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Protein Overview: SPBC1734.03

General Information:
Name(s) found: SPBC1734.03 [Sanger Pombe]
Description(s) found:
Found 17 descriptions.
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  • dihydropteroatesynthase/2-amino-4-hydroxy-6-hydroxymethyldihydropteridinediphosphokinase/dihydroneopterinaldolase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 686 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article][ISSLink to PubMed article]
    mitochondrion [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: folic acid and derivative biosynthetic process [ISSLink to PubMed article]
    folic acid biosynthetic process [IEA]
    tetrahydrofolate biosynthetic process [IEA]
    Molecular Function: ATP binding [IEA]
    dihydroneopterin aldolase activity [ISSLink to PubMed article]
    2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity [ISSLink to PubMed article]
    dihydropteroate synthase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLIHDTVVV ENLNTFAVVG QDQWKRKEPQ PVQIDVYMRN NVQLAGEKDE LKSTIHYGIA  60
   61 SKLLRKEIEG SFFTTPKDLV NKIASLCFED VIDTSHVSIK LTLPKCVLRS KNGLHYYAER 120
  121 ERNSTSNFVD RIEFSDLELA TILGIHAFER QEKQRVCLNI SFANTEVEAL EIARAIAEYV 180
  181 EQSAFLTIEA LVVNLSKYLC FTKNLDDISI KAEKPSAITF ANASAVQIYR TRSYFLQESL 240
  241 HKYESTKNKI AYLSFGSNIG DKFEQIQTAL SMLHKIEGIR VLDVSPLYET EPMYYKDQPS 300
  301 FLNGVCKIET RMSPINLLRA CQSIEQEMGR IKTILKGPRC IDLDIVLYED CVYESEVLTI 360
  361 PHLGLQEREF VLRPLLALSP DLVHPYTHQP LQEALDKLPS QGIRLYSSFD NKKIINGALT 420
  421 MGILNVTPDS FSDGGKVSQN NILEKAKSMV GDGASILDIG GQSTKPGADP VSVEEELRRV 480
  481 IPMISLLRSS GITVPISIDT YYSKVAKLAI EAGANIINDV TGGMGDEKML PLAASLQVPI 540
  541 CIMHMRGTPE TMKALSIYEK DIVEEVAVEL SSRVEAAVQS GVHRYNIILD PGFGFAKTPK 600
  601 QSAGLLGRLH ELMKKPQFKD MHWLSGPSRK GFTGYFTGDA SPKDRIWGTS ACVTASVLQG 660
  661 VSIVRVHDTK EMSKVVGMAN AIRYVP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..124] PSI-BLAST 32.154902 1.65 ANGSTROM RESOLUTION STRUCTURE OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS
    2 View Details [125..244] PSI-BLAST 56.0 No description for 2cg8A was found.
    3 View Details [245..686] PSI-BLAST 98.39794 X-ray structure of the bifunctional 6-hydroxymethyl-7,8- dihydroxypterin pyrophosphokinase dihydropteroate synthase from Sacchromyces cerevisiae

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • GTP cyclohydrolase I activity
    		•  4.1430878480831 bayes_pls_golite062009
  • cyclohydrolase activity
    		•  3.66553359909123 bayes_pls_golite062009
  • GTP cyclohydrolase activity
    		•  3.44912994722205 bayes_pls_golite062009
  • 6-pyruvoyltetrahydropterin synthase activity
    		•  2.77658228107642 bayes_pls_golite062009
  • dihydroneopterin aldolase activity
    		•  2.51107306055654 bayes_pls_golite062009
  • catalytic activity
    		•  2.20788162511962 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  1.73101699306211 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.974891318710762 bayes_pls_golite062009
  • binding
    		•  0.641976427105342 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.0783540825826956 bayes_pls_golite062009
  • protein binding
    		•  0.045916344848404 bayes_pls_golite062009
  • urate oxidase activity
    		•  0.0294957696532921 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle