein binding
    		•  1.15120816013834 bayes_pls_golite062009
  • catalytic activity
    		•  1.13659909751975 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.07654572354135 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.06242930071592 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.989242693203213 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.381500617389712 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.267060103197739 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.206707239579918 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.185239852962563 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.134608114107045 bayes_pls_golite062009
  • DNA binding
    		•  0.129610572349837 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.073383252842333 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.0583007878333612 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0348535280588368 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle