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Protein Overview: SPAC19G12.09

General Information:
Name(s) found: SPAC19G12.09 [Sanger Pombe]
Description(s) found:
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  • pir||T37996 probable aldose reductase - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|74626610|sp|O13848.1|I3ACR_SCHPO RecName: Full=NAD/NADP-dependent indole-3-acetaldehyde reductase; AltName: Full=AKR3C2 [NCBI NR]
  • gi|2239203|emb|CAB10120.1| NADH/NADPH dependent indole-3-acetaldehyde reductase AKR3C2 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19115336|ref|NP_594424.1| NADH/NADPH dependent indole-3-acetaldehyde reductase AKR3C2 [Schizosaccharomyces pombe] [NCBI NR]
  • NADH/NADPH dependent indole-3-acetaldehyde reductase AKR3C2 [Sanger Pombe]
  • NAD/NADP-dependent indole-3-acetaldehyde reductase OS=Schizosaccharomyces pombe GN=SPAC19G12.09 PE=1 SV=1 [Swiss-Prot]
  • PUTATIVE ALDOSE REDUCTASE: O13848; [pompepVF.fasta]
  • Putative aldose reductase [pompep4896]
  • |||putative oxidoreductase [pompepnew.fasta]
  • SPAC19G12.09 protein [4896.FASTAC]
  • |||oxidoreductase (predicted)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • putative aldose reductase [Schizosaccharomyces pombe]gi|2239203|emb|CAB10120.1| SPAC19G12.09 [Schizosaccharomyces pombe]gi|7492371|pir||T37996 probable aldose reductase - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas]
  • |||NADPH-dependent alpha-keto amide reductase |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (O13848) Putative aldose reductase [pompep4896_normal_reversed]
  • |||NADH/NADPH dependent indole-3-acetaldehyde reductase AKR3C2|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC19G12.09 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC19G12.09 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • NAD/NADP-dependent indole-3-acetaldehyde reductase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC19G12.09 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 284 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    cytoplasm [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: cellular response to stress [IEPLink to PubMed article]
    Molecular Function: alpha-keto amide reductase activity [ISSLink to PubMed article]
    alpha-keto ester reductase activity [ISSLink to PubMed article]
    indole-3-acetaldehyde reductase (NADPH) activity [IDALink to PubMed article]
    indole-3-acetaldehyde reductase (NADH) activity [IDALink to PubMed article]
    oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLIAAMGPKI PVPAYGVGTA LFKKEKGEIN RTIVDSVKNA LAAGFIHIDC AEVYGNEEEV  60
   61 GVALKEANVP RSKLFITSKV MHNVDNIPEA LNESLRKLGT DYLDLYLLHS PIPFYEKKIP 120
  121 ISEGWKAMET ALGTGLVHSV GVSNFRIPDL EELLKTSTIT PRVNQIEFHP QVYKAAKPLV 180
  181 EFCQSKGIIV EGYGPLSPLV RDAQGPVAEF TKSLESKYHV SDTQILLKWA YSKGVIPITT 240
  241 TSKIERMKEC LNFDSFTLDK ADIDELGTLG VQHHKRTFMK HMDE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run dam1 No Comments Liu X, et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..284] PSI-BLAST 72.522879 ALDEHYDE REDUCTASE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • aldehyde reductase activity
    		•  5.07106269693426 bayes_pls_golite062009
  • L-glucuronate reductase activity
    		•  4.06568552614053 bayes_pls_golite062009
  • arabinose reductase activity
    		•  3.28910924444005 bayes_pls_golite062009
  • xylose reductase activity
    		•  3.28910924444005 bayes_pls_golite062009
  • glucose 1-dehydrogenase (NADP+) activity
    		•  2.68048267823456 bayes_pls_golite062009
  • aldo-keto reductase activity
    		•  2.57303336304449 bayes_pls_golite062009
  • trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
    		•  2.43245618396666 bayes_pls_golite062009
  • 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity
    		•  2.43245618396666 bayes_pls_golite062009
  • alpha-keto ester reductase activity
    		•  2.31616201247794 bayes_pls_golite062009
  • alpha-keto amide reductase activity
    		•  2.31616201247794 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  2.19555484888528 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.87468990921314 bayes_pls_golite062009
  • catalytic activity
    		•  1.68179794468736 bayes_pls_golite062009
  • glucose 1-dehydrogenase activity
    		•  1.55697325009049 bayes_pls_golite062009
  • bile acid transmembrane transporter activity
    		•  1.47447940903315 bayes_pls_golite062009
  • monocarboxylic acid transmembrane transporter activity
    		•  1.45034485133104 bayes_pls_golite062009
  • binding
    		•  1.3044513338497 bayes_pls_golite062009
  • bile acid binding
    		•  1.28757511368757 bayes_pls_golite062009
  • transporter activity
    		•  1.24767072239634 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.22645031212774 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  1.20678148401125 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  1.19919645230426 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-CH group of donors
    		•  1.15597377782029 bayes_pls_golite062009
  • 3-oxo-5-beta-steroid 4-dehydrogenase activity
    		•  1.15597377782029 bayes_pls_golite062009
  • protein binding
    		•  1.06359558718341 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.03420335553507 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  0.868027162240181 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.86591084281532 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.783004917746429 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.544360068128604 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.260605752589411 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0547047948210824 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle