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View Structure Prediction Details

Protein: hri1
Organism: Schizosaccharomyces pombe
Length: 704 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hri1.

Description E-value Query
Range		 Subject
Range
gi|115931831, gi... - gi|115931831|ref|XP_001180946.1| PREDICTED: similar to serine/threonine-protein kinase 38 (ndr2 prot...
 277.0 [0..193] [691..52]
gi|24899168 - gi|24899168|dbj|BAC23098.1| phototropin [Vicia faba]
 254.0 [0..1] [693..257]
gi|6006312 - gi|6006312|dbj|BAA84780.1| nonphototrophic hypocotyl 1a [Oryza sativa Japonica Group]
 253.0 [0..2] [692..233]
gi|2687358, gi|1... - pir||T01353 serine/threonine protein kinase (EC 2.7.1.-), nonphototropic hypocotyl protein 1-like [s...
 252.0 [0..2] [703..224]
gi|6688928 - gi|6688928|emb|CAB65325.1| non-phototropic hypocotyl NPH1 [Oryza sativa (indica cultivar-group)]
 251.0 [0..2] [692..233]
gi|60099454 - gi|60099454|dbj|BAD89966.1| phototropin [Phaseolus vulgaris]
 250.0 [0..2] [699..275]
gi|7489361, gi|2... - pir||T08033 serine/threonine protein kinase (EC 2.7.1.-) 1, nonphototropic hypocotyl protein 1-like ...
 249.0 [0..2] [687..233]

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Predicted Domain #1
Region A:
Residues: [1-165] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLGTSTKCSK RDCNYAKENI SRIMPTIGLG YKQNFEKKTA DTQSSCKLLL VALLESFCKH  60
   61 SDQTPEQSKQ MFLYVAHSLQ NSGIIDFEFS EELEPIRNAY ADSLHNLLSK AFRSTLPMSS 120
  121 TKDSKKSRYS SPDGVLAKTA SFLSVLSDGG YEDDVMNVKP SVNVL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.847 0.531 eukaryotic translation initiation factor 2alpha kinase activity a.45.1 Glutathione S-transferase (GST), C-terminal domain

Predicted Domain #2
Region A:
Residues: [166-397] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNRLNHLPVE ALESCFPQTT LESSTFADFC EHKDGTGNLS FSNFDSFPTV QRSRYASDFE  60
   61 ELELLGKGGY GSVYKARNKF DGVEYALKKI PLRLRSFSTS SNIFRESRTL ARLNHPNVIR 120
  121 FFSSWVELLP SSEKQIEEEP LASADETLSQ SADIDNFMFD MDTGLLQHTY PSSVQILFQE 180
  181 DSVADDLTPC YSTKNSTCNL TDLFKKEADQ DYAESHDCSS TTSQVDTLGK LA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 4.74
Match: 1u5qA
Description: Crystal Structure of the TAO2 Kinase Domain: Activation and Specifity of a Ste20p MAP3K
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphotransferase activity, alcohol group as acceptor 5.1266532460433 bayes_pls_golite062009
kinase activity 4.97217471277362 bayes_pls_golite062009
protein kinase activity 4.77883995812872 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.63130611618105 bayes_pls_golite062009
protein serine/threonine kinase activity 4.09005206351126 bayes_pls_golite062009
transferase activity 3.71864228364346 bayes_pls_golite062009
binding 2.03461352348797 bayes_pls_golite062009
ATP binding 1.74734232320398 bayes_pls_golite062009
adenyl ribonucleotide binding 1.71077512212789 bayes_pls_golite062009
adenyl nucleotide binding 1.68781845572802 bayes_pls_golite062009
purine ribonucleotide binding 1.45955619008784 bayes_pls_golite062009
ribonucleotide binding 1.45954404692843 bayes_pls_golite062009
purine nucleotide binding 1.44332631201954 bayes_pls_golite062009
nucleotide binding 1.43931752337662 bayes_pls_golite062009
protein binding 1.15120816013834 bayes_pls_golite062009
catalytic activity 1.13659909751975 bayes_pls_golite062009
protein tyrosine kinase activity 1.07654572354135 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.06242930071592 bayes_pls_golite062009
receptor signaling protein activity 0.989242693203213 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.381500617389712 bayes_pls_golite062009
nucleic acid binding 0.267060103197739 bayes_pls_golite062009
transcription regulator activity 0.206707239579918 bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity 0.185239852962563 bayes_pls_golite062009
magnesium ion binding 0.134608114107045 bayes_pls_golite062009
DNA binding 0.129610572349837 bayes_pls_golite062009
MAP kinase kinase kinase activity 0.073383252842333 bayes_pls_golite062009
MAP kinase kinase activity 0.0583007878333612 bayes_pls_golite062009
transcription repressor activity 0.0348535280588368 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [398-704] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PTKSASEMLL MDSFLSEREE DECSNIPSFD QQPLCLYIQM ALCEETLEKH INRRNKHIHG  60
   61 VMSKGLRNCY ILLFARILEG VLYLHDAMHL VHRDLKPRNI FLSSGVHSEP CSVCLPNFSD 120
  121 EDNVEVSNAY EPVNQRTLCV VPKIGDFGLV LSQSDNLEEG TNSSAESSFV GTSTYAAPEL 180
  181 FSKHMRSVMN NNSSTDIYAL GILFFELLYP FNTRMERASA IANLKKGIFP HDFLDSMPEE 240
  241 ASLIRSMLSS SNKRPTAAQL LTSNLFHDLV VNELHVYQAL LEDAEKRNNN LKAELNILRV 300
  301 LNPNYDC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.221849
Match: 1zy4A
Description: Crystal Structure of eIF2alpha Protein Kinase GCN2: R794G Hyperactivating Mutant in Apo Form.
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle