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Protein Overview: ptn1

General Information:
Name(s) found: ptn1 / SPBC609.02 [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • phosphatidylinositol-3,4,5-trisphosphate3-phosphatase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 348 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    cytoplasmic membrane-bounded vesicle [IEA]
    Biological Process: cellular water homeostasis [IMPLink to PubMed article]
    vacuole organization [IMPLink to PubMed article]
    signal transduction [IC]
    protein amino acid dephosphorylation [IEA]
    phosphatidylinositol metabolic process [IMPLink to PubMed article]
    Molecular Function: phosphoprotein phosphatase activity [IEA]
    phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity [IDALink to PubMed article]
    protein tyrosine/serine/threonine phosphatase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNILRSVVSR GRKGLKQEKV NRSFAYLDMV YITSKVIAMS TPAAGIHKLY RNDELDVFKY  60
   61 LTTQLKDNWI LLNLCAEETV YHLELFKPNV INYGFQDHNP PPLLFLWAIV MNMDALFQTQ 120
  121 PLLTLVVHCK AGKGRTGTVI CSYLVAFGGL TAKQSLELYT EKRMVRGHGL TISSQIRYVY 180
  181 YIEILKQFPN YLKAVEFNTG TTFFKSFKCL NIKKNSSLIL SLHAFSKGRN INPVALWKSS 240
  241 DISSHNVSIK EGKRIWGIQC NLETSEKDLL LRVERKGQFY FPSSVQCWFH THFQPMLVEY 300
  301 TNGINFQQGI NSFLQGQQSI SFSWSEMDNS RRSDPFFEQL TIVYENVF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..348] PSI-BLAST 63.30103 Pten tumor suppressor (Phoshphoinositide phosphatase), C-terminal domain; Phoshphoinositide phosphatase Pten (Pten tumor suppressor), N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphatase activity
    		•  4.32491463105526 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  3.62225401667721 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  2.77444127020865 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  2.31420088972663 bayes_pls_golite062009
  • phosphatidylinositol trisphosphate phosphatase activity
    		•  2.05577133553311 bayes_pls_golite062009
  • phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
    		•  1.72084618199574 bayes_pls_golite062009
  • binding
    		•  1.63082376187819 bayes_pls_golite062009
  • phosphatidylinositol-3-phosphatase activity
    		•  1.34604477322161 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.26980045117425 bayes_pls_golite062009
  • phosphoprotein phosphatase activity
    		•  1.1478558008509 bayes_pls_golite062009
  • protein binding
    		•  1.07441758584517 bayes_pls_golite062009
  • catalytic activity
    		•  1.06283028154109 bayes_pls_golite062009
  • phospholipase activity
    		•  0.689713182053935 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  0.631959343178681 bayes_pls_golite062009
  • calcium-dependent phospholipid binding
    		•  0.368277796845269 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.291525352733402 bayes_pls_golite062009
  • receptor activity
    		•  0.191946218805025 bayes_pls_golite062009
  • phospholipase C activity
    		•  0.105085008317406 bayes_pls_golite062009
  • phosphatidylinositol bisphosphate phosphatase activity
    		•  0.0736057996833881 bayes_pls_golite062009
  • hydrolase activity
    		•  0.018205178993884 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle