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Protein Overview: rpn2

General Information:
Name(s) found: rpn2 / SPBC17D11.07c [Sanger Pombe]
Description(s) found:
Found 17 descriptions.
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  • 19S proteasome regulatory subunit Rpn2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 965 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][TASLink to PubMed article]
    proteasome regulatory particle, base subcomplex [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: proteasomal ubiquitin-dependent protein catabolic process [NASLink to PubMed article]
    regulation of catalytic activity [IC]
    regulation of protein catabolic process [IEA]
    regulation of cell cycle [RCALink to PubMed article]
    mitotic cell cycle [IC]
    ubiquitin-dependent protein catabolic process [ISSLink to PubMed article]
    Molecular Function: endopeptidase activity [ISSLink to PubMed article]
    enzyme regulator activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTMVYSDNTS IITSAGGLMA LLDEQERELQ VHALLKIYEF IDQLWPEISD DVTKIEVMYE  60
   61 DHSFPERELA ALVVSKVYYY LGEYDEALLF ALSSGPKFLH DKNSDYKETL IFKCIDMFIH 120
  121 KSAELYKNPK ADPLDERLSG VVEGIFQKCY AKNEWRHVLG IAIEAHRLDI IEYILNADKE 180
  181 TDLKPYVLEL AMTVVLDIEF RNRLLRLLLS SFLTETEPDY FSVGKCVVHL NDASVAAKLL 240
  241 MKLSSQNDDK SLLTAYQLAF DLEDSAPQEF LNSVMDLLPS PSVANSEEDA NADSKKEDSS 300
  301 PCGYIIRILS GEQTVKYDRE FLYAHNNTDM LILNRTKDSL EARNSVFHNA VTFANAFMNF 360
  361 GTSSDSFFRD NLSWLSKANN WSKFTATAAL GVIHRGYYNQ AMNILRPYLP EEDAPSSSTY 420
  421 SEGGAFYAMG LIHANHGRGV TEYLREQLKH TEDEIVQYGL LLGIGLTGMA SRDETLYESV 480
  481 KTILFNDNAV AGSAAGISMG LIMLGTASSA AIDEMLQYAH ETQHEKIIRG LGIGIALIVY 540
  541 GRQQEADGII KELNNDLDPT LRYAGMFATA LAYCGTSNSK IVRDVLHISV SDVNDDVRRA 600
  601 AVCALGFICF KDPNALISTV ELLVDSYNPH VRYGSAIALG IACANSGSNA ALDLLSRLVE 660
  661 DATDFVRQGA MIAQAMILTQ HNDQLNSKVS GIRKHFEQVI NEKHEDALAK LGATLAQGII 720
  721 DAGGRNVTIA LQTATGSLKL SAIVGLTVFL QYWYWFPLTH FMSLSFSPTA LIGLDKNLNA 780
  781 PKFSFISNVR PKLFAYPPKS VQPTAKTVQK VETAVLSTTV KAQARAKRAE REKASKGSND 840
  841 DEMKIDKKTT EEKEATPMEM DEEKSQDISI NGNSKKEEPK SETLENFTRV VPAQLPYISF 900
  901 NLNGRYYPVR KFTGGVLMLI DRESDKAPDL IELNRDAVPA SADTEPGEQE ASPPEDFEYP 960
  961 FDDDD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..722] PSI-BLAST 61.522879 Karyopherin beta2
    2 View Details [723..855] PSI-BLAST 15.154902 Kap95p:RanGTP complex
    3 View Details [856..965] MSA 10.185997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.86831493830281 bayes_pls_golite062009
  • hydrolase activity
    		•  2.5894939457048 bayes_pls_golite062009
  • protein binding
    		•  1.63705839411934 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.23804310697631 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.13208464017585 bayes_pls_golite062009
  • structural molecule activity
    		•  0.440301695287117 bayes_pls_golite062009
  • actin binding
    		•  0.360199499297314 bayes_pls_golite062009
  • DNA binding
    		•  0.171056781378569 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.123389318446902 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.41

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle