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Protein Overview: rgf2

General Information:
Name(s) found: rgf2 / SPAC1006.06 [Sanger Pombe]
Description(s) found:
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  • gi|90109812|sp|Q9UTR5.1|RGF2_SCHPO RecName: Full=Rho1 guanine nucleotide exchange factor 2 [NCBI NR]
  • gi|6318256|emb|CAB60236.1| RhoGEF Rgf2 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19115765|ref|NP_594853.1| RhoGEF Rgf2 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|11288449|pir||T50454 probable rho1 GDP-GTP exchange protein [imported] - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • RhoGEF Rgf2 [Sanger Pombe]
  • Rho1 guanine nucleotide exchange factor 2 OS=Schizosaccharomyces pombe GN=rgf2 PE=1 SV=1 [Swiss-Prot]
  • PUTATIVE RHO1 GDP-GTP EXCHANGE PROTEIN: Q9UTR5; [pompepVF.fasta]
  • Putative rho1 GDP-GTP exchange protein [pompep4896]
  • |reserved_name_rgf2||putative rho1 GDP-GTP exchange protein [pompepnew.fasta]
  • Reserved_name_rgf2 protein (Spac1006.06 protein) [4896.FASTAC]
  • |rgf2||GDP-GTP exchange protein for Rho1p (predicted)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • putative rho1 GDP-GTP exchange protein [Schizosaccharomyces pombe]gi|6318256|emb|CAB60236.1| SPAC1006.06 [Schizosaccharomyces pombe]gi|11288449|pir||T50454 probable rho1 GDP-GTP exchange protein [imported] - fission yeast (Schizosaccharomyces pombe) [nrdb_11152004_Chlamydomonas]
  • |rgf2||GDP-GTP exchange protein for Rho1p |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q9UTR5) Putative rho1 GDP-GTP exchange protein [pompep4896_normal_reversed]
  • |rgf2||RhoGEF Rgf2|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC1006.06 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC1006.06 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Rho1 guanine nucleotide exchange factor 2 [nr-271106-contam.fasta]
  • Rho1 guanine nucleotide exchange factor 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rgf2 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 1158 amino acids

    Gene Ontology:
    Cellular Component: barrier septum [IDALink to PubMed article]
    cell cortex of cell tip [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: fungal-type cell wall biogenesis [IGILink to PubMed article][IMPLink to PubMed article]
    selection of site for barrier septum formation [IMPLink to PubMed article]
    regulation of Rho protein signal transduction [IEA]
    regulation of small GTPase mediated signal transduction [IGILink to PubMed article]
    regulation of catalytic activity [ICLink to PubMed article]
    actin cortical patch localization [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    Rho guanyl-nucleotide exchange factor activity [IGILink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRNGAQNGN INSESHESFG KAAKGFRIFS SFSSSQKLFQ RRSSGSITHS PTALSSTTSL  60
   61 NENDGNHFRP ASSLSFSPSS LSRKDSGPGD GLEVNKKNNF YRRSSSTDDF GISHARSRKE 120
  121 IQSLGRPHTR QSFSVSDVSN GSSYPNIRKN SVHVNAPMPS FPEGSTAVLL KHHSGSKSAS 180
  181 AISNIAPSHS NSTSSRRPYI HPAFLSQVAV EFRKRLNIGD RVKDGLLYKD AFLGSEAVDV 240
  241 LMHIVRTTDR NLALLLGRAL DSQKMFHDVT YSHRLRDSLK EVYQYRRIIS PPPGLSSMDS 300
  301 NGSSIENNFL YTKRRANTSD SFDSVLSDSS TTPTISSSVQ VNSLAFITSS LSAITKEPEA 360
  361 PETEYNPHGV FTLLTECYSS TCSRNRLCYS ISCPRRLEQQ ARLHLKVQPV LSGGSTSITD 420
  421 KQEEDHRLWS ENVPKQVVDQ IDVREWKRQE IIFEVIYTER DFVRDLEYIR DFWIKPLSTS 480
  481 NVIPENNRQQ FIRCVFHNIM QIHAVNSRLS NALNRTQTLQ PVVNTIGDLF LDYVPKFEPF 540
  541 IKYGANQAIA KFEFEREKST NRNFANYVHE VERLRESRKL ELNGYLTKPT TRLARYPLLL 600
  601 SGVLKYTDKD NPDTENIPRV IEMIREFLTK LNYETGKTEN RLSLLQLNEQ LSCSPADRAK 660
  661 LTLFDPSRLL IFKGVVKLKA SSYSNGDTEN DIHMFLLDNF LLLCKIKIQM KRRVHKLHLR 720
  721 PLPLELLSIS YIEDSPSRGS LPRRPSSALL TNPISITKSN PPPVKAYGLQ LVFIGARGFS 780
  781 ISLYLNTLIA RDQWKQHIEK QQDIIRKRHL VFESRGICCQ SWFTGNKLLC AVAYDAGRKL 840
  841 LFGTYKGLYI SSRKSNNGSC LEPIFKLQLP NISQLDVIEE HNVLLLLAEK ILYELPLDAL 900
  901 DSVEQINSKS LRRVTGHVSF VKTGFCMQRI LVCAVKSTVL NTTLRIYEAD RALKNKKTQS 960
  961 LKKPFGNQAT LKIFTEVQMP MEALSVHFLK TKLCVGSFKG FDIISLENAV FQSLLNPADT1020
 1021 SFRFLEKRED IRPIAMFRLR GEFLLCYSDF AFFVNTNGWK SRQSWMINWE GQPQGCALCY1080
 1081 PYILAFEPDF IEIRNAETAE LVQIIMGQNI KLLTDGRGLI SEGGEILYST EPIPFSSGEN1140
 1141 PIVHSLILPP ANAAGPAL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..183] MSA 11.430996 View MSA. No confident structure predictions are available.
    2 View Details [184..296] FFAS03 1.94 Segment polarity protein Dishevelled-1
    3 View Details [297..821] PSI-BLAST 77.30103 No description for 2pz1A was found.
    4 View Details [822..881] PSI-BLAST 45.221849 Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang.
    5 View Details [882..997] deduced N/A No confident structure predictions are available.
    6 View Details [998..1158] MSA 2.077968 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.73671056234733 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.41707457507137 bayes_pls_golite062009
  • DNA binding
    		•  2.18117896363198 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11083019950216 bayes_pls_golite062009
  • transcription factor activity
    		•  1.56137531585812 bayes_pls_golite062009
  • protein binding
    		•  0.726445167461826 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.303801645888354 bayes_pls_golite062009
  • transcription activator activity
    		•  0.136681432225981 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0427811016336385 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle